2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-169119
    Antifungal agent 114
    		Inhibitor
    Antifungal agent 114 (Compound 19g) is an inhibitor for Cytochrome P450, that inhibits CYP1A2, CYP2C9, CYP2C19 CYP2D6 and CYP3A4 at 10 μM. Antifungal agent 114 exhibits antifungal activity against Cryptococcus neoformans, Candida and Aspergillus, with MIC <0.0625 μg/mL. Antifungal agent 114 exhibits good metabolic stability in human liver microsomes with a half-time of 107 minutes.
    Antifungal agent 114
  • HY-N15062
    2-Hydroxymethylclavam
    		Inhibitor
    2-Hydroxymethylclavam is a β-lactam antibiotic. 2-Hydroxymethylclavam has antifungal activity, especially for plant pathogenic fungi.
    2-Hydroxymethylclavam
  • HY-N1500R
    Pulegone (Standard)
    		Inhibitor
    Pulegone (Standard) is the analytical standard of Pulegone (HY-N1500). This product is intended for research and analytical applications. Pulegone is a monoterpene ketone compound widely present in the essential oils of many plants. Pulegone can also be used as a bird repellent. Pulegone has multiple activities such as anti-inflammatory, antibacterial, antifungal, and anti-hyperalgesic effects. Pulegone is particularly effective against bacteria of the Salmonella species.
    Pulegone (Standard)
  • HY-114551
    Streptothricin E
    		Inhibitor
    Racemomycin C has broad spectrum antibacterial activity and antifungal effect, and it can inhibit PR-8 of influenza virus in tissue culture.
    Streptothricin E
  • HY-134215
    cis-11-Methyl-2-dodecenoic acid
    		Modulator
    cis-11-Methyl-2-dodecenoic acid is a quorum sensing (QS) signal that acts as a diffusion signaling factor (DSF) in extracellular microbial and fungal communication systems. DSF is involved in the regulation of virulence and biofilm formation of a variety of bacterial pathogens.
    cis-11-Methyl-2-dodecenoic acid
  • HY-N14858
    Neosordarin
    		Inhibitor
    Neosordarin has antifungal activity and inhibits S. Cerevisia with the IC50 of 0.2~0.3 μg/mL.
    Neosordarin
  • HY-123474
    PF-1163B
    		Inhibitor
    PF-1163B is an antifungal antibiotic.
    PF-1163B
  • HY-162953
    Laccase-IN-4
    		Inhibitor
    Laccase-IN-4 (compund 5g) exhibits significant Laccase inhibitory activity.
    Laccase-IN-4
  • HY-164643
    Antifungal agent 113
    		Inhibitor
    Antifungal agent 113 (compound 9a) is a potent antifungal and antibacterial agent. Antifungal agent 113 shows good antibacterial activity against S. aureus and methicillin-resistant S. aureus.
    Antifungal agent 113
  • HY-155167
    Anticancer agent 151
    		Inhibitor
    Anticancer agent 151 (compound 6C) is an anticancer agent. Anticancer agent 151 exhibits excellent in vitro cytotoxic activity against MCF-7 cells with an IC50 value of 6.3 μM.
    Anticancer agent 151
  • HY-N14066
    Ascochitine
    		Inhibitor
    Ascochitine, a polyketide-derived secondary metabolite, is a selective antifungal agent. Ascochitine exhibits broad-spectrum phytotoxicity and antimicrobial activities.
    Ascochitine
  • HY-136757
    CYP51-IN-7
    		Inhibitor
    CYP51-IN-2 (compound 1g), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 62.5 and 250 ng/mL for Microsporum gypseum and Candida albicans, respectively.
    CYP51-IN-7
  • HY-121633
    Kayahope
    		Inhibitor
    Kayahope is a fungal inhibitor.
    Kayahope
  • HY-121395
    Lepiochlorin
    		Inhibitor
    Lepiochlorin is an antibiotic metabolite produced by a fungus (Lepiota species) that is cultivated by ants, which can prevent fungal contamination.
    Lepiochlorin
  • HY-N15183
    Aselacin C
    Aselacin C is a cyclic peptide that can be isolated from the fungus Acremonium spp..
    Aselacin C
  • HY-N14216
    Polyoxin L
    		Inhibitor
    Polyoxin L is a nucleoside antifungal antibiotic and has significant effects on rice sheath blight.
    Polyoxin L
  • HY-17520R
    Penthiopyrad (Standard)
    		Inhibitor
    Penthiopyrad (Standard) is the analytical standard of Penthiopyrad. This product is intended for research and analytical applications. Penthiopyrad (MTF-753) is a chiral carboxamide antifungal agent with a broad spectrum of fungicidal activity. Penthiopyrad can be used for controlling foliar and soil-borne plants diseases on a broad range of agricultural crops and turfgrass.
    Penthiopyrad (Standard)
  • HY-14272S
    Ravuconazole-d4
    		Inhibitor
    Ravuconazole-d4 is the deuterium labeled Ravuconazole. Ravuconazole (BMS-207147) is an orally available triazoleantifungle agent that potently inhibits a wide range of fungi.
    Ravuconazole-d<sub>4</sub>
  • HY-N14318
    Feigrisolide B
    		Inhibitor
    Feigrisolide B is a lactone found in Streptomyces griseus. Feigrisolide B has the activity of resisting Sporobolomyces ochreata and inhibiting CoxsacKie virus B3. Feigrisolide B also has moderate inhibitory activity of 3α-hydroxysterol dehydrogenase.
    Feigrisolide B
  • HY-N8511
    Acremine I
    		Inhibitor
    Acremine I is a fungi inhibitor and also a metabolite of the endophytic fungus Acremonium byssoides. Acremine I can effectively inhibit Plasmopara viticola. Acremine I can be used for research on plant diseases, such as grape downy mildew.
    Acremine I
Cat. No. Product Name / Synonyms Application Reactivity