AChE

Acetylcholinesterase (AChE or acetylhydrolase) is a serine hydrolase that terminates the action of the neurotransmitter acetylcholine by hydrolyzing it into acetic acid and choline. AChE is found at mainly neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission. AChE plays an important role in the pathogenesis of neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative stress and aggregation of pathological proteins.

AChE Related Products (306):

By Type:	Pan (81) Selective (47)
By Effects:	Inhibitors (290) Agonist (1) Antagonists (2) Activators (4) Modulator (1) Chemical (1)

Cat. No.	Product Name	Effect	Purity

HY-118222

KBR 2822	Inhibitor
KBR 2822 is an inhibitor of neurological target esterase (NTE) and has an inhibitory effect on AChE. KBR 2822 can aggravate neurological damage under certain conditions, but does not cause neurological disease when used alone in the absence of direct neurotoxicity or biochemical damage.

HY-115919

AChE-IN-8	Inhibitor
AChE-IN-8 (Compound 19) is a potent inhibitor of AChE with an IC₅₀ of 1.95 μM. AChE-IN-8 has the potential for the research of Alzheimer's disease.

HY-172219

CUR-IPA	Inhibitor
CUR-IPA is a cholinesterase inhibitor, with IC₅₀ of 5.99, 59.30, and 60.66 μM for eAChE (electric eel), hAChE (human), and hBChE (human), respectively. CUR-IPA can scavenge free radicals and has antioxidant activity. CUR-IPA can be used in the research of cognitive dysfunction.

HY-168731

AChE/BChE-IN-25	Inhibitor
AChE/BChE-IN-25 (Compound 6e) is the orally active inhibitor for hAChE and eqBChE with IC₅₀ of 7.9 nM and 0.79 nM. AChE/BChE-IN-25 exhibits antioxidant activity, that scavenges free radical with IC₅₀ of 22.91 μM. AChE/BChE-IN-25 exhibits neuroprotective effects by reducing mitochondrial and cellular oxidative stress in the Drosophila Alzheimer's disease model. AChE/BChE-IN-25 ameliorates Scopolamine (HY-N0296)-induced spatial and cognitive memory impairment in mouse model.

HY-174399

AChE/BChE-IN-27	Inhibitor
AChE/BChE-IN-27 is a blood-brain barrier-permeable mixed inhibitor (Pe = 4.12) of AChE and BChE, with IC₅₀ values of 3.72 μM and 9.65 μM, respectively. AChE/BChE-IN-27 has potent antioxidant activity with an IC₅₀ value of 6.32 μM in the DPPH (HY-112053) assay and also exhibits potent in vitro antioxidant activity. AChE/BChE-IN-27 exhibits metal chelating properties. AChE/BChE-IN-27 has neuroprotective potential against oxidative stress. AChE/BChE-IN-27 significantly reduces intracellular reactive oxygen species (ROS). In in vivo experiments, AChE/BChE-IN-27 effectively restored AChE and BChE levels, improved cognition, and can be used for Alzheimer's disease (AD).

HY-N12388

AChE-IN-46	Inhibitor
AChE-IN-46 (compound 4), a β-cyclocostunolide, is an AChE inhibitor.

HY-151885

Dual AChE-MAO B-IN-3	Inhibitor
Dual AChE-MAO B-IN-3 (compound C10) is a potent dual AChE/MAO-B inhibitior, with IC₅₀ values of 0.58 and 0.41 μM, respectively. Dual AChE-MAO B-IN-3 is a dual-binding inhibitor bound to both the catalytic anionic site and peripheral anionic site of AChE. Dual AChE-MAO B-IN-3 can be used for Alzheimer’s disease (AD) research.

HY-122080

Memoquin	Inhibitor
Memoquin is an anti-amyloid and anti-oxidant multi-target-directed ligand. Memoquin is an orally active inhibitor of BACE-1 and AChE with IC₅₀ values of 108 and 1.55 nM, respectively. Memoquin is a cognitive enhancer that prevents the Aβ-induced neurotoxicity mediated by oxidative stress. Memoquin can be used for the research of Alzheimer’s disease (AD).

HY-19181

CI-1002	Antagonist
CI-1002 (PD 142676) is a potent acetylcholinesterase (AChE) and muscarinic antagonist. CI-1002 can be used for the study of the cognitive dysfunction of Alzheimer's disease (AD).

HY-N10384

AChE-IN-17	Inhibitor
AChE-IN-17 (compound 1) is a potent AChE inhibitor with an IC₅₀ value of 28.98 μM. AChE-IN-17 can significantly prevent H₂O₂-induced PC12 cell death, exhibiting excellent neuroprotective effect. AChE-IN-17 can be used for researching neurodegenerative diseases (NDs).

HY-143252

CEase-IN-1	Inhibitor
CEase-IN-1 (Compound A1H3) is a potent and selective cholesterol esterase (CEase) inhibitor with an IC₅₀ of 0.36 μM. CEase-IN-1 can be used for the research of hypercholesterolemia.

HY-175474

AChE-IN-93	Inhibitor
AChE-IN-93 (compound 4m) is a potent AchE inhibitor with an IC₅₀ of 29 nM. AChE-IN-93 can be used in Alzheimer's disease research.

HY-144272

AChE-IN-5	Inhibitor
AChE-IN-5 (compound 5) exhibits strong in vitro bioactivity against AChE/5-HT_1A/SERT and exhibits good BBB permeability. AChE-IN-5 shows IC₅₀ value 2.29 nM against AChE, EC₅₀ value 58.6 nM against 5-HT_1A and IC₅₀ value against SERT. Orally active.

HY-144388

ChE/Aβ1-42-IN-1	Inhibitor
ChE/Aβ1-42-IN-1 (compound 28) is a potent ChE and Aβ_1-42 aggregation inhibitor with IC₅₀s of 0.062, 0.767 and 1.227 µM for AChE, BuChE and Aβ_1-42 aggregation, respectively. ChE/β1-42-IN-1 shows excellent BBB penetration. ChE/Aβ1-42-IN-1 is a potent multi-targeted anti-Alzheimer's agent.

HY-179122

BChE-IN-45	Inhibitor
BChE-IN-45 is a competitive (cholinesterase) dual acting inhibitor (K_i = 11.13 μM). BChE-IN-45 has an IC₅₀ of 13.8 μM for BChE and 35.63 μM for AChE. BChE-IN-45 can be used for research on Alzheimer's disease.

HY-N10701

AChE/BChE-IN-11	Inhibitor
AChE/BChE-IN-11 (compound 1) is a potent is a dual AChE and BChE inhibitor with IC₅₀ values of 70 and 71 μM for AChE and BChE, respectively. AChE/BChE-IN-11 is a natural product that could be isolated from the leaf of artichoke . AChE/BChE-IN-11 can be used in research of Alzheimer’s disease (AD) research.

HY-144392

AChE/BuChE-IN-1	Inhibitor
AChE/BuChE-IN-1 (Compound 1), a chrysin derivative, is a selective butyrylcholinesterase (BuChE) inhibitor with an IC₅₀ of 0.48 μM. AChE/BuChE-IN-1 inhibits acetylcholinesterase (AChE) with an IC₅₀ of 7.16 μM. AChE/BuChE-IN-1 shows strong scavenging ·OH activities with a IC₅₀ of 0.1674 μM. AChE/BuChE-IN-1 inhibits reactive oxygen species (ROS), Aβ_1-42 aggregation (self-, Cu₂₊-induced, AChE-induced). AChE/BuChE-IN-1 has high BBB permeability and bioavailability and low cell toxicity. AChE/BuChE-IN-1 has the potential for Alzheimer' disease (AD) research.

HY-N15452

Eseramine	Inhibitor
Eseramine is a weak acetylcholinesterase inhibitor with an IC₅₀ value of 9300 nM. Eseramine is promising for research of diseases involving the regulation of acetylcholinesterase, such as glaucoma, myasthenia gravis, and protection against organophosphate poisoning.

HY-161150

AChE/BChE-IN-17	Inhibitor
AChE/BChE-IN-17 (compound 8m) is a potent and non-competitiveAChE and BChE inhibitor, with IC₅₀ values of 125.06 nM and 119.68 nM, respectively. AChE/BChE-IN-17 also inhibits α-glucosidase, with an IC₅₀ of 41050 nM.

HY-159898

AChE/BChE-IN-23	Inhibitor
AChE/BChE-IN-23 (Compound 6e) is an AChE/BChE inhibitor (IC₅₀: 0.91 μM, 1.19 μM and 1.01 μM for hAChE, eq BChE and hBChE, respectively). AChE/BChE-IN-23 has antioxidant activity and inhibits Aβ1-42 and Tau protein aggregation. AChE/BChE-IN-23 also inhibits microglial activation by reducing ROS release and mitochondrial injury. AChE/BChE-IN-23 suppresses NLRP3 inflammasome and pro-inflammatory cytokines in human microglial cells. AChE/BChE-IN-23 also reverses the Scopolamine (HY-N0296)-induced memory impairment in mice model.

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