Adrenergic Receptor

Adrenergic Receptor Related Products (937):

By Effects:	Substrates (2) Inhibitors (167) Ligands (2) Controls (8) Agonists (282) Antagonists (269) Activators (36) Modulators (10) Degrader (1)

Cat. No.	Product Name	Effect	Purity

HY-19279A

JTH-601 free base
JTH-601 Free base is a novel alpha1-adrenoceptor antagonist that exhibits potent activity in inhibiting phenylephrine-induced contractions in lower urinary tract tissues. JTH-601 Free base competitively antagonizes alpha1-adrenoceptor-mediated contractile responses, demonstrating greater potency than prazosin or tamsulosin. JTH-601 Free base is anticipated to be effective in treating urinary outlet obstruction associated with benign prostatic hyperplasia.

HY-121318

LK 11
LK-11 is a tropane derivative that inhibits the passive uptake of noradrenalin (NA) by hypothalamic synaptic vesicles in vitro, similar to cocaine.

HY-B0452S1

Ritodrine-d₃ hydrochloride	Agonist
Ritodrine-d₃ (hydrochloride) is the deuterium labeled Ritodrine (hydrochloride). Ritodrine hydrochloride (DU21220 hydrochloride) is a β-2 adrenergic receptor agonist.

HY-132397S

Phenylephrone-d₃ hydrochloride	Agonist
Phenylephrone-d₃ (hydrochloride) is a deuterium labeled Phenylephrone hydrochloride. Phenylephrone hydrochloride can be used for the phenylephrone chemical delivery systems as safe and effective mydriatic agents.

HY-B1614R

Clenbuterol hydrochloride (Standard)	Agonist
Clenbuterol (hydrochloride) (Standard) is the analytical standard of Clenbuterol (hydrochloride). This product is intended for research and analytical applications. Clenbuterol (NAB-365) hydrochloride, a selective β2-adrenergic agonist, enhances skeletal muscle strength and hypertrophy. Clenbuterol hydrochloride induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage.

HY-17018

Napitane	Inhibitor
Napitane (A 75200) is a groundbreaking catecholamine uptake inhibitor that exhibits inhibitory effects on α-adrenergic receptors and shows promise for antidepressant activity in depression research.

HY-W751276

Ractopamine-¹³C₆
Ractopamine-¹³C₆ is the ¹³C-labeled Ractopamine (HY-113781). Ractopamine (LY031537) hydrochloride is a potent β-adrenergic receptor (βAR) agonist with K_d values of ~25 nM for pig β₁AR and β₂AR. Ractopamine hydrochloride is linked to protein metabolism. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs.

HY-16056A

Arbutamine hydrochloride	Agonist
Arbutamine hydrochloride is a short-acting, potent and nonselective β-adrenoceptor agonist. Arbutamine hydrochloride stimulates cardiac β₁-, tracheal β₂-, and adiopocyte β₃- adrenergic receptors. Arbutamine hydrochloride provides cardiac stress increases heart rate, cardiac contractility, and systolic blood pressure. Arbutamine hydrochloride can be used for cardiac stress agent .

HY-B0374AS

Moxonidine-¹³C,d₃ hydrochloride	Activator
Moxonidine-¹³C,d₃ hydrochloride is ¹³C and deuterated labeled Moxonidine hydrochloride (HY-B0374A). Moxonidine (BDF5895) is an orally active imidazoline type 1 receptor (I₁-R) agonist. Moxonidine activates imidazoline I₁ receptors and α₂ adrenoceptors, affecting oxidized low-density lipoprotein uptake. Moxonidine reduces atherosclerotic lesions and lowers blood pressure. Moxonidine can be used in the study of hypertension, heart failure, and atherosclerosis.

HY-B0661AS1

Tamsulosin-d₄ hydrochloride	Antagonist
Tamsulosin-d₄ (hydrochloride) is deuterium labeled Tamsulosin (hydrochloride). Tamsulosin hydrochloride ((R)-(-)-YM12617) is an inhibitor of α1-adrenergic receptor. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth in animal models.

HY-120935

(R)-Dabelotine
(R)-Dabelotine is the R-isomer of Dabelotine and functions as an adrenergic agonist, making it valuable in dementia research.

HY-B0192S

Alfuzosin-d₇
Alfuzosin-d₇ is the deuterium labeled Alfuzosin. Alfuzosin (SL 77499-10) is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin can be used in study of benign prostatic hyperplasia (BPH).

HY-118768

FMS586 free base
FMS586 free base is a selective neuropeptide Y Y5 receptor antagonist with oral activity. FMS586 can completely block the significant increase in adrenocorticotropic hormone (ACTH) and cortisol caused by the Y(5) selective agonist hPP. FMS586 also reversed the significant upregulation of adrenocorticotropic hormone (CRF) and antidiuretic hormone (AVP) mRNA expression induced by central injection of hPP. FMS586 provides the first evidence that selective stimulation of Y(5) receptors triggers activation of the HPA axis.

HY-133214

Cyclazosin hydrochloride	Antagonist
Cyclazosin hydrochloride is an α_1B-adrenergic receptor antagonist. Cyclazosin hydrochloride has high specificity for α-adrenergic receptors, with pK_i values of 9.23-9.57 and 8.18-8.41 for O/1A (O/la) and OflB (alb) adrenergic receptors, respectively. However, Cyclazosin hydrochloride cannot distinguish between cloned alb and alo adrenergic receptors, which have pK_i values of 9.23 and 9.28, respectively.

HY-12712

L-657743	Antagonist
L-657743 is a highly potent, highly selective, and orally active α₂-adrenoceptor antagonist. L-657743 can be used in the research of neurological diseases such as depression.

HY-17385S

Atomoxetine-d₅ hydrochloride
Atomoxetine-d₅ (hydrochloride) is the deuterium labeled Atomoxetine hydrochloride. Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively).

HY-B0352S3

Mirtazapine-d₄ hydrochloride	Antagonist
Mirtazapine-d₄ hydrochloride is deuterated labeled Mirtazapine (HY-B0352). Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT₂, 5-HT₃, histamine H1 receptor and α2-adrenoceptor antagonist with pK_i values of 8.05, 8.1, 9.3 and 6.95, respectively.

HY-105960A

Fenmetozole hydrochloride	Antagonist
Fenmetozole hydrochloride is an antagonist of ethanol, and also antagonizes α2-adrenergic receptor, which has antidepressant effect.

HY-10998

Salmefamol
Salmefamol (AH3923) is an orally active β2-adrenoceptor agonist. Salmefamol (AH3923) can be used in the study for asthma.

HY-134632

Dehydro silodosin	Antagonist
Dehydro silodosin (KMD-3241) is a selective α1A-adrenoceptor antagonist used in the study of benign prostatic hyperplasia.

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