FXR

FXR; NR1H4

FXR

Related Products

Farnesoid X receptor (FXR) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily. FXR regulates the expression of various genes by binding to DNA either as a monomer or a heterodimer with the common partner for NRs, retinoid x receptor (RXR), to FXR response elements. Two known FXR genes exist, the FXRα and FXRβ.

FXR is mainly expressed in liver and small intestine, where it plays an important role in bile acid, lipid, and glucose metabolism. FXR affects several metabolic pathways through its specific target genes, regulating bile acid (BA) synthesis and homeostasis, glucose and lipid metabolism, also exhibiting a crucial role in intestinal bacterial growth and liver regeneration.

FXR Related Products (126)
Antibodies (2)

By Effects:	Control (1) Inhibitors (10) Agonists (61) Antagonists (26) Activators (17) Modulators (5)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N3891

Fargesone A	Agonist
Fargesone A is a potent and selective FXR agonist. Fargesone A shows anti-inflammatory activity.

HY-169792

HPG1860	Agonist
HPG1860 is an orally active, highly selective and potent FXR agonist, with an EC₅₀ of 18 nM (FXR-luciferase reporter assay). HPG1860 has EC₅₀ values >30.0 μM for TGR5 and 13 other related nuclear receptors (cAMP biological assay). HPG1860 can be used for the research of non-alcoholic steatohepatitis (NASH).

HY-163466

FXR agonist 7	Inhibitor
FXR agonist 7 (compound 33) is a potent agonist of FXR, with EC₅₀ of 0.1 nM. FXR agonist 7 shows high intestinal distribution, good anti-inflammatory activity.

HY-168332

FXR agonist 11	Agonist
FXR agonist 11 (Compound 14) is an FXR agonist with an EC₅₀ of 1.2 μM and a maximum effect of 73.7%. FXR agonist 11 can significantly increase GSH levels in the liver and is used to study drug-induced liver injury diseases.

HY-W653920

Tauro 6-ethlchenodeoxycholic acid-d₅(sodium）	Agonist
Tauro 6-ethlchenodeoxycholic acid-d₅ sodium is deuterium labeled Tauro-obeticholic acid (HY-135399). Tauro-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an orally bioavailable farnesoid-X receptor (FXR) agonist.

HY-50108A

(E)-GW 4064	Agonist
(E)-GW 4064 is a FXR agonist.

HY-122338

Fexarine	Agonist
Fexarine is a potent, non-steroidal and selective agonist of farnesoid X receptor (EC₅₀: 38 nM). Fexarine can be used for the research of diseases linked to cholesterol, bile acids.

HY-168516

FXR/CES2 modulator 1	Inhibitor
FXR/CES2 modulator 1 (compound LE-77) is a doul modulator that activates FXR and inhibits CES2. FXR/CES2 modulator 1 effectively mitigates the intestinal toxicity of irinotecan.

HY-N11081

Hexanorcucurbitacin D	Agonist
Hexanorcucurbitacin D, a cucurbitacin, is a weak ecdysteroid receptor agonist. Hexanorcucurbitacin D can be isolated from Trichosanthes cucumeroides roots. Hexanorcucurbitacin D can be used for the research of cardiovascular disease (CVD).

HY-160929

Linafexor	Agonist
Linafexor (CS-0159) is an agonist for farnesoid X receptor (FXR).

HY-W712932

Chenodeoxycholic Acid-d₇
Chenodeoxycholic Acid-d₇ (CDCA-d₇) is the deuterium labeled Chenodeoxycholic Acid (HY-76847). Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.

HY-169192

BAR-2227	Agonist
BAR-2227 (compound 3a) is a FXR agonist and LIFR inhibitor. BAR-2227 can be used to study liver fibrosis and inflammation.

HY-N3209

Nelumol A	Agonist
Nelumol A is a farnesoid X receptor (FXR) agonist.

HY-W713010

3-Epideoxycholic acid-d₅
3-Epideoxycholic acid-d₅ is the deuterium labeled 3-Epideoxycholic acid (HY-48814). 3-Epideoxycholic acid is the microbial metabolite of Deoxycholic acid (HY-N0593). 3-Epideoxycholic acid targets FXR of dendritic cells, reduces their immunostimulatory properties, promotes the generation of Treg cells, and exhibits anti-inflammatory activity. 3-Epideoxycholic acid promotes the growth of bacteria Bacteroides.

HY-135400S

Glyco-obeticholic acid-d₅	Agonist
Glyco-obeticholic acid-d₅ is the deuterium labeled Glyco-Obeticholic acid. Glyco-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is a farnesoid X receptor (FXR) agonist.

HY-121110

Fexarene	Agonist
Fexarene is a potent and selective nonsteroidal Farnesoid X Receptor (FXR) agonist with an EC₅₀ of 36 nM. Fexarene can be used in studies of cholesterol and bile acid metabolism.

HY-133890

Tauro-α-muricholic acid	Activator
Tauro-alpha-muricholic acid (T-alpha-MCA) is a bile acid that belongs to a class of compounds that are synthesized in the liver and play an important role in the digestive process. Tauro-α-muricholic acid activates Farni X receptors (FXR) which are involved in the regulation of bile acid synthesis, metabolism and transport. Tauro-alpha-muricholic acid can be used in the study of metabolic syndrome and cardiovascular disease.

HY-168327

LH10	Agonist
LH10 is a fexaramine-based agonist for FXR with an EC₅₀ of 0.14 μM. LH10 exhibits liver protection efficacy, ameliorates the alpha naphthylisothiocyanate (ANIT)-induced cholestasis, APAP (HY-66005)-induced acute liver injury and non-alcoholic steatohepatitis (NASH) in mouse models.

HY-159845

Lecufexor	Agonist
Lecufexor is a farnesoid X receptor (FXR) agonist.

HY-135399S

Tauro-obeticholic acid-d₅ sodium	Agonist
Tauro-obeticholic acid-d₅ sodium is deuterium labeled Tauro-obeticholic acid. Tauro-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an orally bioavailable farnesoid-X receptor (FXR) agonist.

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FXR

FXR

FXR Related Products (126)

Antibodies (2)

FXR Related Products (126):