2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0852S
    Tebuconazole-d9
    		Inhibitor
    Tebuconazole-d9 is the deuterium labeled Tebuconazole. Tebuconazole is an agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively.
    Tebuconazole-d<sub>9</sub>
  • HY-P0263R
    Dermaseptin (Standard)
    		Inhibitor
    Kanamycin (sulfate) (Standard) is the analytical standard of Kanamycin (sulfate). This product is intended for research and analytical applications. Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia.
    Dermaseptin (Standard)
  • HY-P2292A
    Omiganan, FITC labeled TFA
    		Inhibitor
    Omiganan, FITC labeled TFA is a peptide-FITC complex composed of Omiganan and a FITC. Omiganan is a bactericidal and fungicidal cationic peptide being developed as a topical gel for prevention of catheter-associated infections.
    Omiganan, FITC labeled TFA
  • HY-B0454AS
    Miconazole-d5 nitrate (2,4-Dichlorobenzyloxy-d5)
    		Inhibitor
    Miconazole-d5 (nitrate) (2,4-Dichlorobenzyloxy-d5) is the deuterium labeled Miconazole nitrate. Miconazole nitrate (R18134 nitrate) is an imidazole antifungal agent. Miconazole nitrate also has antibacterial effects.
    Miconazole-d<sub>5</sub> nitrate (2,4-Dichlorobenzyloxy-d5)
  • HY-N5160
    Arborcandin A
    		Inhibitor
    Arborcandin A is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin A exhibits IC50 values of 0.25 μg/mL and 0.05 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin A has an MIC of 4-8 μg/mL against the genus Candida.
    Arborcandin A
  • HY-172804
    SDH-IN-26
    		Inhibitor
    SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor. SDH-IN-26 exhibits significant inhibitory activity against multiple phytopathogenic fungi, such as Rhizoctonia solani and Botrytis cinerea, with an EC50 value of 0.270 μg/mL against Rhizoctonia solani. SDH-IN-26 damages the integrity of the fungal cell membrane, increases membrane permeability, disrupts cell structure, and reduces the number of mitochondria, thus affecting the normal growth of mycelia. SDH-IN-26 leads to a decrease in mitochondrial membrane potential, and induces cell apoptosis. SDH-IN-26 is promising for research of plant diseases caused by fungi.
    SDH-IN-26
  • HY-118448R
    2,4-Diacetylphloroglucinol (Standard)
    2,4-Diacetylphloroglucinol (Standard) is the analytical standard of 2,4-Diacetylphloroglucinol (HY-118448). This product is intended for research and analytical applications. 2,4-Diacetylphloroglucinol is a polyketide antibiotic produced by Pseudomonas fluorescens. 2,4-Diacetylphloroglucinol exhibits broad-spectrum toxicity against various organisms such as bacteria, fungi, oomycetes, and nematodes. 2,4-Diacetylphloroglucinol can also inhibit plant pathogens and affect the root development of tomato seedlings.
    2,4-Diacetylphloroglucinol (Standard)
  • HY-122955
    Xanthobaccin A
    		Inhibitor
    Xanthobaccin A is an antifungal compound, can be isolated from the culture fluid of Stenotrophomonas sp. strain SB-K88. Xanthobaccin A has potent inhibitory effect on sugar beet damping-off disease.
    Xanthobaccin A
  • HY-P5601
    Thanatin
    		Inhibitor
    Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption.
    Thanatin
  • HY-N12513R
    Cyclo(L-Phe-trans-4-OH-L-Pro) (Standard)
    		Inhibitor
    5α-Cholestan-3β-ol (Standard) is the analytical standard of 5α-Cholestan-3β-ol. This product is intended for research and analytical applications. 5α-Cholestan-3β-ol is a derivitized steroid compound.
    Cyclo(L-Phe-trans-4-OH-L-Pro) (Standard)
  • HY-N7123S
    Sulfacetamide-d4
    		Inhibitor
    Sulfacetamide-d4 (Sulphacetamide-d4) is the deuterium labeled Sulfacetamide (HY-N7123). Sulfacetamide (Sulphacetamide) is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide has antifungal and antibacterial activities.
    Sulfacetamide-d<sub>4</sub>
  • HY-132933
    Fungicide4
    		Inhibitor
    Fungicide4 shows the high activity against the P. infestans strain.
    Fungicide4
  • HY-121117
    Chloracetophos
    		Inhibitor
    Derivatives of lucanthone and hycanthone may be mutagenic to germ cells of Drosophila at different stages.
    Chloracetophos
  • HY-B0370S
    Tolnaftate-d7
    		Inhibitor
    Tolnaftate-d7 is the deuterium labeled Tolnaftate. Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent.
    Tolnaftate-d<sub>7</sub>
  • HY-121431
    FR-901235
    FR-901235 is a new type of immunoactive substance produced by an imperfect fungus, Paecilomyces carneus F-4882. FR-901235 partially restored the impaired delayed-type hypersensitivity to sheep red blood cells in tumor-bearing mice.
    FR-901235
  • HY-143405
    Antifungal agent 24
    		Inhibitor
    Antifungal agent 24 (Compound 6) is an antifungal agent against Candida albicans with a MIC value of 0.03 μg/mL.
    Antifungal agent 24
  • HY-146062
    Antibacterial agent 101
    		Inhibitor
    Antibacterial agent 101 (Compd 7f) is an antimicrobial (antibacterial and antifungal) agent, with MIC values between 4 and 32 µg/mL.
    Antibacterial agent 101
  • HY-N10215
    Canadensolide
    		Inhibitor
    Canadensolide is an antifungal metabolite of Penicillium canadense.
    Canadensolide
  • HY-B1790S
    Terconazole-d4
    		Inhibitor ≥99.0%
    Terconazole-d4 is the deuterium labeled Terconazole. Terconazole is a broad-spectrum antifungal medication for the treatment of vaginal yeast infection.
    Terconazole-d<sub>4</sub>
  • HY-N2071R
    Cedrol (Standard)
    		Inhibitor
    Cedrol (Standard) is the analytical standard of Cedrol. This product is intended for research and analytical applications. Cedrol is a potent competitive inhibitor of cytochrome P-450(CYP) enzyme. Cedrol plays an anticancer role by inducing cell cycle arrest and Caspase-dependent apoptosis. Cedrol acts as a neutrophil agonist that can desensitize cells to subsequent stimulation of N-formyl peptides. Cedrol prevents neuropathic pain caused by chronic contractile injury by inhibiting oxidative stress and inflammation. In addition, Cedrol has antibacterial, hair loss prevention and anti-anxiety properties.
    Cedrol (Standard)
Cat. No. Product Name / Synonyms Application Reactivity