2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-117313
    Fumitremorgin B
    		Inhibitor
    Fumitremorgin B is a tremorgenic mycotoxin. Fumitremorgin B exhibits significant antifungal activities, with MICs of 6.25-50 μg/mL.
    Fumitremorgin B
  • HY-P2365
    Histatin-8
    		Inhibitor
    Histatin-8 is a part of the Histatin-3 central sequence and is known as hemagglutination-inhibiting peptide. Histatin-8 is a potent anti-fungal peptide. Histatin-8 shows antimicrobial activity against yeast strains. Histatin-8 can be used for oral thrush research.
    Histatin-8
  • HY-N9768
    (10E,12E)-9-Oxo-10,12-octadecadienoic acid
    		Inhibitor
    (10E,12E)-9-Oxo-10,12-octadecadienoic acid (9-oxo-ODA) is a PPARα agonist that can be isolated from the basidiomycete Gomphus floccosus. (10E,12E)-9-Oxo-10,12-octadecadienoic acid enhances fatty acid oxidation through PPARα activation, thereby inhibiting triglyceride accumulation. (10E,12E)-9-Oxo-10,12-octadecadienoic acid also has antifungal (Fungal) activity.
    (10E,12E)-9-Oxo-10,12-octadecadienoic acid
  • HY-W089856R
    Chlorobutanol hemihydrate (Standard)
    		Inhibitor
    Chlorobutanol (hemihydrate) (Standard) is the analytical standard of Chlorobutanol (hemihydrate). This product is intended for research and analytical applications. Chlorobutanol hemihydrate is a pharmaceutical preservative. Chlorobutanol hemihydrate is active against a wide variety of Gram-positive and Gram-negative bacteria, and several mold spores and fungi. Chlorobutanol hemihydrate is widely used in food and cosmetic industry.
    Chlorobutanol hemihydrate (Standard)
  • HY-B2056
    Triforine
    		Inhibitor
    Triforine (CELA W 524), a systemic fungicide, was shown to display a moderate to distinct fungitoxic activity in vitro towards several pathogenic and non-pathogenic fungi.
    Triforine
  • HY-146107
    Antitubercular agent-23
    		Inhibitor
    Antitubercular agent-23 (Compound 3a) is a potent anticandidiasis and antitubercular agent with MIC values of 1.1 µg/ml and 1 µg/ml against Candida albicans MTCC 3017 and M. tuberculosis (H37Rv), respectively.
    Antitubercular agent-23
  • HY-123177
    Ratjadone
    		Inhibitor
    Ratjadone is a potent antifungal agent. Ratjadone has antifungal activity with MIC values in the range from 0.04 to 0.6 µg/mL for Mucor hiemalis, Phythophthora drechsleri, Ceratocystis ulmi, and Monilia brunnea.
    Ratjadone
  • HY-122451
    Ofurace
    		Inhibitor
    Ofurace is a fungicide that is extremely active against Pythium ultima, Phytophthora tabacum and Phytophthora palmi. Ofurace has a greater effect on sporangia formation than on mycelium growth.
    Ofurace
  • HY-13582A
    Carbendazim hydrochloride
    		Inhibitor
    Carbendazim hydrochloride is a potent and orally active broad-spectrum?benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria,?Fusarium?and?Sclerotina. Carbendazim hydrochloride is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma.
    Carbendazim hydrochloride
  • HY-N10292
    Chaetosemin J
    		Inhibitor
    Chaetosemin J, an antifungal metabolite, exhibits inhibitory activity against plant pathogenic fungi Botrytis cinerea, Alternaria solani, Magnaporthe oryzae, and Gibberella saubinettii, with MIC values ranging from 12.5-25 μM.
    Chaetosemin J
  • HY-157015
    Antifungal agent 81
    		Inhibitor
    Antifungal agent 81(G22)exhibitsexcellent in vitro antifungal activities against Valsa mali withIC50values of 0.48 mg/L. Antifungal agent 81also exhibits excellent in vivo protective againstV. maliat 40 mg/L.
    Antifungal agent 81
  • HY-126740
    Anguinomycin A
    		Inhibitor
    Anguinomycin A is an antibiotic that exhibits good inhibitory activity against G. boninense with an MIC value of 5 µg/disk. Anguinomycin A has antitumor activity.
    Anguinomycin A
  • HY-B0896S1
    Triacetin-d5
    		Inhibitor
    Triacetin-d5 is the deuterium labeled Triacetin. Triacetin is an artificial chemical compound, is the triester of glycerol and acetic acid, and is the second simplest fat after triformin.
    Triacetin-d<sub>5</sub>
  • HY-P4816
    Pseudin-2
    		Inhibitor
    Pseudin-2, an AMP thast could be isolated from the skin of the South American paradoxical frog Pseudis paradoxa, exert a potent growth inhibitory effect against Gram-negative bacteria.
    Pseudin-2
  • HY-156251
    Antifungal agent 74
    		Inhibitor
    Antifungal agent 74 (compound 3c) is a potent antifungal agent that displays excellent fungicidal activity against C. arachidicola and R. solani. Antifungal agent 74 exerts its fungicidal activity by disrupting steroid biosynthesis and ribosome biogenesis in eukaryotes.
    Antifungal agent 74
  • HY-125693
    L685818
    		Inhibitor
    L685818 is a specific immunophilin ligand. L685818 was neuroregenerative and non-neuroprotective in primary brain cultures. L685818 protects dopaminergic neurons from toxic inhibition of MPP+ and 6-OHDA, reduces tyrosine hydroxylase (TH) loss, and promotes neuronal process regeneration. L685818 is also an antifungal reagent for Cryptococcus neoformans.
    L685818
  • HY-W008864
    Lactose octaacetate
    		Inhibitor ≥98.0%
    Lactose octaacetate shows mild to moderate antifungal activity against some fungi, but it has low or no activity against bacteria and yeast. Lactose octaacetate shows low cytotoxicity to MDBK cells, Hep-2 and MDCK cells. Lactose octaacetate has antiviral activity against PV-1.
    Lactose octaacetate
  • HY-124551
    Viridiol
    		Inhibitor
    Viridiol, a fungal metabolite from Trichodernza viride, shows antifungal activity.
    Viridiol
  • HY-16589R
    Oligomycin A (Standard)
    		Inhibitor
    Oligomycin A (Standard) is the analytical standard of Oligomycin A. This product is intended for research and analytical applications. Oligomycin A (MCH 32), created by Streptomyces, acts as a mitochondrial F0F1-ATPase inhibitor, with a Ki of 1 μM; Oligomycin A shows anti-fungal activity.
    Oligomycin A (Standard)
  • HY-149323
    SDH-IN-4
    		Inhibitor
    SDH-IN-4 (compound B6) is a selective inhibitor against succinate dehydrogenase (SDH) with an IC50 value of 0.28 μg/mL. SDH-IN-4 has highly efficient and broad-spectrum antifungal activity, against R. solani with an EC50 value of 0.23 μg/mL.
    SDH-IN-4
Cat. No. Product Name / Synonyms Application Reactivity