2. Signaling Pathways
  3. Stem Cell/Wnt
  4. Gli
  5. Gli Antagonist

Gli Antagonist

Gli Antagonists (2):

Cat. No. Product Name Effect Purity
  • HY-13282
    GANT 58
    		Antagonist 99.37%
    GANT 58 (NSC 75503) is a potent GLI antagonist that inhibits GLI1-induced transcription with IC50 of 5 μM.
  • HY-107551
    Hh Pathway-IN-1
    		Antagonist 99.06%
    Hh Pathway-IN-1, a Hedgehog (Hh) pathway inhibitor, is a potent Gli antagonist. Hh Pathway-IN-1 inhibits Hh pathway functional with an IC50 value of 1.1 µM in C3H10T1/2 cells. Hh Pathway-IN-1 does not inhibit Wnt signaling. Hh Pathway-IN-1 shows anti-proliferative activity. Hh Pathway-IN-1 decreases the GLI1 mRNA expression. Hh Pathway-IN-1 inhibits colony formation in a dose-dependent manner.