2. Signaling Pathways
  3. GPCR/G Protein
  4. Adenosine Receptor
  5. Adenosine Receptor Isoform
  6. Adenosine Receptor Modulator

Adenosine Receptor Modulator

Adenosine Receptor Modulators (8):

Cat. No. Product Name Effect Purity
  • HY-112567
    TRR469
    		Modulator
    TRR469 is a positive allosteric modulator of the A1 adenosine receptor (A1AR). TRR469 significantly increases the affinity of 2-chloro N(6)-cyclopentyladenosine (CCPA) for A₁AR, increasing the number of receptors recognized by the agonist radioligand [³H]-CCPA. TRR469 shows significant effects in both anxiety and pain models. TRR469 can be used to study anxiety disorders and pain management.
  • HY-110012
    SCH-202676 hydrobromide
    		Modulator
    SCH-202676 hydrobromide is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 hydrobromide has antiviral activity and inhibits 3CLpro in a time-dependent manner with an IC50 value of 0.655 μM.
  • HY-147400
    Sipagladenant
    		Modulator 99.68%
    Sipagladenant (Compound I) is an orally active adenosine receptor A2A inverse agonist. Sipagladenant can be used in frontal lobe dysfunction research.
  • HY-U00116
    GP531
    		Modulator 99.17%
    GP531 is a potent, second-generation adenosine regulating agent, is pharmacologically silent under basal conditions but increases localized endogenous adenosine during ischemia.
  • HY-161810
    MRS8247
    		Modulator
    MRS8247 is a positive allosteric modulator (PAM) of the A3 adenosine receptor (A3AR) that can also slow the dissociation rate of agonists.
  • HY-178783
    MRS8454
    		Modulator
    MRS8454 is a positive allosteric modulator (PAM) of the A3 adenosine receptor (A3AR). MRS8454 can significantly enhance the maximum effect of the standard agonist Cl-IB-MECA by approximately 286%-300%, and significantly reduce its EC50 value. MRS8454 effectively enhances the ability of A3AR agonists to inhibit the cAMP accumulation induced by Forskolin (HY-15371). MRS8454 can be used for the development of molecular probes.
  • HY-120487
    VUF8507
    		Modulator
    VUF8507 is an allosteric modulator for adenosine A3 receptor with a Ki of 204 nM.
  • HY-155467
    MRS7935
    		Modulator
    MRS7935 (compound 15) is an A1AR positive allosteric modulator (PAM) with an EC50 of approximately 2 μM.