2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N16430
    Neovasinin
    Neovasinin is a phytotoxin that can be produced by the fungus Neocosmospora vasinfecta. Neovasinin exhibits toxic effects on soybean plants.
    Neovasinin
  • HY-W716464
    Prochloraz-d7
    Prochloraz-d7 (BTS 40542-d7) is the deuterium labeled Prochloraz (HY-B0845). Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC50 of 1 μM.
    Prochloraz-d<sub>7</sub>
  • HY-109125A
    Amcipatricin L-aspartate
    		Inhibitor
    Amcipatricin diaspartate (SPA-S-753) is a semi-synthetic polyene antibiotic, with potent broad-spectrum antifungal activity.
    Amcipatricin L-aspartate
  • HY-121780
    Aranorosin
    		Inhibitor
    Aranorosin, a potent antifungal antibiotic, has been isolated from the culture filtrate and mycelium of a strain of Pseudoarachniotus roseus Kuehn.
    Aranorosin
  • HY-155660
    Antifungal agent 63
    		Inhibitor
    Antifungal agent 63 (Compound 3i) is a fungicidal agent with excellent fungicidal activities against Fusarium oxysporum f.sp. cucumerinum. Antifungal agent 63 can be used for antiviral and fungicidal research.
    Antifungal agent 63
  • HY-P5703
    EP5-1
    		Inhibitor
    EP5-1 is an antimicrobial peptide. EP5-1 has antibacterial and antifungal activities. EP5-1 also shows antitumor activity against cancer cells, and induces cell apoptosis. EP5-1 has antiviral activity against pseudorabies virus (PRV).
    EP5-1
  • HY-107126B
    Ibrexafungerp phosphate
    		Inhibitor
    Ibrexafungerp phosphate is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp phosphate can be used for research of Candida and Aspergillus infections.
    Ibrexafungerp phosphate
  • HY-145437
    N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide
    		Inhibitor
    N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide is a Ole1p desaturase inhibitor and antifungal agent.
    N'-(2-Fluorophenyl)pyrazine-2-carbohydrazide
  • HY-P1934AR
    Cyclo(L-Phe-L-Pro) (Standard)
    		Inhibitor
    Gallic acid (hydrate) (Standard) is the analytical standard of Gallic acid (hydrate). This product is intended for research and analytical applications. Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide. Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation. Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay.
    Cyclo(L-Phe-L-Pro) (Standard)
  • HY-149615
    Antibacterial agent 157
    		Inhibitor
    Antibacterial agent 157 (compound B12) is a fungicidal agent. Antibacterial agent 157 can influence the protein synthesis of Botrytis cinerea. Antibacterial agent 157 can be used for gray mold resistance control research.
    Antibacterial agent 157
  • HY-14603R
    Clioquinol (Standard)
    		Inhibitor
    Clioquinol (Standard) is the analytical standard of Clioquinol. This product is intended for research and analytical applications. Clioquinol (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol acts as an oral antimicrobial agent for the research of diarrhea and skin infections. Antibiotic.
    Clioquinol (Standard)
  • HY-P5569
    SP-B peptide
    		Inhibitor
    SP-B peptide is an antimicrobial peptide. SP-B peptide has antifungal activity against strains of Cryptococcus neoformans, Candida albicans and Aspergillus fumigatus
    SP-B peptide
  • HY-P11125
    Metchnikowin
    		Inhibitor
    Metchnikowin is a fruit fly antimicrobial peptide rich in proline, with dual antibacterial and antifungal activities. Metchnikowin can be independently regulated by TOLL and IMD pathways. Metchnikowin is often used in the research of infectious conditions.
    Metchnikowin
  • HY-151556
    Antifungal agent 45
    		Inhibitor
    Antifungal agent 45 is with fungicidal activities. Antifungal agent 45 shows excellent characteristics superior to Kresoxim-methyl (HY-125776), in which the activity enhancement against Phytophthora capsici was the most remarkable, with an EC50 value of about 5 μM.
    Antifungal agent 45
  • HY-N8512
    Asperfuran
    Asperfuran is an antifungal dihydrobenzofuran derivative produced by a strain of Aspergillus oryzae. Asperfuran weakly inhibits chitin synthase from Coprinus cinereus. Asperfuran shows weak cytotoxicity In HeLa S3 and L1210 cells with an IC50 of 25 μg/ml.
    Asperfuran
  • HY-N12389
    Quellenin
    		Inhibitor
    Quellenin is an anti-saprolegnia compound. Quellenin can be isolated from deep-sea fungus Aspergillus sp. YK-76
    Quellenin
  • HY-P0269A
    Magainin 1 TFA
    		Inhibitor
    Magainin 1 TFA (Magainin I TFA) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 TFA exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria.
    Magainin 1 TFA
  • HY-123135
    Scirpusin B
    		Inhibitor
    Scirpusin B (compound 5) is a dimeric antioxidant isolated from Scirpus maritimus L.. Scirpusin B exhibits antitumor, antifungal, insecticidal, and plant growth inhibitory activities.
    Scirpusin B
  • HY-139669
    Antifungal agent 13
    		Inhibitor
    Antifungal agent 13 exhibits remarkable antifungal activity against Sclerotinia sclerotiorum with an EC50 value of 1.25 mg/L.
    Antifungal agent 13
  • HY-126071
    (-)-Mitorubrinic acid
    (-)-Mitorubrinic acid (Mitorubrinic acid) is a polyketide. (-)-Mitorubrinic acid is synthesis by two non-reducing polyketide synthase (PKS) genes (pks12 and pks11) in a sequential manner. (-)-Mitorubrinic is a virulence factor of Penicillium marneffei by improving its intracellular survival in macrophages.
    (-)-Mitorubrinic acid
Cat. No. Product Name / Synonyms Application Reactivity