2. Signaling Pathways
  3. GPCR/G Protein
  4. Free Fatty Acid Receptor
  5. Free Fatty Acid Receptor Activator

Free Fatty Acid Receptor Activator

Free Fatty Acid Receptor Activators (6):

Cat. No. Product Name Effect Purity
  • HY-10480
    Fasiglifam
    		Activator 98.97%
    Fasiglifam (TAK-875) is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 72 nM.
  • HY-12647
    GPR40 Activator 2
    		Activator 99.63%
    GPR40 Activator 2 is a potent GPR40 activator from patents WO 2012147516 A1, WO 2012046869A1 and WO 2011078371 A1.
  • HY-172944
    GPR40 Activator 3
    		Activator
    GPR40 Activator 3 (compound SC) is a potent GPR40 activator. GPR40 Activator 3 mitigates pulmonary fibrosis by inhibiting M2 macrophage polarization via the GPR40/PKD1/CD36 axis.
  • HY-176733
    HDAC6-IN-61
    		Activator
    HDAC6-IN-61 (Compound 4e) is a HDAC6 inhibitor (IC50: 73 nM) with selectivity over other HDAC isoforms. HDAC6-IN-61 is also a GPR40 activator. HDAC6-IN-61 increases acetylated tubulin and ERK phosphorylation levels. HDAC6-IN-61 can be used for research of neuroinflammation such as Alzheimer's disease.
  • HY-13971
    GPR40 Activator 1
    		Activator 98.81%
    GPR40 Activator 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • HY-W010655
    Fasiglifam hemihydrate
    		Activator
    Fasiglifam (TAK-875) hemihydrate is a potent, selective and orally active GPR40 agonist with EC50 of 72 nM. Fasiglifam enhances glucose-dependent insulin secretion and improves hyperglycemia in type 2 diabetic rats. Fasiglifam can induce liver injury.