2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

PDF 2.4 MB

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-168077
    Antibiofilm agent-12
    Antibiofilm agent-12 (Compound C13) is an antifungal agent that belongs to the class of carbazate derivatives. Antibiofilm agent-12 exhibits significant antifungal activity against Candida auris, with a MIC90 of 237.9 μM. By inhibiting the drug efflux pump activity of Candida auris and promoting ergosterol depletion, Antibiofilm agent-12 hinders biofilm formation and reduces the metabolic flexibility of Candida auris. Additionally, Antibiofilm agent-12 demonstrates antifungal activity in a Candida auris-infected C. elegans model.
    Antibiofilm agent-12
  • HY-124250
    9-OxoOTrE
    		Inhibitor
    9-OxoOTrE (9-KOTrE) is an antifungal agent against B. cinerea, C. herbarum, P. infestans, and P. parasitica, through a mechanism based on their electrophilic nature.
    9-OxoOTrE
  • HY-149600
    SDH-IN-7
    		Inhibitor
    SDH-IN-7 (compound G28) is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 26 nM for porcine SDH. SDH-IN-7 has fungicidal properties.
    SDH-IN-7
  • HY-Y0569CR
    D-Gluconic acid potassium (Standard)
    		Inhibitor
    D-Gluconic acid (potassium) (Standard) is the analytical standard of D-Gluconic acid (potassium). This product is intended for research and analytical applications. D-Gluconic acid potassium is an orally active carboxylic acid by the oxidation with antiseptic and chelating properties.
    D-Gluconic acid potassium (Standard)
  • HY-W017277R
    (+)-Menthol (Standard)
    		Inhibitor
    (+)-Menthol (Standard) is the analytical standard of (+)-Menthol. This product is intended for research and analytical applications. (+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol inhibits fungal growth and sporulation. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells.
    (+)-Menthol (Standard)
  • HY-161921
    Antifungal agent 108
    		Inhibitor
    Antifungal agent 108 (compound 14d), an original imidazo[1,2-b]pyridazine derivative, shows potent antifungal activity against Madurella mycetomatis (MM55 strain) with an IC50 of 0.9 μM. Antifungal agent 108 exhibits an IC50 of 14.3 μM on cell viability of NIH-3T3 murine fibroblast.
    Antifungal agent 108
  • HY-Y1825R
    Benzimidazole (Standard)
    		Inhibitor
    Benzimidazole (Standard) is the analytical standard of Benzimidazole. This product is intended for research and analytical applications. Benzimidazole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Benzimidazole (Standard)
  • HY-123510
    NSC-670224
    		Inhibitor
    NSC-670224 is toxic to Saccharomyces cerevisiae at low micromolar concentration (LC50: 3.2 μM).
    NSC-670224
  • HY-N7123S1
    Sulfacetamide-13C6
    		Inhibitor
    Sulfacetamide-13C6 (Sulphacetamide13C6) is the 13C6 labeled Sulfacetamide (HY-N7123). Sulfacetamide (Sulphacetamide) is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide has antifungal and antibacterial activities.
    Sulfacetamide-<sup>13</sup>C<sub>6</sub>
  • HY-136355S
    Picoxystrobin-d3
    		Inhibitor
    Picoxystrobin-d3 is the deuterium labeled Picoxystrobin (HY-136355). Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity.
    Picoxystrobin-d<sub>3</sub>
  • HY-N6038R
    Gartanin (Standard)
    Gartanin (Standard) is the analytical standard of Gartanin. This product is intended for research and analytical applications. Gartanin is a natural xanthone of mangosteen, with antioxidant, anti-inflammatory, antifungal, neuroprotective and antineoplastic properties. Gartanin induces cell cycle arrest and autophagy and suppresses migration in human glioma cells.
    Gartanin (Standard)
  • HY-123720
    Sch 31828
    		Inhibitor
    Sch 31828 is a novel antifungal antibiotic, with mean MICs against Candida of 0.034 /g/mL.
    Sch 31828
  • HY-125969
    Rtt109 inhibitor 1
    		Inhibitor
    Rtt109 inhibitor 1 (Compound 1) is an inhibitor for histone acetyltransferase Rtt109 through a tight binding, uncompetitive system. Rtt109 inhibitor 1 exhibits antifungal activity through acetylation at H3K56 site.
    Rtt109 inhibitor 1
  • HY-B2026
    Propamocarb
    		Inhibitor
    Propamocarb is a systemic fungicide. Propamocarb is widely used to protect cucumbers, tomatoes and other plants from pathogens.
    Propamocarb
  • HY-N12682
    Phoslactomycin C
    		Inhibitor
    Phoslactomycin C has weak effect against Gram-positive bacteria, but has strong effect against fungi.
    Phoslactomycin C
  • HY-N1289
    Sequosempervirin B
    		Inhibitor
    Sequosempervirin B, a norlignan isolated from the branches and leaves of Sequoia sempervirens, has antifungal properties. Sequosempervirin B has an inhibitory effect on cyclic AMP phosphodiesterase.
    Sequosempervirin B
  • HY-151423
    Antifungal agent 39
    		Inhibitor
    Antifungal agent 39 (Compound 9h) is a broad-spectrum antifungal agent.
    Antifungal agent 39
  • HY-N6635R
    trans-Nerolidol (Standard)
    		Inhibitor
    trans-Nerolidol (Standard) is the analytical standard of trans-Nerolidol. This product is intended for research and analytical applications. trans-Nerolidol improves the anti-proliferative effect of Doxorubicin (DOX) (HY-15142A) against intestinal cancer and breast cancer cells in vitro. trans-Nerolidol increases accumulation of DOX inside cells in vitro. trans-Nerolidol activates apoptosis in vivo.
    trans-Nerolidol (Standard)
  • HY-139161
    Penflufen
    		Inhibitor 99.70%
    Penflufen is a highly efficient, broad-spectrum succinate dehydrogenase inhibitor (SDHI). Penflufen can be used as a fungicide and has broad bioactivity against many fungal diseases, including potato black scurf, wheat sharp eyespot, rice sheath blight, and root rot in peanut and other similar fungal diseases.
    Penflufen
  • HY-N0415R
    Trigonelline chloride (Standard)
    		Inhibitor
    Trigonelline (chloride) (Standard) is the analytical standard of Trigonelline (chloride). This product is intended for research and analytical applications. Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.
    Trigonelline chloride (Standard)
Cat. No. Product Name / Synonyms Application Reactivity