2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-115946
    Complex III-IN-2
    		Inhibitor
    Complex III-IN-2 (Compd 4d-2) is a complex III inhibitor. Complex III-IN-2 shows antifungal activity with an EC50 of 29.98 mg/L and 29.31 mg/L against sclerotinia sclerotiorum and R. solani, respectively.
    Complex III-IN-2
  • HY-115945
    Complex III-IN-1
    		Inhibitor
    Complex III-IN-1 (Compd 4c-2) is a complex III inhibitor. Complex III-IN-1 shows antifungal activity with an EC50 of 18.53 mg/L against sclerotinia sclerotiorum.
    Complex III-IN-1
  • HY-16560R
    Camptothecin (Standard)
    		Inhibitor
    Camptothecin (Standard) (Campathecin (Standard)) is the analytical standard of Camptothecin (HY-16560). This product is intended for research and analytical applications. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells.
    Camptothecin (Standard)
  • HY-158053
    Antifungal agent 94
    		Inhibitor
    Antifungal agent 94 (Compound 49) is a Flavonoid derivative, which exhibits antifungal activity with EC50 of 0.28 μM and a half-maximal effective concentration of 0.46 μg/mL against Rhizoctonia solani.
    Antifungal agent 94
  • HY-B1814
    Vitamin K5
    		Inhibitor
    Vitamin K5 (Synkamin) is a photosensitizer and a antimicrobial agent. Vitamin K5 is a specific PKM2 inhibitor with IC50 values of 28, 191 and 120 μM for PKM2, PKM1 and PKL. Vitamin K5 induces apoptosis of colon 26 cells. Vitamin K5 can be used for the research of infection and cancer, and it also can be used as a preservative for pharmaceuticals, foods, and beverages.
    Vitamin K5
  • HY-141846
    Antifungal agent 17
    		Inhibitor
    Antifungal agent 17 exhibits excellent antifungal properties against B. cinerea with an EC50 value of 2.86 μg/mL.
    Antifungal agent 17
  • HY-N9930
    Effusanin B
    		Inhibitor
    Effusanin B (Compound 3) is a diterpenoid can be isolated from Rabdosia effusa (Maxim.) Hara. Effusanin B (Compound 3) has antifungal activity.
    Effusanin B
  • HY-155127
    Antiproliferative agent-33
    		Inhibitor
    Antiproliferative agent-33 (Compound 2g) is an anti-proliferative, antifungal, and antibacterial agent. Antiproliferative agent-33 inhibits MDA-MB-231 cell proliferation (IC50: 16.38 μM). Antiproliferative agent-33 inhibits gram-negative bacteria growth, and inhibits S. faecalis with an MIC value of 8 μg/mL.
    Antiproliferative agent-33
  • HY-121004
    Bikaverin
    		Inhibitor
    Bikaverin (Lycopersin) is a reddish pigment produced by different fungal species. Bikaverin shows antibiotic properties against certain protozoa and fungi.
    Bikaverin
  • HY-122943
    Moracin D
    		Inhibitor
    Moracin D is a flavonoid that can be isolated from Morus alba. Moracin D induces cell apoptosis and shows hypoglycemic, antiadipogenic, antifungal and antitumor effects. Moracin D can be used for fungal infection and breast cancer research.
    Moracin D
  • HY-114595
    Hemigossypol
    		Inhibitor
    Hemigossypol (Isohemigossypol) is a sesquiterpene natural product that can be isolated from Gossypium barbadense. Hemigossypol has antifungal activity.
    Hemigossypol
  • HY-N6869R
    Dehydroabietic acid (Standard)
    		Inhibitor
    Dehydroabietic acid (Standard) is the analytical standard of Dehydroabietic acid. This product is intended for research and analytical applications. Dehydroabietic acid is a diterpene resin acid that can be isolated from Pinus and Picea. Dehydroabietic acid has anti-bacterial, anti-fungal, anti-inflammatory, and anticancer activities. Dehydroabietic acid is a dual PPAR-α/γ agonist and PPAR-γ partial agonist, which can attenuate insulin resistance (IR) and hepatic steatosis induced by HFD-consumption in mice.
    Dehydroabietic acid (Standard)
  • HY-116214S
    Cyprodinil-d5
    		Inhibitor
    Cyprodinil-d5(CGA-219417-d5) is the deuterium labeled Cyprodinil (HY-116214). Cyprodinil (CGA-219417) is a broad-spectrum anilinopyrimidine fungicide and an activator of the aryl hydrocarbon receptor. Cyprodinil also has anti-androgenic and androgenic activities. Cyprodinil can inhibit the biosynthesis of methionine in plant-pathogenic fungi and protect fruits and vegetables from a variety of pathogens.
    Cyprodinil-d<sub>5</sub>
  • HY-W011303S
    Phytosphingosine-d7
    		Inhibitor
    Phytosphingosine-d7 (4-Hydroxysphinganine-d7) is deuterium labeled Phytosphingosine. Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC50 value of 33.4 μM and can be used in the study of type II diabetes.
    Phytosphingosine-d<sub>7</sub>
  • HY-N7222
    Janthitrem F
    Janthitrem F is a metabolite isolated from tremorigen-producing Penicillium and a potential causative agent of ryegrass spurt disease.
    Janthitrem F
  • HY-P11095
    Pelteobagrin
    		Inhibitor
    Pelteobagrin is a broad-spectrum antimicrobial peptide targeting Gram-positive bacteria, Gram-negative bacteria, and fungi (MIC=2-16 μg/mL). Pelteobagrin exerts bactericidal activity via non-competitive disruption of cell wall and cytoplasmic membrane integrity. Pelteobagrin is promising for research of infectious diseases.
    Pelteobagrin
  • HY-111067
    (4S)-(+)-Ascochin
    		Inhibitor
    (4S)-(+)-Ascochin is an antifungal agent against Microbotryum violaceum, Phytophthora infestans and Septoria tritici. (4S)-(+)-Ascochin also exhibits antialgal activity against Chlorella fusca.
    (4S)-(+)-Ascochin
  • HY-B1263R
    Chlorobutanol (Standard)
    		Inhibitor
    Chlorobutanol (Standard) is the analytical standard of Chlorobutanol. This product is intended for research and analytical applications. Chlorobutanol is a pharmaceutical preservative. Chlorobutanol is active against a wide variety of Gram-positive and Gram-negative bacteria, and several mold spores and fungi. Chlorobutanol is widely used in food and cosmetic industry.
    Chlorobutanol (Standard)
  • HY-17011
    Croconazole
    		Inhibitor 99.24%
    Croconazole is an antifungal agent containing imidazole rings. Croconazole has a unique structural feature of aryl vinyl at the imidazole ring N-1. Croconazole can be used for the identification and quantitative study of major metabolites in rat urine and bile .
    Croconazole
  • HY-178255
    Xanthochymol
    		Inhibitor
    Xanthochymol is an antifungal agent found in Clusia rosea. Xanthochymol can induce fungal apoptosis.
    Xanthochymol
Cat. No. Product Name / Synonyms Application Reactivity