2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10219R
    Rapamycin (Standard)
    		Inhibitor
    Rapamycin (Standard) is the analytical standard of Rapamycin. This product is intended for research and analytical applications. Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.
    Rapamycin (Standard)
  • HY-N0068
    Solasodine
    		Inhibitor 99.81%
    Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities.
    Solasodine
  • HY-N6647
    Luteolin-7-rutinoside
    		99.10%
    Luteolin-7-rutinoside has both anti-arthritic and antifungal activities, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.
    Luteolin-7-rutinoside
  • HY-P4855
    CRAMP (mouse)
    		98.97%
    CRAMP (mouse) is an antimicrobial peptide. CRAMP (mouse) can be used for the research of biofilm-associated infections.
    CRAMP (mouse)
  • HY-N4136
    Lonicerin
    		Inhibitor 99.77%
    Lonicerin (Veronicastroside) is a flavonoid with multiple biological activities. Lonicerin inhibits xanthine oxidase with an IC50 of 37.4 µg/mL. Lonicerin inhibits alginate secretion protein (AlgE). Lonicerin inhibits P. aeruginosa and C. albicans. Lonicerin has anti-inflammatory, anti-arthritic, antioxidant, antifungal, anti-bacterial, and neuroprotective properties.
    Lonicerin
  • HY-W088075
    Acriflavine hydrochloride
    		Inhibitor 99.4%
    Acriflavine (Acriflavinium chloride) hydrochloride is a fluorescent acridine dye that can be used to label nucleic acid. Acriflavine hydrochloride is an antiseptic agent. Acriflavine hydrochloride is a potent HIF-1 inhibitor that prevents the dimerization of HIF-1α and HIF-1β subunits. Acriflavine hydrochloride inhibits the interaction between monocarboxylate transporter 4 (MCT4) and Basigin. Acriflavine hydrochloride is used in cancer research, such as breast cancer, brain tumor and chronic myeloid leukemia. Acriflavine hydrochloride is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2.
    Acriflavine hydrochloride
  • HY-B0454A
    Miconazole nitrate
    		Inhibitor 99.75%
    Miconazole nitrate (R18134 nitrate) is an imidazole antifungal agent. Miconazole nitrate also has antibacterial effects.
    Miconazole nitrate
  • HY-N1063
    Xanthoxylin
    		Inhibitor 99.84%
    Xanthoxylin (Xanthoxyline) can be isolated from Zanthoxylum simulans. Xanthoxylin has antifungal and antioxidant effects. The MIC of Xanthoxylin against Toxoplasma neonatorum and Aspergillus fumigatus were 50 µg/mL and 75 µg/mL, respectively. Xanthoxylin can be used in the study of anti-epileptic diseases.
    Xanthoxylin
  • HY-W004282
    Undecanoic acid
    		Inhibitor 99.97%
    Undecanoic acid (Undecanoate) is a monocarboxylic acid with antifungal property. Undecanoic acid inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum.
    Undecanoic acid
  • HY-119683
    Epoxiconazole
    		Inhibitor 98.95%
    Epoxiconazole, a fungicide, is a demethylation inhibitor of the Ergosterol biosynthesis pathway. Epoxiconazole exhibits strong inhibitory effects on both carbendazim-resistant and phenamacril-resistant isolates, and can be used for controlling many crop diseases.
    Epoxiconazole
  • HY-Y0569C
    D-Gluconic acid potassium
    		Inhibitor ≥98.0%
    D-Gluconic acid potassium is an orally active carboxylic acid by the oxidation with antiseptic and chelating properties.
    D-Gluconic acid potassium
  • HY-P0270
    Magainin 2
    		Inhibitor 98.92%
    Magainin 2 (Magainin II) is an antimicrobial peptide (AMP) isolated from the skin of the African clawed frog Xenopus laevis. Magainin 2 displays antibiotic activity against numerous gram-negative and gram-positive bacteria. Magainin 2 also is active against protozoa. Magainin 2 exerts its cytotoxicity effects by preferential interactions with anionic phospholipids abundant in bacterial membranes.
    Magainin 2
  • HY-B1539A
    Fuchsine base monohydrochloride
    		Inhibitor 99.53%
    Fuchsine base (Magenta base; Basic Fuchsin) monohydrochloride is a triaminotriphenylmethane dye. Fuchsine base monohydrochloride has anesthetic, bactericidal and fungicidal properties. Fuchsine base monohydrochloride can be used for the staining of collagen, muscle, mitochondria and tuberculosis. Fuchsine base monohydrochloride is widely used for the dyeing of textiles and leather materials.
    Fuchsine base monohydrochloride
  • HY-B0849
    Azoxystrobin
    		Inhibitor 99.03%
    Azoxystrobin is an orally active, broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.
    Azoxystrobin
  • HY-17643
    Oteseconazole
    		Inhibitor 99.46%
    Oteseconazole (VT-1161) is a potent and orally active anti-fungal agent. Oteseconazole potently binds to and inhibits Candida albicans cytochrome P45051 (CYP51) activity (Kd ≤39 nM), shows no obvious effect on human CYP51. Oteseconazole also can be used for the research of dermatophytes.
    Oteseconazole
  • HY-N1422
    Hecogenin
    		Inhibitor 99.96%
    Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects.
    Hecogenin
  • HY-N5142
    α-Terpineol
    		Inhibitor 99.47%
    α-Terpineol (with oral activity) can be found in Eucalyptus globulus Labill. α-Terpineol exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria.α-Terpineol possesses antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption. In addition, α-Terpineol exhibits antineuropathic and anti-inflammatory activities. α-Terpineol can be utilized in research related to diarrhea, neuropathic pain, infections, and inflammation.
    α-Terpineol
  • HY-W017316
    Terpinen-4-ol
    		98.58%
    Terpinen-4-ol (4-Carvomenthenol) is a naturally occurring monoterpene, and can be extracted from a variety of aromatic plants. Terpinen-4-ol is a potent bactericidal agent which possess antifungal , anti-inflammatory and antitumor properties as well, suggesting Terpinen-4-ol to be used for relevant research.
    Terpinen-4-ol
  • HY-111919
    3-Nitrocoumarin
    		Inhibitor 98.52%
    3-Nitrocoumarin is an inhibitor for phospholipase C that blocks the generation of inositol triphosphate (IP3), thereby affecting the calcium signaling pathway.
    3-Nitrocoumarin
  • HY-N7151
    Aurachin D
    		Inhibitor 99.62%
    Aurachin D is an antibiotic. Aurachin D inhibits Gram-positive bacteria and a few funguses. Aurachin D blocks NADH oxidation in beef heart submitochondrial particles.
    Aurachin D
Cat. No. Product Name / Synonyms Application Reactivity