2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

PDF 93.1 MB

The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-13344R
    PF-8380 (Standard) 1144035-53-9
    PF-8380 (Standard) is the analytical standard of PF-8380. This product is intended for research and analytical applications. PF-8380 is a potent autotaxin inhibitor with an IC50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood.
    PF-8380 (Standard)
  • HY-133672
    (Rac)-Mono(3,5,5-trimethylhexyl) phthalate 297182-83-3 98%
    (Rac)-Mono(3,5,5-trimethylhexyl) phthalate is a important metabolite of commonly used phthalate plasticizers. (Rac)-Mono(3,5,5-trimethylhexyl) phthalate has immuno-suppressive effect.
    (Rac)-Mono(3,5,5-trimethylhexyl) phthalate
  • HY-133716
    Pantoprazole N-oxide 953787-60-5 98%
    Pantoprazole N-oxide (Impurity-VI) is the impurity found during the Pantoprazole (HY-17507) production. Pantoprazole is an inhibitor for proton pump (PPI) that can be used for diseases related to excessive gastric acid, such as gastric ulcers and gastroesophageal reflux disease (GERD).
    Pantoprazole N-oxide
  • HY-133724
    Vardenafil N-oxide 448184-48-3 98%
    Vardenafil N-oxide is a N-Oxide impurity of Vardenafil (HY-B0442).
    Vardenafil N-oxide
  • HY-133925
    6-O-Desmethyl donepezil 120013-56-1 98%
    6-O-Desmethyl donepezil is the metabolite of Donepezil (HY-14566). 6-O-Desmethyl donepezil is an inhibitor for hERG channel with an IC50 of 1 μM.
    6-O-Desmethyl donepezil
  • HY-133926
    5-O-Desmethyl donepezil 120013-57-2 98%
    5-O-Desmethyl donepezil is a metabolite of Donepezil (HY-14566). 5-O-Desmethyl donepezil is an inhibitor for hERG channel with an IC50 of 1.5 μM.
    5-O-Desmethyl donepezil
  • HY-133976
    Aceclofenac methyl ester 139272-66-5 98%
    Aceclofenac methyl ester (Impurity-D) is the impurity found during the Aceclofenac (HY-B0634). Aceclofenac is an orally active nonsteroidal anti-inflammatory agent (NSAID) with analgesic and anti-inflammatory properties.
    Aceclofenac methyl ester
  • HY-134021
    Prednisolone valerate acetate 72064-79-0 98%
    Prednisolone valerate acetate is an impurity of Prednisolone (HY-17463). Prednisolone is a potent, orally active corticosteroid and a glucocorticoid.
    Prednisolone valerate acetate
  • HY-13402R
    Varespladib (Standard) 172732-68-2
    Varespladib (Standard) is the analytical standard of Varespladib. This product is intended for research and analytical applications. Varespladib (LY315920) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively.
    Varespladib (Standard)
  • HY-134062
    7-Methyl-6-mercaptopurine 3324-79-6 98%
    7-Methyl-6-mercaptopurine (Compound 4) is a purine derivative and a substrate for thiopurine methyltransferase (TPMT) with Km and Vmax values of 231 μM and 2340 U/mg protein, respectively.
    7-Methyl-6-mercaptopurine
  • HY-134070
    2-O-Methyl PAF C-16 78858-44-3 98%
    2-O-Methyl PAF C-16 (ET-18-O-OCH3), a structural analog of the mediator of inflammation platelet-activating factor (PAF), is a cytotoxic ether lipid. 2-O-Methyl PAF C-16 stimulates TNF-α release in murine macrophages.
    2-O-Methyl PAF C-16
  • HY-134125
    Yohimbic acid ethyl ester 73840-32-1 98%
    Yohimbic acid ethyl ester (Compound 3a) is a selective ADRA2A antagonist with an IC50 of 31 nM.
    Yohimbic acid ethyl ester
  • HY-134138
    Indomethacin N-octyl amide 282728-65-8 98%
    Indomethacin N-octyl amide (Compound 2) is a potent and selective COX-2 inhibitor with an IC50 of 40 nM. Indomethacin N-octyl amide shows >1000-fold selectivity against COX-1 (IC50 of 66 µM).
    Indomethacin N-octyl amide
  • HY-13421R
    SR1001 (Standard) 1335106-03-0
    SR1001 (Standard) is the analytical standard of SR1001. This product is intended for research and analytical applications. SR1001 is a selective RORα and RORγt inverse agonist with Kis 172 and 111 nM, respectively.
    SR1001 (Standard)
  • HY-134235
    PAF C-16 carboxylic acid 129879-41-0 98%
    PAF C-16 carboxylic acid (Acetyl-CPGPC) is a phospholipid that possesses haptenic activity causing production of antibodies reactive with platelet-activating factor (PAF).
    PAF C-16 carboxylic acid
  • HY-134243
    6-T-GDP 16541-19-8 98%
    6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of azathioprine. 6-T-GDP can reduce the transcription of inflammatory factors and the expression of cell adhesion molecules by inhibiting the activity of Rac1, thereby inhibiting the migration of leukocytes and the occurrence of tissue inflammation.
    6-T-GDP
  • HY-134314
    8-Nitro-cGMP 913645-39-3 98%
    8-Nitro-cGMP is an electrophilic second messenger of redox signaling that can form a protein-S-cGMP adduct in s-guanylation process. 8-Nitro-cGMP is an autophagy inducer. 8-Nitro-cGMP promotes RANKL-induced osteoclast differentiation from macrophages. 8-Nitro-cGMP has vasodilator effect, and ameliorates the vascular endothelial dysfunction in diabetic mice.
    8-Nitro-cGMP
  • HY-134369
    Ap4C tetrasodium 1352921-13-1 98%
    Ap4C tetrasodium is a dinucleoside polyphosphate containing purine and pyrimidine base moieties. Ap4C tetrasodium acts as a signaling molecule by binding to specific P2Y receptors, activating P2Y2 and P2Y4 receptors in platelets, leading to platelet aggregation and other cellular responses. Ap4C tetrasodium can be used for research in inflammation and blood coagulation.
    Ap4C tetrasodium
  • HY-134375
    cAIMP 1507367-51-2 98%
    cAIMP (Cyclic Adenosine-Inosine Monophosphate) is an effective synthetic cyclic dinucleotide. cAIMP activates IRF and NF-κB in the THP1 human monocyte reporter cell line (THP1-Dual). cAIMP induces the secretion of IFNs and pro-inflammatory cytokines in vitro in human blood, with an EC50 of 6.4 μmol/L.
    cAIMP
  • HY-13448R
    Nedocromil (Standard) 69049-73-6
    Nedocromil (Standard) is the analytical standard of Nedocromil. This product is intended for research and analytical applications. Nedocromil suppresses the action or formation of multiple mediators, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
    Nedocromil (Standard)
Cat. No. Product Name / Synonyms Application Reactivity