2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. CDK

CDK

Cyclin dependent kinase

CDK

Related Products

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CDKs (Cyclin-dependent kinases) are serine-threonine kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. CDKs are relatively small proteins, with molecular weights ranging from 34 to 40 kDa, and contain little more than the kinase domain. In fact, yeast cells can proliferate normally when their CDK gene has been replaced with the homologous human gene. By definition, a CDK binds a regulatory protein called a cyclin. Without cyclin, CDK has little kinase activity; only the cyclin-CDK complex is an active kinase.

There are around 20 Cyclin-dependent kinases (CDK1-20) known till date. CDK1, 4 and 5 are involved in cell cycle, and CDK 7, 8, 9 and 11 are associated with transcription.

CDK levels remain relatively constant throughout the cell cycle and most regulation is post-translational. Most knowledge of CDK structure and function is based on CDKs of S. pombe (Cdc2), S. cerevisia (CDC28), and vertebrates (CDC2 and CDK2). The four major mechanisms of CDK regulation are cyclin binding, CAK phosphorylation, regulatory inhibitory phosphorylation, and binding of CDK inhibitory subunits (CKIs).

CDK Isoform Specific Products:

CDK Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-155844
    CDK9-IN-26
    		Inhibitor
    CDK9-IN-26 (compound 1is a CDK9 inhibitor (IC50=0.18 μM). .
    CDK9-IN-26
  • HY-RS02403
    Cdk9 Rat Pre-designed siRNA Set A
    		Inhibitor

    Cdk9 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cdk9 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Cdk9 Rat Pre-designed siRNA Set A
    Cdk9 Rat Pre-designed siRNA Set A
  • HY-RS02386
    Cdk5 Rat Pre-designed siRNA Set A
    		Inhibitor

    Cdk5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cdk5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Cdk5 Rat Pre-designed siRNA Set A
    Cdk5 Rat Pre-designed siRNA Set A
  • HY-173007
    ALK/PI3K/AKT-IN-1
    		Inhibitor
    ALK/PI3K/AKT-IN-1 (Compound 45) inhibits the proliferation of cancer cell A549, H1975 and PC9 with an IC50 of 0.44, 0.83 and 1.51 μM. ALK/PI3K/AKT-IN-1 increases the expression of p21 and p27, inhibits the activity of CDK2 and p-Rb, arrests the cell cycle at G1 phase. ALK/PI3K/AKT-IN-1 inhibits the ALK/PI3K/AKT signaling pathway, promotes the depolarization of mitochondrial membrane potential, and inducing apoptosis in A549 cell. ALK/PI3K/AKT-IN-1 inhibits the formation and growth of A549 cell spheroids.
    ALK/PI3K/AKT-IN-1
  • HY-RS02400
    Cdk8 Rat Pre-designed siRNA Set A
    		Inhibitor

    Cdk8 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cdk8 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Cdk8 Rat Pre-designed siRNA Set A
    Cdk8 Rat Pre-designed siRNA Set A
  • HY-18629A
    (E/Z)-SU9516
    		Inhibitor
    (E/Z)-SU9516 is the isomer of SU9516 (HY-18629). SU9516 is a potent CDK2 inhibitor，with an IC50 of 22 nM，and also shows inhibitory effects on CDK1 and CDK4，with IC50s of 40，200 nM，respectively.
    (E/Z)-SU9516
  • HY-172128
    NUAK1-IN-2
    		Inhibitor
    NUAK1-IN-2 (Compound 24) is a NUAK1 (IC50 of 3.162 nM) and CDK2/4/6 inhibitor. NUAK1-IN-2 can be used in cancer, neurodevelopmental disorders and Alzheimer's disease research.
    NUAK1-IN-2
  • HY-113670
    CLK1/2-IN-2
    		Inhibitor 99.31%
    CLK1/2-IN-2 is CLK1 and CLK2 inhibitor with IC50 values of 1.1 nM and 2.4 nM, respectively. CLK1/2-IN-2 exhibits potent anti-cancer activities[1].
    CLK1/2-IN-2
  • HY-16297R
    Abemaciclib methanesulfonate (Standard)
    		Inhibitor
    Abemaciclib (methanesulfonate) (Standard) is the analytical standard of Abemaciclib (methanesulfonate). This product is intended for research and analytical applications. Abemaciclib methanesulfonate (LY2835219 methanesulfonate) is a selective CDK4/6 inhibitor with IC50s of 2 nM and 10 nM for CDK4 and CDK6, respectively.
    Abemaciclib methanesulfonate (Standard)
  • HY-158170
    CDK7-IN-28
    		Inhibitor
    CDK7-IN-28 (CDK7-1276) is a potent CDK7 inhibitor(IC50＜5 nM). CDK7-IN-28 can inhibit proliferation of MDA-MB-468 cell line by blocking cell cycle and inhibiting DNA replication.
    CDK7-IN-28
  • HY-RS02367
    Cdk16 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Cdk16 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cdk16 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Cdk16 Mouse Pre-designed siRNA Set A
    Cdk16 Mouse Pre-designed siRNA Set A
  • HY-170507
    CDK-IN-16
    		Inhibitor
    CDK-IN-16 (Compound 5g) is a CDK2/cyclin A2 inhibitor with an IC50 of 1.67 μM. CDK-IN-16 exhibits anticancer activity. The IC50 of CDK-IN-16 against the AGS cell line is 3.5 μM.
    CDK-IN-16
  • HY-149870
    PROTAC CDK9 degrader-8
    		Inhibitor
    PROTAC CDK9 degrader-8 (compound 21) is a potent PROTAC CDK9 degrader with an IC50 value of 0.01 μM. PROTAC CDK9 degrader-8 can be used in research of cancer.
    PROTAC CDK9 degrader-8
  • HY-RS02373
    Cdk19 Rat Pre-designed siRNA Set A
    		Inhibitor

    Cdk19 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cdk19 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Cdk19 Rat Pre-designed siRNA Set A
    Cdk19 Rat Pre-designed siRNA Set A
  • HY-RS02362
    CDK14 Human Pre-designed siRNA Set A
    		Inhibitor

    CDK14 Human Pre-designed siRNA Set A contains three designed siRNAs for CDK14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CDK14 Human Pre-designed siRNA Set A
    CDK14 Human Pre-designed siRNA Set A
  • HY-147602
    CDK7-IN-17
    		Inhibitor
    CDK7-IN-17 is a potent inhibitor of CDK7. CDK7-IN-17 is a pyrimidinyl derivative compound. CDK7-IN-17 has the potential for the research of various cancers, especially the cancer with transcriptional dysregulation (extracted from patent CN114249712A, compound 1).
    CDK7-IN-17
  • HY-P5428
    Cdc2 kinase substrate
    		Substrate
    Cdc2 kinase substrate is a biological active peptide. (The native peptide HATPPKKKRK is a substrate for cyclin-dependent protein kinase 1 (CDC2; CDK1).)
    Cdc2 kinase substrate
  • HY-169344
    CDK7-IN-31
    		Inhibitor
    CDK7-IN-31 (compound 13) is a potent and orally active cyclin-dependent kinase 7 (CDK7) inhibitor with a Kd value of 0.18 nM. CDK7-IN-31 shows anticancer activity.
    CDK7-IN-31
  • HY-111244
    DCB-3503
    		Inhibitor
    DCB-3503 is an allosteric modulator of heat shock cognate protein HSC70 and an inhibitor of Cyclin D1. DCB-3503 inhibits Cyclin D1 translation by allosterically modulating the ATPase and chaperone activities of HSC70. DCB-3503 may inhibit malignancies such as hepatocellular carcinoma or breast cancer with elevated expression of cyclin D1.
    DCB-3503
  • HY-133956
    3-ATA
    		Inhibitor
    3-ATA (NSC 680434) is a selective inhibitor of cyclin-dependent kinase 4 (CDK4) with neuroprotective and antitumor effects. 3-ATA can alleviate kainic acid (HY-N2309)-induced apoptosis in cerebellar granule neurons, which can be used in the study of neurodegenerative diseases.
    3-ATA
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
CDK Isoform Comparison

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