2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel

Calcium Channel

Ca2+ channels; Ca channels

Calcium Channel

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Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W278072
    Calcium Channel antagonist 1
    		Antagonist
    Calcium Channel antagonist 1 is an antagonist of Calcium Channel Calcium Channel antagonist 1 has the potential for the research of neurology disease.
    Calcium Channel antagonist 1
  • HY-17436S3
    (R)-Clevidipine-13C,d3
    (R)-Clevidipine-13C,d3 is the deuterium and 13C labeled Clevidipine. Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension.
    (R)-Clevidipine-<sup>13</sup>C,d<sub>3</sub>
  • HY-B0473R
    Tetracaine (hydrochloride) (Standard)
    		Inhibitor
    Tetracaine (hydrochloride) (Standard) is the analytical standard of Tetracaine (hydrochloride). This product is intended for research and analytical applications. Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic.
    Tetracaine (hydrochloride) (Standard)
  • HY-P5954
    PLTX-II
    		Inhibitor
    PLTX-II is a calcium channel blocker. PLTX-II has a 44-residue peptide containing ten Cys residues and an O-palmitoylated threonine amide at the carboxy-terminus.
    PLTX-II
  • HY-16489
    Terodiline
    		Antagonist
    Terodiline, an antispasmodic agent, blocks hERG current with the IC50 of 375 nM. Terodiline has both anticholinergic and calcium antagonist properties, and effectively reduces abnormal bladder contractions caused by detrusor instability. Terodiline can be used for the research of urinary incontinence.
    Terodiline
  • HY-106832
    Vatanidipine
    		Antagonist
    Vatanidipine (Watanidipine) is an orally active dihydropyridine (DHP)-type calcium channel blocker and a useful antihypertensive agent. Vatanidipine shows vasodilatory effects and also suppresses noradrenaline release from sympathetic nerve endings.
    Vatanidipine
  • HY-154832
    Cav 3.2 inhibitor 4
    		Inhibitor
    Cav 3.2 inhibitor 4 (compound 21) is a potent, peripherally restricted, selective T-type calcium channel (Cav3.2) inhibitor, with an IC50 of 0.6 μM. Cav 3.2 inhibitor 4 can be used for the research of atrial fibrillation.
    Cav 3.2 inhibitor 4
  • HY-135228
    GZ4
    GZ4 is a calcium current inhibitor with direct inhibitory activity on cell surface channels. GZ4 inhibition reverses mechanical hyperalgesia/hyperalgesia in a spinal nerve ligation-induced neuropathic pain model. The mechanism of action of GZ4 is similar to that of gabapentin, but the time course of its biological effects is more rapid, indicating that GZ4 can directly inhibit calcium channel currents.
    GZ4
  • HY-P6013
    wt hMLN
    		Inhibitor
    wt hMLN is a microprotein that inhibits of SR Ca2+ pump (SERCA). wt hMLN plays an important role in skeletal muscle calcium homeostasis.
    wt hMLN
  • HY-B0612AS1
    Lercanidipine-13C,d3-1 hydrochloride
    		Inhibitor
    Lercanidipine-13C,d3-1 (hydrochloride) is deuterium labeled Lercanidipine (hydrochloride). Lercanidipine hydrochloride is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine hydrochloride has long lasting antihypertensive action and reno-protective effect.
    Lercanidipine-<sup>13</sup>C,d<sub>3</sub>-1 hydrochloride
  • HY-P1073
    ProTx-I
    		Inhibitor
    ProTx-I, a venom toxin of the tarantula Thrixopelma pruriens, is a potent, selective CaV3.1 channel blocker with IC50 values of 0.2 μM and 31.8 μM for hCaV3.1 and hCaV3.2 respectively. ProTx-I is also a potent blocker for voltage-gated Na+ channels and inhibits KV 2.1 channels.
    ProTx-I
  • HY-P3065
    Calcicludine
    		Inhibitor
    Calcicludine is a protein toxin from the venom of the green mamba that inhibits high-voltage-activated calcium channel, especially L-type calcium channel.
    Calcicludine
  • HY-19857
    Sulcardine sulfate
    Sulcardine (sulfate) is a novel multi-ion channel blocker with activity against Na+, K+ and Ca2+ channels. Sulcardine has antiarrhythmic activity.
    Sulcardine sulfate
  • HY-N0515R
    Ophiopogonin D (Standard)
    		Inhibitor
    Ophiopogonin D (Standard) is the analytical standard of Ophiopogonin D. This product is intended for research and analytical applications. Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years.
    Ophiopogonin D (Standard)
  • HY-126401
    Elgodipine
    		Inhibitor
    Elgodipine (IQB-875 free base) is an orally active dihydropyridine calcium antagonist and an antianginal compound. Elgodipine inhibits both T- and L-type calcium channels (IC50: 32 and 2.3 nM). Elgodipine lowers systemic vascular resistance and improves systolic cardiac function.
    Elgodipine
  • HY-135328S
    Norverapamil-d7
    		Inhibitor
    Norverapamil-d7 is a deuterium labeled Norverapamil ((±)-Norverapamil). Norverapamil, an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
    Norverapamil-d<sub>7</sub>
  • HY-W032013R
    1-Octanol (Standard)
    		Inhibitor
    1-Octanol (Standard) is the analytical standard of 1-Octanol. This product is intended for research and analytical applications. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents. 1-Octanol is a highly attractive biofuel with diesel-like properties.
    1-Octanol (Standard)
  • HY-113671
    Belfosdil
    		Inhibitor
    Belfosdil is an orally active and highly specific calcium channel blocker that also inhibits the activity of acyl coenzyme A cholesterol acyltransferase.
    Belfosdil
  • HY-N0215S13
    L-Phenylalanine-d
    		Antagonist
    L-Phenylalanine-d is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.
    L-Phenylalanine-d
  • HY-N0043R
    Ginsenoside Rd (Standard)
    		Inhibitor
    Ginsenoside Rd (Standard) is the analytical standard of Ginsenoside Rd. This product is intended for research and analytical applications. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.
    Ginsenoside Rd (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Calcium Channel Isoform Comparison

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