2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16561G
    Resveratrol (GMP)
    		Inhibitor
    Resveratrol (GMP) is Resveratrol (HY-16561) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.
    Resveratrol (GMP)
  • HY-N10905
    Rabdoserrin A
    		Inhibitor
    Rabdoserrin A is a diterpenoid. Rabdoserrin A has antifungal activity.
    Rabdoserrin A
  • HY-P2318
    Bac2A TFA
    		Inhibitor
    Bac2A TFA is an antimicrobial and immunomodulatory peptide. Bac2A TFA is a linear variant of bactenecin and is very effective against fungal pathogens.
    Bac2A TFA
  • HY-P1791
    Lactoferrin (17-41)
    		Inhibitor 98.89%
    Lactoferrin 17-41 (Lactoferricin B), a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 has antitumor activities.
    Lactoferrin (17-41)
  • HY-W582504
    Chlorotris(triphenylphosphine)copper
    		Inhibitor 98.0%
    Chlorotris(triphenylphosphine)copper (CuCl(TPP)₃) is a DNA-targeted metal complex. Chlorotris(triphenylphosphine)copper involves non-covalent interactions (such as groove binding mode) through the copper(I) center to affect DNA function, showing inhibitory activity against bacteria, fungi, and tumor cells. Chlorotris(triphenylphosphine)copper is promising for research of antibacterial, antitumor, and antioxidant agents.
    Chlorotris(triphenylphosphine)copper
  • HY-N8263
    Nepetoidin B
    		Inhibitor
    Nepetoidin B, an anti-inflammatory agent, inhibits inflammation by modulating the NF-κB and Nrf2/HO-1 signaling pathways. Nepetoidin B also has antifungal and antibacterial activity. Nepetoidin B is a natural product that can be obtained from Salvia plebeia R. Br. Nepetoidin B can be used in anti-inflammatory and anti-infectious research.
    Nepetoidin B
  • HY-146116
    Antifungal agent 32
    		Inhibitor
    Antifungal agent 32 (compound 1a) is a potent antifungal agent. Antifungal agent 32 inhibits Candida albicans filamentation and biofilm formation. Antifungal agent 32 inhibits the morphological switching of Candida albicans and its adherence to epithelial cells. Antifungal agent 32 can be used for Candida albicans infections research.
    Antifungal agent 32
  • HY-N0954
    (+)-Pinoresinol diacetate
    		Inhibitor
    (+)-Pinoresinol diacetate is an antifungal agent that can be isolated from Sambucus williamsii.
    (+)-Pinoresinol diacetate
  • HY-125723
    Echinocandin B
    		Inhibitor
    Echinocandin B (A 30912) is an antifungal antibiotic and is the secondary metabolite produced by Aspergillus nidulans.
    Echinocandin B
  • HY-P11021A
    ToAP2 TFA
    		Inhibitor
    ToAP2 TFA is a potent antimicrobial peptide. ToAP2 TFA affects C. albicans membrane permeability and produces changes in fungal cell morphology.
    ToAP2 TFA
  • HY-152896
    Ys-II
    		Inhibitor
    Ys-II (Compound 1) is a spirostanol glycoside that can be isolated from the stem of Yucca elephantipe. Ys-II has antifungal activity against the growth of Candida albicans and Cryptococcus neoformans (IC50: 5 and 6 μg/mL respectively).
    Ys-II
  • HY-N7432R
    DIMBOA (Standard)
    		Inhibitor
    DIMBOA (Standard) is the analytical standard of DIMBOA. This product is intended for research and analytical applications. DIMBOA, an antibiotic, has antibacterial properties and inhibits bacteria such as Staphylococcus aureus and the mycotoxin-producing fungus Fusarium graminearum (which causes scab). DIMBOA exhibits strong free radical scavenging activity and weak iron(III) ion reducing activity, and has antioxidant activity. DIMBOA inhibits the biosynthesis and accumulation of toxic trichothecenes by affecting the expression of Tri6 and Tri5. DIMBOA reduces plant susceptibility to scab. DIMBOA also exhibits cytotoxicity to plant cells, causing plasmolysis, cell collapse, and cell rupture[1][2][3][4][5].
    DIMBOA (Standard)
  • HY-151410
    Chitin synthase inhibitor 5
    		Inhibitor
    Chitin synthase inhibitor 5 (compound 9a) is an inhibitor of chitin synthase with an IC50 value of 0.14 mM. Chitin synthase inhibitor 5 shows broad-spectrum antifungal activity in vitro and shows good inhibition to C. albicans, A. flavus, A. fumigatus and C. neoformans. Chitin synthase inhibitor 5 can be used for the research of fungal.
    Chitin synthase inhibitor 5
  • HY-146023
    Antifungal agent 27
    		Inhibitor
    Antifungal agent 27 (compound 7) is a antifungal agent. Antifungal agent 27 shows moderate antibacterial and weak antifungal activities against MRSA and C. albicans SS5314, with MIC values of 8 and 32 μg/mL, respectively.
    Antifungal agent 27
  • HY-N9695
    2,6-Dihydroxy-4-methoxyacetophenone
    		Inhibitor
    2,6-Dihydroxy-4-methoxyacetophenone is a phytoalexin, that can be isolated from the root tissue of Sanguisorba minor. 2,6-Dihydroxy-4-methoxyacetophenone exhibits antifungal activity. 2,6-Dihydroxy-4-methoxyacetophenone is a strong germination inhibitor on B. cinerea.
    2,6-Dihydroxy-4-methoxyacetophenone
  • HY-125721
    Tetranactin
    		Inhibitor
    Tetranactin is an orally active antibiotic that has insecticidal properties and can inhibit the growth of Gram-positive bacteria and plant pathogenic fungal in vitro. Tetranactin LD50 for intraperitoneal injection in mice is greater than 300 mg/kg, and the LD50 is greater than 15,000 mg/kg.
    Tetranactin
  • HY-169069
    Antifungal agent 110
    		Inhibitor
    Antifungal agent 110 exhibits fungicidal activity toward Botrytis cinerea and Rhizoctonia solani. Antifungal agent 110 displays antifungal activity against R. solani with an EC50 value of 0.27 mg/L. Antifungal agent 110 is promising for research of plant diseases.
    Antifungal agent 110
  • HY-P5701
    EP2
    		Inhibitor
    EP2 is an antimicrobial peptide. EP2 has antibacterial and antifungal activities. EP2 inhibits E. gallinarum, P. pyocyanea, A. baumanii, K. terrigena with a MIC value of 11.4 μg/mL.
    EP2
  • HY-N6625S
    Chlorothalonil-13C2
    		Inhibitor
    Chlorothalonil-13C2 is the 13C-labeled Chlorothalonil. Chlorothalonil is a broad spectrum fungicide and is effective in protecting plants against fungal diseases caused mainly by Phytophthora infestans and Alternaria solani. Chlorothalonil is used for controlling of fungal foliar diseases of vegetables and crops.
    Chlorothalonil-<sup>13</sup>C<sub>2</sub>
  • HY-129515
    Trichodecenin II
    Trichodecenin II is a fungal metabolite that can be found in conidia of the fungus, Trichoderma viride.
    Trichodecenin II
Cat. No. Product Name / Synonyms Application Reactivity