Dynamin Inhibitor

Dynamin Inhibitors (37):

Cat. No.	Product Name	Effect	Purity

HY-15886

Mdivi-1	Inhibitor	99.96%
Mdivi-1 is a selective dynamin-related protein 1 (Drp1) inhibitor. Mdivi-1 is a mitochondrial division/mitophagy inhibitor.

HY-15304

Dynasore	Inhibitor	99.66%
Dynasore is a cell-permeable dynamin inhibitor with an IC₅₀ of 15 μM. Dynasore blocks cell migration.

HY-13863

Hydroxy-Dynasore	Inhibitor	99.11%
Hydroxy Dynasore (Dyngo-4a), a structural mimetic analog of Dynasore (HY-15304), is an improved, less cytotoxic and versatile dynamin inhibitor with IC₅₀ values of 0.38 μM and 2.3 μM for brain recombinant dynamin I and recombinant mouse dynamin II, respectively. Hydroxy Dynasore inhibits dynamin-dependent transferrin endocytosis with an IC₅₀ of 5.7 μM.

HY-N0703

Schaftoside	Inhibitor	99.57%
Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission.

HY-131683

ES9-17	Inhibitor	99.87%
ES9-17 is an analog of ES9 (endosidin9), which is an inhibitor of clathrin heavy chain (CHC). ES9-17 is an inhibitor of clathrin-mediated endocytosis (CME), a major route for internalization of plasma membrane proteins and molecules from the extracellular environment in plants. ES9-17 inhibits the uptake of transferrin and FM4-64. ES9-17 also inhibits root growth of Arabidopsis seedings.

HY-172531

Sulfonadyn-47	Inhibitor
Sulfonadyn-47 is a GTP-competitive dynamin I (dynI) inhibitor that targets the active site in the GTPase domain of dynamin I, with IC₅₀ values of 3.5 μM against dynI, 27.3 μM in clathrin-mediated endocytosis (CME) assays, and 12.3 μM in synaptic vesicle endocytosis (SVE) assays. Sulfonadyn-47 increases seizure threshold. Sulfonadyn-47 can be used the study for the seizure.

HY-P11005

P259	Inhibitor
P259 is a Drp1-Mff inhibitor. P259 distinguishes physiological from pathological fission by specifically inhibiting Drp1-Mff interaction. P259 elongates cell mitochondria and disrupts mitochondrial function and motility. P259 reduces ATP levels and alters mitochondrial structure in the brain, resulting in behavioral deficits in wild-type mice and a short lifespan in Huntington's disease (HD) mice model.

HY-107545

Dynole 34-2	Inhibitor	99.25%
Dynole 34-2 is a potent dynamin GTPase inhibitor (IC₅₀s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME).

HY-P10368

P110 heptapeptide	Inhibitor	99.84%
P110 heptapeptide is a peptide inhibitor of the Drp1-Fis1 interaction. P110 heptapeptide has anti-inflammatory, immunomodulatory, mitochondrial protective, and neuroprotective activities. Without blocking the physiological functions of Drp1, P110 heptapeptide reduces pathological functions in many models of neurodegeneration, ischemia, and sepsis. P110 heptapeptide can be used for research on neurological and inflammatory diseases.

HY-145080

Dynole 2−24	Inhibitor	98.13%
Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC₅₀=0.56 μM for dynamin I). Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC_₅₀(CME)=1.9 μM). Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis. CME: Clathrin mediated endocytosis

HY-161119

Drpitor1a	Inhibitor
Drpitor1a is a potent Drp1 inhibitor. Drpitor1a inhibits mitochondrial ROS production, preventes mitochondrial fission, and improves right ventricular diastolic dysfunction during IR (ischemia reperfusion) injury. Drpitor1a has the potential for the research of lung cancer^[1]

HY-P2280

TAT-P110	Inhibitor	99.87%
TAT-P110, a peptide inhibitor of Drp1-Fis1 interaction, reduces pathology in numerous models of neurodegeneration, ischemia, and sepsis without blocking the physiological functions of Drp1.

HY-152218

Clathrin-IN-4	Inhibitor	99.54%
Clathrin-IN-4 (compound 8b), a Wiskostatin (HY-12534) analogue, is a potent inhibitor of clathrin mediated endocytosis with an IC₅₀ of 2.1 μM. Clathrin-IN-4 is a dynamin I GTPase activity inhibitor with an IC₅₀ of 9.1 μM.

HY-131873

Dynapyrazole-A	Inhibitor	98.41%
Dynapyrazole A is a specific inhibitor of microtubule dynamin that specifically inhibits the ATPase activity of microtubule-stimulated dynamin without blocking microtubule-independent basal activity.

HY-155656

Anti-inflammatory agent 49	Inhibitor	98.26%
nti-inflammatory agent 49 (compound SC9) is a quite potent and selective inhibitor of Drp1-Fis1 interaction and can reduce FIS1-mediated mitochondrial dysfunction. The IC₅₀ of SC9 inhibiting GTPase in vitro is 270 nM.

HY-152215

Dynamin IN-1	Inhibitor	99.89%
Dynamin IN-1 is a potent dynamin inhibitor with an IC₅₀ value of 1.0 µM.

HY-164566

POSH-IN-2	Inhibitor	99.65%
POSH-IN-2 (MIDI), a mitochondrial division inhibitor, is a DRP1 inhibitor that potently blocks mitochondrial fragmentation induced by cellular stresses and genetic mitochondrial lesions. POSH-IN-2 covalently interacts with DRP1-C367 to target DRP1 interaction with multiple receptors.

HY-125222

Drp1-IN-1	Inhibitor	98.02%
Drp1-IN-1 (comp A-7) is a dynamin-1-like protein (Drp1) inhibitor, with an IC₅₀ of 0.91 μM.

HY-P1369

DynaMin inhibitory peptide, myristoylated	Inhibitor	99.81%
DynaMin inhibitory peptide, myristoylated is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated is a membrane-permeant form of the peptide that prevents endocytosis.

HY-W013158

Trimethyloctadecylammonium bromide	Inhibitor	≥98.0%
Trimethyloctadecylammonium bromide is an inhibitor of dynamin, with an IC₅₀ value of 1.9 μM for dynamin I. Trimethyloctadecylammonium bromide exhibits antibacterial activity against Staphylococcus aureus.

Name
Email *

	Sorry, but the email address you supplied was invalid.