2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-100813R
    Saclofen (Standard) 125464-42-8 98%
    Saclofen (Standard) is the analytical standard of Saclofen.
    Saclofen (Standard)
  • HY-100831R
    YM-58483 (Standard) 223499-30-7
    YM-58483 (Standard) is the analytical standard of YM-58483. This product is intended for research and analytical applications. YM-58483 (BTP2) is the first selective and potent inhibitor of CRAC channels and subsequent Ca2+ signals. YM-584832 is a blocker of store-operated Ca2+ entry (SOCE).
    YM-58483 (Standard)
  • HY-100921A
    Spaglumic Acid trisodium 57096-28-3 98%
    Spaglumic Acid (N-Acetylaspartylglutamic acid) trisodium is a neuropeptide that exists in millimolar concentrations in the brain and possesses anti-allergic activity.
    Spaglumic Acid trisodium
  • HY-100936R
    Etazolate hydrochloride (Standard) 35838-58-5
    Etazolate (hydrochloride) (Standard) is the analytical standard of Etazolate (hydrochloride). This product is intended for research and analytical applications. Etazolate hydrochloride (SQ 20009) is an orally active, selective inhibitor of type 4 phosphodiesterase (PDE4) with an IC50 of 2 μM. Etazolate hydrochloride is a γ-aminobutyric acid A (GABAA) receptor regulator. Etazolate hydrochloride is an α-secretase activator and induced the production of soluble amyloid precursor protein (sAPPα). Etazolate hydrochloride, a pyrazolopyridine class derivative, increases cAMP levels. Etazolate hydrochloride has anxiolyticlike, antidepressant-like and anti-inflammatory effects.
    Etazolate hydrochloride (Standard)
  • HY-100941R
    CCCP (Standard) 555-60-2 99.14%
    CCCP (Standard) is the analytical standard of CCCP. This product is intended for research and analytical applications. CCCP is an oxidative phosphorylation (OXPHOS) uncoupler. CCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation.
    CCCP (Standard)
  • HY-100954R
    2,4-Diamino-6-hydroxypyrimidine (Standard) 56-06-4
    2,4-Diamino-6-hydroxypyrimidine (Standard) is the analytical standard of 2,4-Diamino-6-hydroxypyrimidine. This product is intended for research and analytical applications. 2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis). 2,4-Diamino-6-hydroxypyrimidine blocks Tetrahydrobiopterin (BH4) synthesis and suppresses NO production.
    2,4-Diamino-6-hydroxypyrimidine (Standard)
  • HY-100977S
    Dimethoxycurcumin-d6 3006902-95-7 98%
    Dimethoxycurcumin-d6 is the deuterium labeled Dimethoxycurcumin (HY-100977). Dimethoxycurcumin is a derivative of Curcumin that has anti-inflammatory and antioxidant activities.
    Dimethoxycurcumin-d6
  • HY-101017R
    Palmitoylcarnitine chloride (Standard) 6865-14-1
    Eslicarbazepine acetate (Standard) is the analytical standard of Eslicarbazepine acetate. This product is intended for research and analytical applications. Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.
    Palmitoylcarnitine chloride (Standard)
  • HY-101018R
    Propionyl-DL-carnitine chloride (Standard) 18828-58-5
    Propionyl-DL-carnitine (chloride) (Standard) is the analytical standard of Propionyl-DL-carnitine (chloride). This product is intended for research and analytical applications. Propionyl-DL-carnitine chloride is a carnitine derivative. Propionyl-DL-carnitine chloride can be used for the research of inflammation.
    Propionyl-DL-carnitine chloride (Standard)
  • HY-101170R
    BU224 hydrochloride (Standard) 205437-64-5 98%
    BU224 (hydrochloride) (Standard) is the analytical standard of BU224 (hydrochloride). This product is intended for research and analytical applications. BU224 hydrochloride is a selective and high affinity imidazoline I2 receptor ligand, with a Ki of 2.1 nM. BU224 hydrochloride is sometimes used as an I2 receptor antagonist. BU224 hydrochloride exerts neuroprotective effects, with anti-inflammatory and anti-apoptotic properties. BU224 hydrochloride improves memory in 5XFAD mice, enlarging dendritic spines and reducing Aβ-induced changes in NMDARs. BU224 hydrochloride can be used for Alzheimer's disease research.
    BU224 hydrochloride (Standard)
  • HY-101179R
    Tesmilifene fumarate (Standard) 1185241-83-1 98%
    Tesmilifene (fumarate) (Standard) is the analytical standard of Tesmilifene (fumarate). This product is intended for research and analytical applications. Tesmilifene fumarate (DPPE fumarate), an H1C receptor antagonist, potentiates a wide range of cytotoxics and even to offer some protection of normal cells.
    Tesmilifene fumarate (Standard)
  • HY-101251R
    AMT hydrochloride (Standard) 21463-31-0 98%
    AMT (hydrochloride) (Standard) is the analytical standard of AMT (hydrochloride). This product is intended for research and analytical applications. AMT hydrochloride is a selective inhibitor of inducible NOS (iNOS) with Ki of 4.2 nM.
    AMT hydrochloride (Standard)
  • HY-101291R
    Iberdomide (Standard) 1323403-33-3
    Iberdomide (Standard) is the analytical standard of Iberdomide. This product is intended for research and analytical applications. Iberdomide (CC-220) is an orally active and potent cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC50 of ~150 nM for cereblon-binding affinity. Iberdomide, a derivative of Thalidomide (HY-14658), has antitumor and immunostimulatory activities.
    Iberdomide (Standard)
  • HY-101350A
    QX-314 21306-56-9 98%
    QX-314 is a membrane-impermeable quaternary Lidocaine (HY-B0185) derivative with sensory-selective blocking effects. QX-314 inhibits acid-induced esophageal hypersensitivity. QX-314 enters jugular ganglion cells via TRPV1 channels, blocks NaV1.8 channels, and thereby inhibits esophageal sensory conduction. QX-314 can alleviate acid-induced esophageal inflammation. QX-314 can be used for the research on gastroesophageal reflux disease (GERD).
    QX-314
  • HY-101405R
    Gestrinone (Standard) 16320-04-0
    Gestrinone (Standard) is the analytical standard of Gestrinone. This product is intended for research and analytical applications. Gestrinone (R2323) is a synthetic steroid hormone used to treat endometriosis. It inhibits leiomyoma cells with an IC50 of 43.67 μM. Gestrinone is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Gestrinone (Standard)
  • HY-101410A
    SDMA (p-hydroxyazobenzene-p′-sulfonate) 1266235-58-8 98%
    SDMA p-hydroxyazobenzene-p′-sulfonate is the p-hydroxyazobenzene-p′-sulfonate salt form of SDMA (HY-101410). SDMA p-hydroxyazobenzene-p′-sulfonate is an endogenous inhibitor of nitric oxide synthase (NO synthase) activity. SDMA p-hydroxyazobenzene-p′-sulfonate is an activator for NF-κB, and promotes the expression of IL-6 and TNF-α. SDMA p-hydroxyazobenzene-p′-sulfonate is stable in serum and plasma, and can be used as a kidney biomarker of hepatic and renal dysfunction.
    SDMA (p-hydroxyazobenzene-p′-sulfonate)
  • HY-101481R
    Flurbiprofen axetil (Standard) 91503-79-6 98%
    Flurbiprofen axetil (Standard) is the analytical standard of Flurbiprofen axetil. This product is intended for research and analytical applications. Flurbiprofen axetil is a non-selective COX inhibitor and a nonsteroidal anti-inflammatory agent with anti-inflammatory and analgesic effects. Flurbiprofen axetil inhibits basal-like breast cancer metastasis by inhibiting the MEK/ERK signaling pathway. Flurbiprofen axetil can promote neuroprotection after focal cerebral ischemia in rats by partially activating PPAR-γ. Flurbiprofen axetil alleviates cerebral ischemia/reperfusion injury by reducing inflammation in a transient global cerebral ischemia/reperfusion rat model. Flurbiprofen axetil can alleviate inflammatory responses and cognitive function in a mild cognitive impairment (MCI) SD rat model through the AMPKα/NF-κB signaling pathway.
    Flurbiprofen axetil (Standard)
  • HY-101499R
    GKT136901 (Standard) 955272-06-7
    GKT136901 (Standard) is the analytical standard of GKT136901. This product is intended for research and analytical applications. GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 is also a selective and direct scavenger of peroxynitrite. GKT136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 also has anti-inflammatory activity.
    GKT136901 (Standard)
  • HY-101546A
    Cavidine 32728-75-9 98%
    Cavidine ((+)-Cavidine) is a selective COX-2 inhibitor which possesses anti-inflammatory activity. Cavidine can be used for the research of skin injuries, hepatitis, cholecystitis, and scabies. Cavidine ameliorates LPS (HY-D1056)-induced acute lung injury via NF-κB signaling pathway.
    Cavidine
  • HY-101588R
    Gefapixant (Standard) 1015787-98-0
    Gefapixant (Standard) is the analytical standard of Gefapixant. This product is intended for research and analytical applications. Gefapixant is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC50 values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant can be used for the research of chronic cough and knee osteoarthritis.
    Gefapixant (Standard)
Cat. No. Product Name / Synonyms Application Reactivity