Cannabinoid Receptor

Cannabinoid Receptor Related Products (267):

By Effects:	Inhibitors (18) Controls (2) Ligands (7) Agonists (51) Antagonists (38) Activators (10) Modulators (14) Chemical (1)

Cat. No.	Product Name	Effect	Purity

HY-15443

AM251	Antagonist	99.09%
AM251 is a selective cannabinoid 1 (CB1) receptor antagonist with an IC₅₀ of 8 nM. AM251 also acts as a potent GPR55 agonist with an EC₅₀ of 39 nM.

HY-110004

ACEA	Agonist
ACEA (short for arachidonyl-2'-chloroacetamide) is a synthetic organic compound that acts as an agonist of the cannabinoid receptor CB1. It is a chemical that affects the endocannabinoid system in the body, which regulates various physiological processes such as appetite, pain perception, mood, and memory.

HY-153800

Monlunabant	Antagonist	99.97%
Monlunabant ((S)-MRI-1891) is an orally active antagonist for cannabinoid receptor 1 (CB1), binds to hCB1 and hCB2 with K_i of 0.3 nM and 613 nM.

HY-10013

Taranabant	Inhibitor	99.14%
Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist that inhibits the binding and functional activity of various agonists, with a binding K_i of 0.13 nM for the human CB1R in vitro.

HY-B1161A

S-Methoprene	Antagonist	98.58%
S-Methoprene is an insect juvenile hormone analog and effective insecticide that blocks the transition from pupa to adult. S-Methoprene is also a CB(1) receptor ligand and inhibits the binding of the CB1 receptor antagonist [³H]CP-55940 to the CB1 receptor (IC₅₀: 19.31 μM).

HY-113591

CB2 receptor agonist 10	Activator	≥99.0%
CB2 receptor agonist 10 is a CB2 receptor agonist with a K_i of 3.7 nM for hCB2, a K_i of 110 nM for hCB1, and an EC₅₀ of 0.52 nM for hCB2.

HY-172587

CB1R Allosteric modulator 5	Modulator
CB1R Allosteric modulator 5 (compound 3) is a selective, and blood-brain barrier (BBB) permeable Cannabinoid receptor type 1 allosteric modulator with a pIC₅₀ of 6.89. CB1R Allosteric modulator 5 attenuates both cocaine-seeking behavior specific to cue-induced reinstatement and cocaine-induced behavioral sensitization without altering locomotor activity.

HY-W775306

Cannabidivarinic acid	Ligand	99.67%
Cannabidivarinic acid (CBDVA), the carboxylic acid precursor of Cannabidivarin(CBDV), is a non-psychoactive cannabinoid found in Cannabis with anti-inflammatory properties.

HY-159115

ART26.12	Activator	99.57%
ART26.12 is a potent, selective and orally active inhibitor of FABP5. ART26.12 can regulate lipid metabolism and activate cannabinoid receptors. ART26.12 has analgesic effects and can be used in the research of diseases such as peripheral neuropathy and psoriasis.

HY-16642A

LY2828360	Agonist	99.50%
LY2828360 is a slowly acting but efficacious G protein-biased cannabinoid (CB₂) agonist, inhibiting cAMP accumulation and activating ERK1/2 signaling.

HY-111110

Olorinab	Agonist	99.29%
Olorinab (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB₂) agonist, with an EC₅₀ of 6.2 nM for hCB₂.

HY-156831

Lixosicone	Antagonist	99.39%
Lixosicone is a signaling-specific inhibitor of the cannabinoid receptor 1 (CB1-SSi). Lixosicone plays an important role in Cannabis use disorder (CUD).

HY-148137

CB1 agonist 1	Agonist	99.84%
CB1 agonist 1 (compound 22) is an agonist of CB1. CB1 agonist 1 shows affinity to CB1 receptor with an pIC₅₀ value of 5.7. CB1 agonist 1 can be used for the research of brain disorders.

HY-103335

O1918	Antagonist
O1918 is a selective non-CB₁ receptor and GPR18 antagonist.

HY-130311

2-Linoleoyl glycerol	Inhibitor
2-Linoleoyl glycerol (2-Monolinolein; 2-Monolinoleoylglycerol) is a monoacylglycerol that is an antagonist and partial agonist at the type 1 cannabinoid CB1 receptor. The potency of 2-Linoleoyl glycerol can be enhanced by JZL195 (HY-15250), an inhibitor of FAAH and MAGL, and inhibited by the CB1 antagonist AM251 (HY-15443) and Cannabidiol. As a CB1 antagonist, 2-Linoleoyl glycerol does not enhance, but only attenuates, the activity of the CB1/CB2 receptor ligands cannabinoids (AEA) and 2-arachidonoylglycerol (2-AG).

HY-14791A

(±)-Ibipinabant	Antagonist	99.30%
(±)-Ibipinabant ((±)-SLV319) is the racemate of SLV319. (±)-Ibipinabant ((±)-SLV319) is a potent and selective cannabinoid-1 (CB-1) receptor antagonist with an IC₅₀ of 22 nM.

HY-116418

Virodhamine	Modulator	≥98.0%
Virodhamine is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine induces megakaryocytic differentiation by triggering MAPK signaling and ROS production. Virodhamine can be used for the research of various neurological disorders such as Alzheimer's and Parkinson's diseases.

HY-110206

AM6545	Antagonist	99.32%
AM6545 is a highly selective, brain-free (peripherally active) CB1 receptor antagonist (K_i=1.7 nM). AM6545 inhibits endocannabinoid signaling by competitively antagonizing CB1 receptors, inhibiting CB1-mediated appetite stimulation and inflammatory responses without affecting cAMP levels. AM6545 significantly reduces food intake and body weight in mice, while improving metabolic syndrome-related renal impairment (such as proteinuria, fibrosis) and insulin resistance. AM6545 can be used in the study of obesity and its complications.

HY-110036A

GW405833 hydrochloride	Agonist	99.59%
GW-405833 (L768242) hydrochloride is a potent, selective cannabinoid receptor 2 (CB₂) agonist with an EC₅₀ of 50.7 nM. GW-405833 hydrochloride also behaves as a noncompetitive CB₁ antagonist. GW-405833 hydrochloride suppresses inflammatory and neuropathic pain.

HY-10871

Otenabant	Antagonist	99.23%
Otenabant is a potent and selective cannabinoid receptor CB1 antagonist with K_i of 0.7 nM, exhibits 10,000-fold greater selectivity against human CB2 receptor.

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