2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-77995
    2-Methoxybenzaldehyde
    		Inhibitor 99.83%
    2-Methoxybenzaldehyde (o-Anisaldehyde) is a bacterial/fungal inhibitor with a BA50 value of 0.19 for Salmonella. 2-Methoxybenzaldehyde can be used for the study of bacterial and fungal infectious diseases.
    2-Methoxybenzaldehyde
  • HY-17514S1
    Itraconazole-d3
    		99.62%
    Itraconazole-d3 is the deuterium labeled Itraconazole (HY-17514).
    Itraconazole-d<sub>3</sub>
  • HY-P2292
    Omiganan, FITC labeled
    		Inhibitor 98.29%
    Omiganan, FITC labeled is a peptide-FITC complex composed of Omiganan and a FITC. Omiganan is a bactericidal and fungicidal cationic peptide being developed as a topical gel for prevention of catheter-associated infections. FITC is a derivative of fluorescein for the labeling of amines.
    Omiganan, FITC labeled
  • HY-N3557
    Cauloside A
    		Inhibitor 99.55%
    Cauloside A (Leontoside A) is a saponin isolated from Dipsacus asper roots. Cauloside A has potent antifungal activity.
    Cauloside A
  • HY-32291
    Methyl L-pyroglutamate
    		Inhibitor 99.62%
    Methyl L-pyroglutamate ((S)-Methyl 5-oxopyrrolidine-2-carboxylate;L-Pyroglutamic acid methyl ester) is isolated from P. oleracea and has anti-inflammatory activity.
    Methyl L-pyroglutamate
  • HY-126562
    Piperlonguminine
    		Inhibitor 99.31%
    Piperlonguminine is an alkaloid amide isolated from the Piper species. Piperlonguminine shows various biological properties, including anti-inflammatory, antitumor, neuroprotective, anti-platelet, anti-melanogenic, antifungal and antibacterial activities.
    Piperlonguminine
  • HY-N4203
    Isopropyl ferulate
    		99.97%
    Isopropyl ferulate, isolated from Notopterygium incisum, is used in the reduction of pharmaceuticals, preparation of antifungal agents, cosmetics and as antioxidant agent and so forth.
    Isopropyl ferulate
  • HY-17373R
    Posaconazole (Standard)
    		Inhibitor
    Posaconazole (Standard) is the analytical standard of Posaconazole. This product is intended for research and analytical applications. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
    Posaconazole (Standard)
  • HY-16779
    Fosravuconazole
    		Inhibitor 99.86%
    Fosravuconazole (BMS-379224), a proagent of Ravuconazole, is an orally active broad spectrum antifungal agent. Fosravuconazole can be used for candidiasis, onychomycosis and parasitemia research.
    Fosravuconazole
  • HY-N4116
    Xanthyletin
    		Inhibitor 98.58%
    Xanthyletin is a coumarin isolated from Stauranthus perforatus, with anti-tumor and anti-bacterial activities. Xanthyletin also inhibits symbiotic fungus cultivated by leaf-cutting ants.
    Xanthyletin
  • HY-B0843
    Metalaxyl
    		Inhibitor 98.21%
    Metalaxyl is a fungicide agent that inhibits the protein synthesis in fungi. Metalaxyl against downy mildews and soil-borne diseases by Phytium ssp. and Phytophthora ssp..
    Metalaxyl
  • HY-126779
    Stictic acid
    		98.5%
    Stictic acid is a secondary metabolite that can be isolated from the lichen Lobaria pulmonaria (L.) Hoffm. Stictic acid inhibits growth of human colon adenocarcinoma HT-29 cells (IC50: 29.29 μg/mL).
    Stictic acid
  • HY-136355
    Picoxystrobin
    		Inhibitor 99.76%
    Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity.
    Picoxystrobin
  • HY-P0263A
    Dermaseptin TFA
    		Inhibitor 99.21%
    Dermaseptin TFA, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration.
    Dermaseptin TFA
  • HY-N8139
    2-Amino-3-carboxy-1,4-naphthoquinone
    		99.59%
    2-Amino-3-carboxy-1,4-naphthoquinone is the electron transfer mediator. 2-Amino-3-carboxy-1,4-naphthoquinone changes glucose metabolism of the homofermentative lactic acid bacteria.
    2-Amino-3-carboxy-1,4-naphthoquinone
  • HY-N9357
    Granilin
    		Inhibitor 99.60%
    Granilin, a sesquiterpene lactone, can be found in the flower buds of Carpesium triste. Granilin can be used as the bactericide and fungicide.
    Granilin
  • HY-N8015S
    Octanal-d16
    		Inhibitor
    Octanal-d16 is the deuterium labeled Octanal. Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC50 value of 3.5 μg/mL.
    Octanal-d<sub>16</sub>
  • HY-N4181
    Kanzonol C
    		Inhibitor
    Kanzonol C, a flavonoid isolated from the twigs of Dorstenia barteri (Moraceae), has potential to treat bacterial and fungal infections.
    Kanzonol C
  • HY-126114
    Lupeol acetate
    		Inhibitor ≥98.0%
    Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility.
    Lupeol acetate
  • HY-120734
    Quinoxyfen
    		Inhibitor ≥98.0%
    Quinoxyfen (DE-795) is a powdery mildew fungicide.
    Quinoxyfen
Cat. No. Product Name / Synonyms Application Reactivity