2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N1039
    13-Epimanool
    		Inhibitor
    13-Epimanool is the compound isolated from the bark of the Taiwan hemlock.
    13-Epimanool
  • HY-B0852R
    Tebuconazole (Standard)
    		Inhibitor
    Tebuconazole (Standard) is the analytical standard of Tebuconazole. This product is intended for research and analytical applications. Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells.
    Tebuconazole (Standard)
  • HY-162521
    Antibacterial agent 215
    		Inhibitor
    Antibacterial agent 215 (Compound 3b) is an inhibitor for carbonic anhydrase (CA), with Ki of 17.61, 5.14 and 43.74 nM, for hCA I, hCA II and AChE, respectively. Antibacterial agent 215 exhibits anti-tuberculosis, with MIC of 62.5 µg/ml against M. tuberculosis. Antibacterial agent 215 exhibits antifungal activities against Candida spp. strains ATCC 14053, ATCC 1369, and ATCC 15126, with MICs of 125 µg/ml.
    Antibacterial agent 215
  • HY-N12201
    Funiculosin
    		Inhibitor
    Funiculosin is a neutral lipophilic antibiotic that inhibits DNA and RNA viruses. Funiculosin also has antifungal activity. Funiculosin inhibits infections caused by pathogenic fungi in primary chicken embryo fibroblasts.
    Funiculosin
  • HY-132968
    Antifungal agent 20
    		Inhibitor
    Antifungal agent 20 exhibits remarkable antifungal activity against Colletotrichum gloeosprioides, Rhizoctonia solani, Phytophthora nicotianae var. nicotianae, Diplodia pinea, Colletotrichum acutatum, and Fusarium oxysporum f. sp. niveum.
    Antifungal agent 20
  • HY-N14249
    Melithiazole B
    		Inhibitor
    Melithiazol B is an antibiotic. Melithiazole B is a β-methoxyacrylate (MOA) inhibitor with strong anti-agent activity. Antifungal and cytotoxic agent.
    Melithiazole B
  • HY-N13284
    13-Hydroxy-9-octadecenoic acid
    		Inhibitor
    13-Hydroxy-9-octadecenoic acid is a hydroxy unsaturated fatty acid (HUFA) that has anti-fungal activity.
    13-Hydroxy-9-octadecenoic acid
  • HY-N14936
    AK-toxin Ⅰ
    		Inhibitor
    AK-toxin I is a host-specific phytotoxic metabolite. AK-toxin I causes black spot disease of pear trees.
    AK-toxin Ⅰ
  • HY-N2584AR
    Isoxanthohumol (Standard)
    		Inhibitor
    Isoxanthohumol (Standard) is the analytical standard of Isoxanthohumol (HY-N2584A). This product is intended for research and analytical applications. Isoxanthohumol is an orally active flavonoid compound. Isoxanthohumol has biological activities such as anti-tumor, anti-inflammatory, antioxidant, antiviral, antifungal, and inhibition of adipogenesis. Isoxanthohumol can induce apoptosis, autophagy, and migration of tumor cells. Isoxanthohumol is active against viruses such as HSV, BVDV, CMV, and Rhino. Isoxanthohumol can be used for the research of tumors, metabolic, and inflammatory diseases.
    Isoxanthohumol (Standard)
  • HY-129331
    Neothramycin A
    		Inhibitor
    Neothramycin A is an antibiotic, which can be isolated from Streptomyces. Neothramycin A exhibits board spectrum antimicrobial activity, inhibits Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli W677, and Saccharomyces cerevisia with MIC of 25-50 μg/mL. Neothramycin A exhibits antitumor efficacy against leukemia in mouse models.
    Neothramycin A
  • HY-137084
    Antibiotic AB023a
    		Inhibitor
    Antibiotic AB023a is part of macrocyclic pentaene antibiotic complex, forming the main components with Antibiotic AB023b (HY-137085). Antibiotic AB023a exhibits antifungal activity against Candida albicans, and plant pathogenic fungi, Botrytis cinerea (MIC= 5 μg/mL), Fusarium moniliforme and Pythium ultimum.
    Antibiotic AB023a
  • HY-N12681
    Phoslactomycin A
    		Inhibitor
    Phoslactomycin A has weak effect against Gram-positive bacteria, but has strong effect against fungi.
    Phoslactomycin A
  • HY-N14157
    Epelmycin C
    		Inhibitor
    Epelmycin C has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin.
    Epelmycin C
  • HY-N14829
    Naphthoquinomycin A
    		Inhibitor
    Naphthoquinomycin A is an Ansa antibiotic with anti-Gram-positive bacteria and fungi activity, and can inhibit the synthesis of E. coli fatty acids.
    Naphthoquinomycin A
  • HY-117869
    AFK-108
    AFK-108 is a potent antifungal agent. AFK-108 inhibits the activity of 14 alpha-demethylase.
    AFK-108
  • HY-167834
    Farinomalein A
    		Inhibitor
    Farinomalein A is a maleimide that can be isolated from Paecilomyces farinosus. Farinomalein A has potent inhibition of Phytophtora sojae.
    Farinomalein A
  • HY-121109
    Benalaxyl
    		Inhibitor 99.86%
    Benalaxyl is a fungicide. Benalaxyl has good control of blue mould (Peronospora tubacina).
    Benalaxyl
  • HY-120729
    Pyrazophos
    		Inhibitor
    Pyrazophos (Curamil) is a slightly systemic fungicide against the powdery mildew on crops and cereals. Pyrazophos is widely used in Greece to control diseases caused by Erysiphe spp., Sphaerotheca spp., Leveillula spp. and Oidium spp..
    Pyrazophos
  • HY-129060R
    Flutrimazole (Standard)
    Flutrimazole (Standard) is the analytical standard of Flutrimazole. This product is intended for research and analytical applications. Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole shows scarce transdermal penetration. Flutrimazole has the advantageous in the research of topical fungal infections with an inflammatory component.
    Flutrimazole (Standard)
  • HY-131044
    5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione
    		Inhibitor
    5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione (Compound 4) has antimicrobial, anti-diabetic and antioxidant activities. 5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione inhibits B. subtilis, S. aureus, K. pneumonia, E. coli, and S. typhi with MICs of 4.5-9.9 μΜ/mL, and inhibits A. niger and C. albicans with MICs of 4.99 μΜ/mL.
    5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione
Cat. No. Product Name / Synonyms Application Reactivity