2. Signaling Pathways
  3. Anti-infection
  4. HSV

HSV

Herpes simplex virus

HSV

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HSV (Herpes simplex virus) can be spread when an infected person is producing and shedding the virus. Herpes simplex can be spread through contact with saliva, such as sharing drinks. Symptoms of herpes simplex virus infection include watery blisters in the skin or mucous membranes of the mouth, lips or genitals. Lesions heal with ascab characteristic of herpetic disease. As neurotropic and neuroinvasive viruses, HSV-1 and -2 persist in the body by becoming latent and hiding from the immune system in the cell bodies of neurons. After the initial or primary infection, some infected people experience sporadic episodes of viral reactivation or outbreaks.

HSV Isoform Specific Products:

HSV Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-126218
    HSV-TK substrate
    HSV-TK substrate is a substrate for HSV-TK, and induces multi-log cytotoxicity in HSV-TK-expressing and bystander cells. HSV-TK substrate shows antitumor activity.
    HSV-TK substrate
  • HY-W766548
    Floxuridine-13C,15N2
    Floxuridine-13C,15N2 (5-Fluorouracil 2'-deoxyriboside-13C,15N2) is the 13C- and 15N-labeled labeled Floxuridine (HY-B0097). Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis. Floxuridine has antiviral effects against HSV and CMV.
    Floxuridine-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-N7040
    11-Deoxymogroside IIE
    		Inhibitor
    11-Deoxymogroside IIE is a cucurbitane glycoside, isolated from Siraitia grosvenorii fruits. 11-Deoxymogroside IIE has inhibitory effect against Epstein Barr virus (EBV-EA) activation induced by TPA, shows weak inhibitory effect on (+/-)-(E)-methyl1-2-[E-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR1), a NO donor.
    11-Deoxymogroside IIE
  • HY-N10177
    Peniterphenyl A
    		Inhibitor
    Peniterphenyl A is a natural product obtained from a deep-sea-derived Penicillium sp. Peniterphenyl A inhibits HSV-1/2 virus entry into cells and may block HSV-1/2 infection through direct interaction with virus envelope glycoprotein D to interfere with virus adsorption and membrane fusion. Peniterphenyl A is a promising lead compound against HSV-1/2.
    Peniterphenyl A
  • HY-W713297
    Moroxydine hydrochloride-d8
    		Inhibitor
    Moroxydine hydrochloride-d8 (ABOB hydrochloride-d8) is the deuterium labeled Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels[1][2][3].
    Moroxydine hydrochloride-d<sub>8</sub>
  • HY-B0222S
    1-Docosanol-d45
    		Inhibitor
    1-Docosanol-d45 is the deuterium labeled 1-Docosanol. 1-Docosanol is a saturated fatty alcohol used traditionally as an emollient, emulsifier, and thickener in cosmetics, and nutritional supplement. 1-Docosanol is an inhibitor of lipid-enveloped viruses including herpes simplex.
    1-Docosanol-d<sub>45</sub>
  • HY-105102
    Netivudine
    		Inhibitor
    Netivudine is a nucleoside analogue with potent anti-varicella zoster virus activity. Netivudine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Netivudine
  • HY-P4318
    HHV-2 Envelope Glycoprotein G (552-574)
    HHV-2 Envelope Glycoprotein G (552-574) is an immunodominant region of glycoprotein G (gG-2) reactive with all herpes simplex (HSV-2) sera.
    HHV-2 Envelope Glycoprotein G (552-574)
  • HY-N3254
    Minumicrolin
    		Inhibitor
    Minumicrolin is a plant growth inhibitor. Minumicrolin can be isolated from Murraya paniculata. Minumicrolin inhibits Epstein-Barr virus early antigen (EBV-EA) activation.
    Minumicrolin
  • HY-W017522S6
    Adipic acid-13C2
    		Inhibitor
    Adipic acid-13C2 (Hexanedioic acid-13C2) is 13C labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc.
    Adipic acid-<sup>13</sup>C<sub>2</sub>
  • HY-N6666R
    Vidarabine monohydrate (Standard)
    		Inhibitor
    Vidarabine (monohydrate) (Standard) is the analytical standard of Vidarabine (monohydrate). This product is intended for research and analytical applications. Vidarabine monohydrate is an adenine arabinoside. Vidarabine monohydrate an antiviral agent which is active against herpes simplex viruses (HSV) and varicella zoster viruses[1].
    Vidarabine monohydrate (Standard)
  • HY-113289R
    Brassicasterol (Standard)
    		Inhibitor
    L-Ornithine (hydrochloride) (Standard) is the analytical standard of L-Ornithine (hydrochloride). This product is intended for research and analytical applications. L-Ornithine hydrochloride is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine hydrochloride shows nephroprotective.
    Brassicasterol (Standard)
  • HY-P991072
    MB-66
    		Inhibitor
    MB-66 (MAPP-66) is a fully human IgG1 antibody that targets HSV and HIV. MB-66 is a monoclonal antibody film for vaginal application. The isotype control for MB-66 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    MB-66
  • HY-123211
    WAY-150138
    		Inhibitor
    WAY-150138 inhibits replication of herpes simplex virus type 1 (HSV-1) that acts by preventing the incorporation of DNA-packaging proteins into capsids as they are assembled
    WAY-150138
  • HY-17422B
    Acyclovir monophosphate
    		Inhibitor
    Acyclovir monophosphate is a potent anti-herpes simplex virus (HSV) agent. Acyclovir monophosphate blocks DNA synthesis through the inhibition of the viral DNA polymerase and terminates the chain elongation of the viral DNA. Acyclovir monophosphate shows antitumor activity.
    Acyclovir monophosphate
  • HY-152535
    ATV041
    ATV041 is an orally active Ibuprofen (HY-78131) and nucleotide analogue. ATV041 improves oral pharmacokinetic (PK) profile and tissue distribution with anti-mouse hepatitis virus (MHV) activity. ATV041 reduces viral load, tissue damage and virus-induced inflammation in a dose-dependent manner.
    ATV041
  • HY-B1773AR
    Sodium propionate (Standard)
    		Inhibitor
    Sodium propionate (Standard) is the analytical standard of Sodium propionate. This product is intended for research and analytical applications. Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease.
    Sodium propionate (Standard)
  • HY-149023
    HSV-1/HSV-2-IN-2
    		Inhibitor
    HSV-1/HSV-2-IN-2 is a HSV-1, HSV-2 and VV inhibitor with EC50 values of 6.8, 8.9 and 8.9 µM, respectively.
    HSV-1/HSV-2-IN-2 shows antiviral activity.
    HSV-1/HSV-2-IN-2
  • HY-17425AS
    Valacyclovir-d8 hydrochloride
    		Inhibitor 98.0%
    Valacyclovir-d8 (hydrochloride) is the deuterium labeled Valacyclovir hydrochloride. Valacyclovir hydrochloride (Valaciclovir hydrochloride) is an orally active antiviral agent for herpes simplex, herpes zoster, and herpes B. Valacyclovir hydrochloride inhibits HSV-1 W (50=2.9 μg/ml). Valacyclovir hydrochloride is a proagent of Aciclovir (HY-17422) .
    Valacyclovir-d<sub>8</sub> hydrochloride
  • HY-177638A
    ISIS 1082 sodium
    		Inhibitor
    ISIS 1082 sodium is an antisense oligonucleotide targeted to the translation initiation codon of herpes simplex virus (HSV) type 1 and 2 virion capsid protein. It has been shown to inhibit HSV-1 replication in vitro
    ISIS 1082 sodium
HSV Isoform Comparison

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