2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-105751
    Kalafungin
    		Inhibitor
    Kalafungin is an antibiotic, antimicrobial agent and a β-lactamase inhibitor from marine Streptomyces, with IC50 of 225.37 μM. Kalafungin destroys cell membranes. Kalafungin shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria (such as S. aureus ATCC 33591 and S. aureus ATCC 23591), and, to a lesser extent, gram-negative bacteria.
    Kalafungin
  • HY-119683R
    Epoxiconazole (Standard)
    		Inhibitor
    Epoxiconazole (Standard) is the analytical standard of Epoxiconazole. This product is intended for research and analytical applications. Epoxiconazole, a fungicide, is a demethylation inhibitor of the Ergosterol biosynthesis pathway. Epoxiconazole exhibits strong inhibitory effects on both carbendazim-resistant and phenamacril-resistant isolates, and can be used for controlling many crop diseases.
    Epoxiconazole (Standard)
  • HY-N15107
    Polyoxin M
    		Inhibitor
    Polyoxin M is a nucleoside antifungal antibiotic and has significant effects on rice sheath blight.
    Polyoxin M
  • HY-138210
    N,O-Diacetyltyramine
    		Inhibitor
    N,O-Diacetyltyramine is a compound with antibacterial activity and cytotoxicity that can be isolated from the actinomycete Pseudonocardia endophytica VUK-10. N,O-Diacetyltyramine has antibacterial activity against Gram-positive and Gram-negative bacteria and fungi. N,O-Diacetyltyramine is cytotoxic to MDA-MB-231, HeLa, MCF-7 and OAW-42 cells.
    N,O-Diacetyltyramine
  • HY-B2064R
    Carboxin (Standard)
    		Inhibitor
    Carboxin (Standard) is the analytical standard of Carboxin. This product is intended for research and analytical applications. Carboxin (Carboxine) is a systemic agricultural fungicide and seed protectant.
    Carboxin (Standard)
  • HY-N14054
    Chondramide D
    		Inhibitor
    Chondramide D has anti-candida, Henson yeast, lipids yeast, ball-like yeast and other fungal activities, but has no anti-Gram positive and negative bacteria activities.
    Chondramide D
  • HY-N14043
    Crocacin C
    		Inhibitor
    Crocacin C has anti-yeast and filamentous fungal activity. Crocacin C can inhibit mouse fibroblasts L929. In the microsomes of the calf's heart, Crocacin C can interrupt the bc1 segment of electronic transmission, causes redshift of 569 nm peak in cytochrome B reduction spectrum.
    Crocacin C
  • HY-157446
    MoTPS1/2-IN-1
    		Inhibitor
    MoTPS1/2-IN-1 (Compound A1-4 ) is a bispecific inhibitor of MoTps1 and MoTps2. MoTPS1/2-IN-1 has antifungal activity and showed good inhibitory activity against the growth and virulence of B. cinerea and F. graminearum.
    MoTPS1/2-IN-1
  • HY-135438
    Mollugogenol A
    		Inhibitor
    Mollugogenol A is a fungal inhibitor. Mollugogenol A can cause damage to sperm membranes by increasing lipid peroxidation, exhibiting sperm-killing activity.
    Mollugogenol A
  • HY-N14324
    Hydranthomycin
    		Inhibitor
    Hydranthomycin is an antibiotic. Hydranthomycin has moderate antifungal activity, and the MIC of Pyricularia oryzae is 25 μg/mL. Hydranthomycin inhibits the growth of Euglena gracilis and has herbicidal activity.
    Hydranthomycin
  • HY-129155
    (Rac)-Germacrene D
    (Rac)-Germacrene D is a natural product that can be isolated from the genus Bursera.
    (Rac)-Germacrene D
  • HY-136764
    CYP51-IN-14
    		Inhibitor
    CYP51-IN-2 (compound 1n), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 1 μg/mL for Microsporum gypseum and Candida albicans.
    CYP51-IN-14
  • HY-N1448R
    Vincetoxicoside B (Standard)
    		Inhibitor
    Vincetoxicoside B (Standard) is the analytical standard of Vincetoxicoside B. This product is intended for research and analytical applications. Vincetoxicoside B shows antifungal activity.
    Vincetoxicoside B (Standard)
  • HY-169987
    bc1 Complex-IN-1
    		Inhibitor
    bc1 Complex-IN-1 (compound 12g) is a potent bc1 complex inhibitor. bc1 Complex-IN-1 shows fungicidal properties against Cucumber downy mildew (CDM).
    bc1 Complex-IN-1
  • HY-B0537A
    Pentamidine dihydrochloride
    		Inhibitor
    Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities.
    Pentamidine dihydrochloride
  • HY-167831
    Vermistatin
    Vermistatin is a metabolite of the fungal strain Guignardia that has cytotoxic and antifungal activity.
    Vermistatin
  • HY-169510
    Aurachin C
    		Inhibitor
    Aurachin C is an isoprenoid quinoline alkaloid with antiplasmodial, antifungal and antibacterial effects. Aurachin C is a selective terminal oxidases inhibitor.
    Aurachin C
  • HY-N5185
    Cyclothiazomycin
    		Inhibitor
    Cyclothiazomycin selectively inhibits renin activity and does not inhibit pepsin, aspartic acid, serine, mercaptan protease and metalloproteinases. Cyclothiazomycin has weak antifungal activity.
    Cyclothiazomycin
  • HY-157729
    1-Undecanoylglycerol
    		Inhibitor
    1-Undecanoylglycerol is a monoacylglycerol with antibacterial activity, which can be used in food additives research.
    1-Undecanoylglycerol
  • HY-N14669
    Cladospolide D
    		Inhibitor
    Cladospolide D is found in the strain of Cladosporium sp. FT-0012. Cladospolide D has the activity against part of fungi.
    Cladospolide D
Cat. No. Product Name / Synonyms Application Reactivity