2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0359
    Fenticonazole Nitrate
    		Inhibitor 98.92%
    Fenticonazole Nitrate is an antifungal imidazole ring derivative. Fenticonazole Nitrate operates via hindering ergosterol integration, and sequentially destructing the cytoplasmatic outer membrane. Fenticonazole Nitrate is effective against Gram-positive bacteria, mycoses, and vaginal candidiasis.
    Fenticonazole Nitrate
  • HY-W041080
    3,5-Di-tert-butylphenol
    		Inhibitor 99.98%
    3,5-Di-tert-butylphenol is an volatile organic compound with anti-biofilm and antifungal activities. 3,5-Di-tert-butylphenol induces accumulation of reactive oxygen species (ROS) in C. albicans cells. 3,5-Di-tert-butylphenol also has antibacterial activities.
    3,5-Di-tert-butylphenol
  • HY-W007355S
    Skatole-d3
    		Inhibitor ≥98.0%
    Skatole-d3 is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
    Skatole-d<sub>3</sub>
  • HY-N6656
    6-Hydroxycoumarin
    		99.32%
    6-Hydroxycoumarin is a coumarin which has anti-inflammatory, anti-pyretic, anti-oxidant, vasodilator, anti-amoebic, anti-bacterial, anti-fungal, bacteriostatic and antitumor activity.
    6-Hydroxycoumarin
  • HY-B1151
    Climbazole
    		Inhibitor 98.26%
    Climbazole (BAY-e 6975) is a potent antifungal agent. Climbazole also is a potent inducer of rat hepatic cytochrome P450.
    Climbazole
  • HY-143899
    FBA-IN-1
    		Inhibitor 98.79%
    FBA-IN-1 (compound 2a11) is a first-in-class, covalent and allosteric inhibitor of fructose-1,6-bisphosphate aldolase from Candida albicans (CaFBA). FBA-IN-1 inhibits the growth of Azole-resistant strains 103 with the MIC80 of 1 μg/mL.
    FBA-IN-1
  • HY-N1448
    Vincetoxicoside B
    		Inhibitor 99.90%
    Vincetoxicoside B shows antifungal activity.
    Vincetoxicoside B
  • HY-W020182
    α-Terpinene
    		Inhibitor
    α-Terpinene (Terpilene) is a monoterpene found in the essential oils of a large variety of foods and aromatic plants such as Mentha piperita. α-Terpinene is active against Trypanosoma evansi and has the potential for trypanosomosis treatment. α-Terpinene has antioxidant and antifungal properties.
    α-Terpinene
  • HY-B0914
    10-Undecenoic acid,98% (stabilized with TBC)
    		Inhibitor ≥98.0%
    10-Undecenoic acid (Undecylenic acid) is an antifungal agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa.
    10-Undecenoic acid,98% (stabilized with TBC)
  • HY-121935
    Tecnazene
    		Inhibitor 99.96%
    Tecnazene (2,3,5,6-Tetrachloronitrobenzene) is a fungicide and is used as a sprout inhibitor on stored potatoes.
    Tecnazene
  • HY-117766
    PC945
    		Inhibitor 99.27%
    PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. PC945 is also a potent, tightly binding inhibitor of A. fumigatus sterol 14α-demethylase activity, CYP51A and CYP51B, with IC50s of 0.23 μM and 0.22 μM, respectively.
    PC945
  • HY-106541
    Neticonazole
    		Inhibitor 99.58%
    Neticonazole is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole has anti-infection and anti-cancer effects.
    Neticonazole
  • HY-128365
    Neticonazole hydrochloride
    		Inhibitor 99.96%
    Neticonazole hydrochloride is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole hydrochloride has anti-infection and anti-cancer effects.
    Neticonazole hydrochloride
  • HY-147110
    APX2039
    		Inhibitor 98.44%
    APX2039 is an orally active and potent inhibitor of the fungal Gwt1 enzyme. APX2039 has extremely potent anticryptococcal activity against C. neoformans and C. gattii. APX2039 blocks the localization of GPI (glycosylphosphatidyl inositol)-anchored cell wall mannoproteins. APX2039 can be used for Cryptococcal meningitis (CM) research.
    APX2039
  • HY-W010520
    Methylisothiazolinone
    		Inhibitor 99.37%
    Methylothiazolinone is a bacterial and fungal inhibitor and preservative, as well as a sensitizer. Methylisothiazolinone can activate matrix metalloproteinases (MMPs) in human bronchial epithelial cells to induce apoptosis and inflammatory response. Methylisothiazolinone can promote the development of atopic dermatitis in mice by disrupting Th2/Th17 related immune responses. Methylisothiazolinone can cause mitochondrial damage in the endothelium of rat cerebral blood vessels.
    Methylisothiazolinone
  • HY-138540
    1-Dodecylimidazole
    		Inhibitor 99.78%
    1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity.
    1-Dodecylimidazole
  • HY-W010435
    Sulcatone
    		Inhibitor 99.80%
    Sulcatone (6-Methyl-5-hepten-2-one) is a plant-derived volatile organic compound with activities such as insecticidal, antifungal, and blood pressure-lowering effects. Sulcatone also serves as an insect pheromone and an endogenous metabolite, which can be found in feces. Changes in Sulcatone levels can be used for the auxiliary diagnosis of ulcerative colitis.
    Sulcatone
  • HY-130703
    5-Dehydroepisterol
    		Inhibitor
    5-Dehydroepisterol is an episterol derivative and an intermediate in steroid biosynthesis. 5-Dehydroepisterol can be formed by C-5 sterol desaturase and converted into 24-methylenecholesterol by 7-dehydrocholesterol reductase. 5-Dehydroepisterol has anti-fungal activities.
    5-Dehydroepisterol
  • HY-14273S
    Isavuconazole-d4
    		Inhibitor 99.88%
    Isavuconazole-d4 is a deuterium labeled Isavuconazole (BAL-4815). Isavuconazole is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi.
    Isavuconazole-d<sub>4</sub>
  • HY-106542A
    Eberconazole nitrate
    		99.76%
    Eberconazole nitrate is a dichlorinated imidazole derivative with antifungal activity. Eberconazole nitrate is more effective than Clotrimazole (HY-10882), Ketoconazole (HY-B0105), and Miconazole (HY-B0454). Eberconazole nitrate has potential for the study of dermatophytosis.
    Eberconazole nitrate
Cat. No. Product Name / Synonyms Application Reactivity