2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P2092
    Cyclo(L-leucyl-L-tryptophyl)
    		Inhibitor 99.90%
    Cyclo(L-leucyl-L-tryptophyl) (Cyclo(-Leu-Trp)) is a cyclic dipeptide that inhibits a various of bacteria and fungi. Cyclo(L-leucyl-L-tryptophyl) is a melatonin receptor agonist and is also used as a bitter ligand.
    Cyclo(L-leucyl-L-tryptophyl)
  • HY-107492
    Ethaboxam
    		Inhibitor
    Ethaboxam is a β-tubulin inhibitor that can be used as anti-oomycete fungicide.
    Ethaboxam
  • HY-164620
    Antifungal agent 112
    		Inhibitor 99.50%
    Antifungal agent 112 (Compound 1e) exhibits antifungal activity against Candida albicans, Aspergillus niger and Aspergillus fumigatus with MIC of 0.0024, 0.0022 and 0.0028 M, respectively.
    Antifungal agent 112
  • HY-Y0510
    Nitrofungin
    		Inhibitor 99.82%
    Nitrofungin (2-Chloro-4-nitrophenol) is an antifungal agent, and can also be degraded by some bacteria.
    Nitrofungin
  • HY-B2067R
    Cymoxanil (Standard)
    		Inhibitor
    Cymoxanil (Standard) is the analytical standard of Cymoxanil (HY-B2067). This product is intended for research and analytical applications. Cymoxanil is a fungicidal cyanooxime against plant diseases caused by fungi belonging to the Perenosporales. Cymoxanil affects growth, DNA and RNA synthesis in Phytophthora.
    Cymoxanil (Standard)
  • HY-W473763
    3-Methoxy-2,5-toluquinone
    		Inhibitor 98.01%
    3-Methoxy-2, 5-toluquinone is an antibacterial agent with moderate anti-bacterial and fungal effects.
    3-Methoxy-2,5-toluquinone
  • HY-113219R
    Hydroxyphenyllactic acid (Standard)
    		Inhibitor
    Hydroxyphenyllactic acid (Standard) is the analytical standard of Hydroxyphenyllactic acid. This product is intended for research and analytical applications. Hydroxyphenyllactic acid is an antifungal metabolite.
    Hydroxyphenyllactic acid (Standard)
  • HY-17006S
    Caspofungin-d4 diacetate
    Caspofungin-d4 (acetate) is the deuterium labeled Caspofungin diacetate. Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan.
    Caspofungin-d<sub>4</sub> diacetate
  • HY-151418
    Chitin synthase inhibitor 8
    		Inhibitor
    Chitin synthase inhibitor 8 is a chitin synthase (CHS) inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 8 can be used in the research of fungi infection.
    Chitin synthase inhibitor 8
  • HY-N12343
    Tetrahydrorhombifoline
    		Inhibitor
    Tetrahydrorhombifoline is one of quinolizidine alkaloids in the aerial parts of Genista vuralii A. Duran & H. Dural (Fabaceae). The alkaloid extract of G. vuralii has antibacterial and antifungal activities.
    Tetrahydrorhombifoline
  • HY-W706180
    (±)-Triadimefon-d4
    		Inhibitor 99.47%
    (±)-Triadimefon-d4 is deuterium labeled Triadimefon. Triadimefon is a triazole fungicide used to control powdery mildew, rusts, and other fungal pests on grains, fruit and vegetable crops, turf, shrubs, and trees. Triadimefon inhibits lanosterol 14α-demethylase, interfering with oxidative demethylation reactions in the ergosterol biosynthesis pathway of fungi, and also blocks gibberellin biosynthesis.
    (±)-Triadimefon-d<sub>4</sub>
  • HY-167890
    Flufenoxadiazam
    		Inhibitor
    Flufenoxadiazam is a fungicide. Flufenoxadiazam has potent fungicidal activity, particularly against Phakopsora pachyrhizi and Puccinia triticina.
    Flufenoxadiazam
  • HY-N3344
    Macrocarpal C
    Macrocarpal C can be isolated from the 95 % ethanol extract of fresh leaves of E. globulus. Macrocarpal C inhibits the growth of T. mentagrophytes via an increase in the permeability of the fungal membrane. Macrocarpal C increases the production of intracellular ROS and? induces apoptosis as a consequence of DNA fragmentation.
    Macrocarpal C
  • HY-W210476
    Somantadine
    		Inhibitor 98.58%
    Somantadine (compound I) has potent antimicrobial and antifungal activity.
    Somantadine
  • HY-W160679
    7-(Carboxymethoxy)-4-methylcoumarin
    		Inhibitor 99.42%
    7-(Carboxymethoxy)-4-methylcoumarin (Compound VIIIa) is the antibacterial and antifungal agent that exhibits inhibitory activity against S. aureus, B. cereus, S. lutea, C. albicans, C. glabrata, and C. parapsilosis.
    7-(Carboxymethoxy)-4-methylcoumarin
  • HY-N3706
    Dehydro-α-lapachone
    		98.77%
    Dehydro-α-lapachone can be isolated from the methanol extract of stems of Catalpa ovata G Don. Dehydro-α-lapachone inhibits mycelial growth of Botrytis cinerea with IC50 value 0.41 mg/L.
    Dehydro-α-lapachone
  • HY-40354AR
    Tofacitinib citrate (Standard)
    		Inhibitor
    Tofacitinib (citrate) (Standard) is the analytical standard of Tofacitinib (citrate). This product is intended for research and analytical applications. Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities.
    Tofacitinib citrate (Standard)
  • HY-U00181
    Fludazonium chloride
    		Inhibitor 99.84%
    Fludazonium chloride (R23633) is an anti-fungal agent, which can be used in the treatment and prevention of superficial and systemic fungal infections.
    Fludazonium chloride
  • HY-B1863
    Iprobenfos
    		Inhibitor 99.87%
    Iprobenfos is an organophosphorus fungicide and is widely used to control the rice blast fungus. Iprobenfos can phosphorylate the -OH group on the serine residue in the active (esteratic) site of ChEs and so inhibit both AChE and BChE activity.
    Iprobenfos
  • HY-B1839R
    Fluazinam (Standard)
    		Inhibitor
    Fluazinam (Standard) is the analytical standard of Fluazinam (HY-B1839). This product is intended for research and analytical applications. Fluazinam is a broad spectrum pyridinamine fungal inhibitor. Fluazinam is an orally active dinitroaniline fungicide. Fluazinam induces phosphorylation of JNK, activates p38 pathway, decreases Bcl-2, activates caspase-3, decreases complex I activity, increases Autophagy and Apoptosis. Fluazinam has strong antifungal activity against F. fujikuroi and B. maydis. Fluazinam has a negative impact on Brachydanio rerio and worker bees.
    Fluazinam (Standard)
Cat. No. Product Name / Synonyms Application Reactivity