Adrenergic Receptor

Adrenergic Receptor Related Products (937):

By Effects:	Inhibitors (167) Agonists (282) Antagonists (269) Activators (36) Modulators (10) Degrader (1) Substrates (2) Ligands (2) Controls (8)

Cat. No.	Product Name	Effect	Purity

HY-12760S

Indoramin-d₅	Antagonist
Indoramin-d₅ is deuterium labeled Indoramin, which is a piperidine antiadrenergic agent.

HY-B1308R

Adrenalone hydrochloride (Standard)	Agonist
Adrenalone (hydrochloride) (Standard) is the analytical standard of Adrenalone (hydrochloride). This product is intended for research and analytical applications. Adrenalone hydrochloride is an adrenergic agonist used as a topical vasoconstrictor and hemostatic. Adrenalone hydrochloride is an inhibitor of dopamine β oxidase. Adrenalone hydrochloride is chemically similar to known norepinephrine transporter (NET) ligands with an IC50 of 36.9 μM.

HY-149389

PNMT-IN-1	Inhibitor
PNMT-IN-1 (inhibtor 4) is a specific inhibitor of phenylethanolamine N-methyltransferas (PNMT) with a K_i value of 1.2 nM and a IC₅₀ value of 81 nM. PNMT-IN-1 also inhibits the vitality of DNMT1 and DNMT3b, with the IC₅₀ value of 61 μM and 17 μM, respectively, and has an antagonistic effect on epinephrine.PNMT-IN-1 (inhibtor 4 ) is a second generation inhibitor.

HY-120829S

Bisoprolol-d₅ hemifumarate
Bisoprolol-d₅ (hemifumarate) is deuterium labeled Bisoprolol (fumarate).

HY-121043

AA 497 free base	Agonist
AA 497 free base is an adrenergic beta-2 agonist. AA 497 free base is a bronchodilator.

HY-N10452

Methyl maslinate	Antagonist
Methyl maslinate is a β-adrenergic antagonist. Methyl maslinate is a potent cardiotonic and antidysrhythmic agent. Methyl maslinate has the potential for hypertension research.

HY-121043A

AA 497	Agonist
AA 497 is an adrenergic beta-2 agonist. AA 497 is a bronchodilator.

HY-103218

Talsupram hydrochloride	Inhibitor
Talsupram (hydrochloride) is a selective norepinephrine inhibitor with high affinity for norepinephrine transporter (NET) and can be used in the study of neuropathic pain.

HY-122300A

Oxaprotiline	Inhibitor
Oxaprotiline ((Rac)-Levoprotiline) is a potent Norepinephrine (NE)/Noradrenaline (NA) uptake inhibitor. Oxaprotiline has antidepressant activity.

HY-P10773

CTP-amiodarone	Inhibitor
CTP-amiodarone is a cell-penetrating conjugate of cardiomyocyte targeting peptide and Amiodarone (HY-14187). CTP-amiodarone exhibits antiarrhythmic efficacy through block of Na+, K+, Ca2+ channels and β-adrenergic receptors.

HY-A0267

Bitolterol	Agonist
Bitolterol is a β2-adrenergic agonist with bronchodilator activity. Bitolterol is classified as a prodrug and is primarily used for the suppression of respiratory diseases. Bitolterol is considered safe for use during breastfeeding, as the amount that can enter breast milk is very limited.

HY-12980A

Batefenterol Succinate	Agonist
Batefenterol Succinate (GSK961081 Succinate) is a first-of-its-kind inhaled bifunctional bronchodilator with smooth muscle relaxant properties. The activities of Batefenterol Succinate include acting as a smooth muscle parasympathetic antagonist and a beta2-adrenoceptor agonist. Batefenterol Succinate is used to improve respiratory function, especially in patients with chronic obstructive pulmonary disease (COPD).

HY-14299D

Indacaterol acetate	Agonist
Indacaterol acetate is an orally active ultra-long-acting β2 adrenergic receptor (ADRB2) agonist. Indacaterol acetate inhibits NF-κB activity in a β-arrestin2-dependent manner, preventing further lung damage and improving lung function in COPD (chronic obstructive pulmonary disorder). Indacaterol acetate can also be used in cardiovascular disease research.

HY-B0431AS1

Phenoxybenzamine (benzyl-2,3,4,5,6-d₅) hydrochloride	Antagonist
Phenoxybenzamine (benzyl-2,3,4,5,6-d₅) (hydrochloride) is the deuterium labeled Phenoxybenzamine hydrochloride. Phenoxybenzamine hydrochloride is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine hydrochloride also shows antitumor activity[1][2][3].

HY-178249

(1R,2S)-Dihydrobupropion	Inhibitor
(1R,2S)-Dihydrobupropion is a norepinephrine-dopamine reuptake inhibitor. (1R,2S)-Dihydrobupropion is one of the active metabolites of Bupropion (HY-B0403). (1R,2S)-Dihydrobupropion can be used for the researches of neurological disease and inflammation.

HY-10121S2

Asenapine-¹³C,d₃	Inhibitor
Asenapine-¹³C,d₃ is ¹³C and deuterated labeled Asenapine (HY-10121). Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), dopamine receptors (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder.

HY-B1421S1

Ractopamine-d₉ hydrochloride
Ractopamine-d₉ (LY031537-d₉) hydrochloride is the deuterium labeled Ractopamine hydrochloride (HY-B1421). Ractopamine (LY031537) hydrochloride is a potent β-adrenergic receptor (βAR) agonist with K_d values of ~25 nM for pig β₁AR and β₂AR. Ractopamine hydrochloride is linked to protein metabolism. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs.

HY-105925

Mefenidil
Mefenidil (MCN 2378) is a selective cerebral vasodilator that is not affected by beta-adrenergic blockade. Mefenidil can be used in the study of cardiovascular disease. In monkey models, mefenidil preferentially increases cerebral blood flow over systemic (femoral) blood flow. Mefenidil is also able to reduce systemic arterial pressure in anesthetized dogs.

HY-107327S1

Carazolol-d₇ hydrochloride
Carazolol-d₇ (hydrochloride) is the deuterium labeled Carazolol hydrochloride (HY-W517264). Carazolol hydrochloride is a highly potent antagonist of β₁/β₂ adrenoceptor. Carazolol hydrochloride is also a potent, selective β₃-adrenoceptor agonist. Carazolol hydrochloride can be used in the research of hypertension.

HY-B0773

Paroxetine mesylate	Inhibitor
Paroxetine mesylate, a phenylpiperidine derivative, is a potent and selective serotonin reuptake inhibitor (SSRI). Paroxetine mesylate is a very weak inhibitor of norepinephrine (NE) uptake but it is still more potent at this site than the other SSRIs.

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