2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B2033S
    Pyrimethanil-13C,15N2
    		Inhibitor
    Pyrimethanil-13C,15N2 is the 13C-labeled and 15N-labeled Pyrimethanil. Pyrimethanil is an?anilinopyrimidine?and broad-spectrum?contact fungicide for the control of Botrytis spp. on a wide variety of crops. Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in?Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection.
    Pyrimethanil-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>
  • HY-P11021
    ToAP2
    		Inhibitor
    ToAP2 is a potent antimicrobial peptide. ToAP2 affects C. albicans membrane permeability and produces changes in fungal cell morphology.
    ToAP2
  • HY-155084
    Antifungal agent 61
    		Inhibitor
    Antifungal agent 61 (Compound 38) is an antifungal agent. Antifungal agent 61 inhibits V. mali with an EC50 value of 0.50 mg/L. Antifungal agent 61 inhibits V. mali by causing cell deformation and contraction, reducing the number of intracellular mitochondria, thickening the cell wall, and increasing the permeability of the cell membrane.
    Antifungal agent 61
  • HY-163688
    Quindecamine acetate
    		Inhibitor
    Quindecamine acetate is a derivative of Quinaldine. Quindecamine acetate has antifungal activity.
    Quindecamine acetate
  • HY-B0364AS
    Dyclonine-d9 hydrochloride
    		Inhibitor
    Dyclonine-d9 (hydrochloride) is deuterium labeled Dyclonine (hydrochloride). Dyclonine hydrochloride (Dyclocaine hydrochloride) is an effective component of Runhou tablets. Dyclonine hydrochloride has significant bactericidal and fungicidal activity.
    Dyclonine-d<sub>9</sub> hydrochloride
  • HY-161375
    SDH-IN-13
    		Inhibitor
    SDH-IN-13 (Compound 5IIIh) is a SDH inhibitor (IC50: 13.7 μg/mL) and an antifungal agent.
    SDH-IN-13
  • HY-113637
    Galbonolide A
    		Inhibitor
    Galbonolide A (Rustmicin) is a potent antifungal agent.Galbonolide A inhibits inositol phosphoceramide synthase. Galbonolide A shows antifungal activity.
    Galbonolide A
  • HY-162500
    Antifungal agent 99
    		Inhibitor
    Antifungal agent 99 (Compound E1) is a fungal succinate dehydrogenase (SDH) inhibitor. Antifungal agent 99 reduces mycelial density and significantly increase the mitochondrial number in mycelia cytoplasm.
    Antifungal agent 99
  • HY-N14363
    Fistupyrone
    		Inhibitor
    Fistupyrone, an antibiotic, is a microbial metabolite found in Streptomyces sp. TP-A0569. Fistupyrone inhibits Alternaria brassicicola infected Chinese cabbage.
    Fistupyrone
  • HY-163353
    Antibacterial agent 193
    		Inhibitor
    Antibacterial agent 193 (Compound 2n) is A monobenzene derivative of spiromarone A, which has antibacterial activity against Rhizoctonia solani. with IC50 value of 5.25 μg/mL.
    Antibacterial agent 193
  • HY-116857R
    Ditalimfos (Standard)
    Ditalimfos (Standard) is the analytical standard of Ditalimfos. This product is intended for research and analytical applications. Ditalimfos is an organophosphate fungicide. Ditalimfos is mainly used in agriculture to control fungal diseases of crops. Ditalimfos can be used for fungal resistance studies and risk assessment of residues in the environment.
    Ditalimfos (Standard)
  • HY-B1878S
    Faltan-d4
    Faltan-d4 is the deuterium labeled Faltan. Faltan is a dicarboximide fungicide, widely used on vines and several vegetable crops, and is also cytotoxic effect on human bronchial epithelial cells.
    Faltan-d<sub>4</sub>
  • HY-N9755
    1-O-Methylemodin
    		Inhibitor
    1-O-Methylemodin is a nature product that could be isolated from Zopfiella longicaudata. 1-O-Methylemodin has antifungal activity.
    1-O-Methylemodin
  • HY-147505
    Antitubercular agent-21
    		Inhibitor
    Antitubercular agent-21 (Compound 15) is an antitubercular agent with an MIC of o.4 µg/mL against M. tuberculosis H37Rv. Antitubercular agent-21 exhibits lower activity against other microorganism such as bacteria gram-positive, gram-negative or fungi. Antitubercular agent-21 shows low cytotoxicity.
    Antitubercular agent-21
  • HY-N0216S2
    Benzoic acid-13C
    		Inhibitor
    Benzoic acid-13C is the 13C-labeled Benzoic acid. Benzoic acid is an aromatic alcohol existing naturally in many plants and is a common additive to food, drinks, cosmetics and other products. It acts as preservatives through inhibiting both bacteria and fungi.
    Benzoic acid-<sup>13</sup>C
  • HY-79131S3
    Fmoc-Phe-OH-15N
    		Inhibitor
    Fmoc-Phe-OH-15N is a 15N-labeled Fmoc-Phe-OH (HY-79131). Fmoc-Phe-OH is a phenylalanine derivative.
    Fmoc-Phe-OH-<sup>15</sup>N
  • HY-126813
    Concanamycin C
    		Inhibitor
    Concanamycin C inhibits proliferation of mouse splenic lymphocytes. Concanamycin C exhibits antibiotic effects against fungal and yeast.
    Concanamycin C
  • HY-B0885R
    Econazole (Standard)
    		Inhibitor
    Econazole (Standard) ((±)-Econazol (Standard)) is the analytical standard of Econazole (HY-B0885). This product is intended for research and analytical applications. Econazole ((±)-Econazol) is an orally active imidazole antifungal agent, as well as a cytochrome P-450 inhibitor and a blocker of calcium and manganese ion uptake. Econazole is active against a variety of fungi and some Gram-positive bacteria, but has no significant activity against Gram-negative bacteria. Econazole can inhibit the synthesis of prostaglandins and can also induce liver damage.
    Econazole (Standard)
  • HY-N10338
    Mildiomycin
    		Inhibitor
    Mildiomycin is a Streptoverticillium rimofaciens antibiotic against powdery mildew of barley. Mildiomycin inhibits some Mycobacterium and Rhodotorula growth, but fails against most fungi and bacteria.
    Mildiomycin
  • HY-151421
    Chitin synthase inhibitor 11
    		Inhibitor
    Chitin synthase inhibitor 11 is a chitin synthase inhibitor. Chitin synthase inhibitor 11 shows excellent chitin synthase inhibitory activity with an IC50 value of 0.10 mM. Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro. Chitin synthase inhibitor 11 can be used for the research of invasive fungal infections (IFIs).
    Chitin synthase inhibitor 11
Cat. No. Product Name / Synonyms Application Reactivity