2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipoxygenase

Lipoxygenase

LOX

Lipoxygenase

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Lipoxygenases (LOXs) are a family of enzymes that are responsible for the metabolism of arachidonic and docosahexaenoic acid and for the formation of several eicosanoids and docosanoids, including leukotrienes, lipoxins and neuroprotectins. Depending on cells' redox state and other milieu conditions, these enzymes are engaged in oxidative stress and cell death mechanisms or in cell protection. Lipoxygenases are lipid peroxidizing enzymes, implicated in the pathogenesis of inflammatory and hyperproliferative diseases, which represent potential targets for pharmacological intervention.

Lipoxygenases are classified on the basis of site of arachidonate oxygenation into 5-, 8-, 9-, 11-, 12- and 15-LOX. The prominent animal LOXs are 5-LOX, 8-LOX, 12-LOX and 15-LOX, while the plant LOXs are mostly 5-LOX and 15-LOX. Among these, 5-LOX is the most predominant isoform associated with the formation of 5-hydroperoxyeicosatetraenoic acid (5-HpETE) and other bioactive lipid mediators.

Lipoxygenase Isoform Specific Products:

Lipoxygenase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-127170R
    3-Hydroxycoumarin (Standard)
    		Inhibitor
    3-Hydroxycoumarin (Standard) is the analytical standard of 3-Hydroxycoumarin. This product is intended for research and analytical applications. 3-hydroxycoumarin is a potent and redox inhibitor of human 15-LOX-1. 3-hydroxycoumarin is recently demonstrated to protect sea urchin reproductive cells against ultraviolet B damage.
    3-Hydroxycoumarin (Standard)
  • HY-N15453
    Asperenone
    		Inhibitor
    Asperenone is an inhibitor of 15-lipoxygenase (15-LOX) with an IC50 value of 0.3 mM. It is also an inhibitor of platelet aggregation, with an IC50 value of 0.23 mM. Additionally, Asperenone has antifungal activity and can inhibit the growth of pathogenic fungi Ophiostoma crassivaginatum and O. piliferum. Asperenone can be used in the research of cardiovascular diseases and anti-infection fields.
    Asperenone
  • HY-14164S1
    Zileuton-13C2,15N
    		Inhibitor
    Zileuton-13C2,15N is 15N and 13C labeled Zileuton (HY-14164). Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties.
    Zileuton-<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N
  • HY-W706470
    (-)-Bornyl ferulate
    		Inhibitor
    (-)-Bornyl ferulate is a 5-lipoxygenase and COX inhibitor with IC50s of 10.4 μM and 12.0 μM, respectively.
    (-)-Bornyl ferulate
  • HY-114830
    Fenleuton
    		Inhibitor
    Fenleuton is a 5-lipoxygenase inhibitor. Fenleuton is promising for research of leukotriene-mediated inflammatory diseases.
    Fenleuton
  • HY-168768
    FerroLOXIN-1
    		Inhibitor
    FerroLOXIN-1 is a potent inhibitor of 15LOX-2 that selectively blocked production of pro-ferroptotic HOO-ETE-PE and protected against RSL3-induced ferroptosis. FerroLOXIN-1 closely interacted therein with 15LOX-2 only, and in particular with Y154, N155, W158.
    FerroLOXIN-1
  • HY-W028263
    6-Hydroxyflavanone
    		Inhibitor
    6-Hydroxyflavanone is a compound that can be isolated from the Muntingia calabura leaves. 6-Hydroxyflavanone targets cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and opioid and GABA-A receptors that has anti-inflammatory and anti-neuropathic pain potential. 6-Hydroxyflavanone can be used for the research of diabetes.
    6-Hydroxyflavanone
  • HY-116080
    SB 210661
    		Inhibitor
    SB 210661 is a potent and selective 5-lipoxygenase inhibitor.
    SB 210661
  • HY-W747562
    Leukotriene A 3 methyl ester
    Leukotriene A 3 methyl ester occurs from 5,8,11-eicosatrienoic acid via the 5-LO pathway.
    Leukotriene A 3 methyl ester
  • HY-U00260
    CMI977
    		Inhibitor
    CMI977 is a potent 5-Lipoxygenase (5-LO) inhibitor.
    CMI977
  • HY-U00347
    COX/5-LO-IN-1
    		Inhibitor
    COX/5-LO-IN-1 (Atreleuton analog) is an inhibitor of cylooxygenase and 5-lipoxygenase (5-LO), used for the research of inflammatory and allergic disease states.
    COX/5-LO-IN-1
  • HY-19205A
    CMI-392
    		Inhibitor
    CMI-392 is a dual 5-lipoxygenese inhibitor and platelet-activating factor (PAF) receptor antagonist with IC50s of 100 and 10 nM, respectively.
    CMI-392
  • HY-U00217
    AZD 4407
    		Inhibitor
    AZD 4407 is a potent 5-lipoxygenase inhibitor.
    AZD 4407
  • HY-U00170
    Bunaprolast
    		Inhibitor
    Bunaprolast (U66858) is a potent inhibitor of LTB4 production in human whole blood. Bunaprolast (U66858) also exhibits significant inhibition of lipoxygenase and TXB2 release.
    Bunaprolast
Cat. No. Product Name / Synonyms Application Reactivity
Lipoxygenase Isoform Comparison

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