2. Signaling Pathways
  3. Neuronal Signaling
  4. α-synuclein

α-synuclein

α-Syn

α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve terminals. α-synuclein regulates synaptic vesicle trafficking and subsequent neurotransmitter release. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) and other neurodegenerative disorders. Accumulation of misfolded oligomers and larger aggregates of α-synuclein defines multiple neurodegenerative diseases called synucleinopathies, but the mechanisms by which α-synuclein acts in neurodegeneration are unknown.

α-synuclein Isoform Specific Products:

α-synuclein Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P5043
    α-Synuclein (67-78) (human)
    α-Synuclein (67-78) (human) is the 67-78 fragment of α-Synuclein. α-Synuclein (67-78) (human) promotes network activity drive and blocks KCl-induced syt1L-ab uptake.
    α-Synuclein (67-78) (human)
  • HY-130398
    Aerophobin-2
    		Inhibitor
    Aerophobin-2 is a bromine compound, which can be isolated from sponge Verongia aerophoba. Aerophobin-2 inhibits aggregation of α-synuclein (α-syn) and phosphorylated α-synuclein (pSyn), exhibits neuroprotective efficacy.
    Aerophobin-2
  • HY-P3140
    α-Synuclein (61-75)
    α-Synuclein (61-75) is the 61-75 fragment of α-Synuclein. α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve terminals. α-Synuclein is a potential biomarker for Parkinson's disease (PD).
    α-Synuclein (61-75)
  • HY-163613
    NS163
    		Inhibitor
    NS163 is a α-Synuclein aggregation antagonist. NS163 can be used for study of Parkinson’s disease.
    NS163
  • HY-N15613
    α-Synuclein inhibitor 14
    		Inhibitor
    α-Synuclein inhibitor 14 (Compound 3) is a diarylheptanoid that can be isolated from Alpinia officinarum. α-Synuclein inhibitor 14 can inhibit the aggregation of α-synuclein, with an inhibition rate of 72.4% at a concentration of 10 μM. α-Synuclein inhibitor 14 can be used in the research of neurodegenerative diseases such as Parkinson's disease.
    α-Synuclein inhibitor 14
  • HY-168647
    KAC-50.1
    		Ligand
    KAC-50.1 is an α-Synuclein (α-syn) PET ligand, with a KD of 35 nM toward site 2 in recombinant α-syn fibrils.
    KAC-50.1
  • HY-107811R
    Harmol (Standard)
    		Degrader
    Harmol (Standard) is the analytical standard of Harmol (HY-107811). This product is intended for research and analytical applications. Harmol hydrochloride is an orally active β-carboline alkaloid. Harmol hydrochloride is a TFEB activator and monoamine oxidase inhibitor. Harmol can induce cell mitosis, Autophagy and Apoptosis. Harmol promotes the degradation of α-synuclein by regulating the autophagy-lysosomal pathway. Harmol has anti-tumor, anti-depressant and anti-aging activities. Harmol improves motor impairment in a mouse Parkinson's disease model.
    Harmol (Standard)
  • HY-169198
    GSD-16-24
    		Inhibitor
    GSD-16-24 is a lead compound that binds directly to the C-terminal IDR of α-syn monomers and fibrils, thereby preventing fibrils from binding to the receptor. GSD-16-24 can be used in Parkinson's research.
    GSD-16-24
  • HY-169288
    α-Synuclein modulator 1
    		Modulator
    α-Synuclein modulator 1 (Compound 7k) is a modulator for α-synuclein. α-Synuclein modulator 1 exhibits a maximal absorption and emission wavelength of 386 and 603 nm in ACN/PBS (1:1) buffer.
    α-Synuclein modulator 1
α-synuclein Isoform Comparison

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