2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-134996
    N-Acetyl-2-carboxybenzenesulfonamide 849067-18-1 98%
    N-Acetyl-2-carboxybenzenesulfonamide is an orally active COX-1 and COX-2 inhibitor with IC50s of 0.06 μM and 0.25 μM, respectively. N-Acetyl-2-carboxybenzenesulfonamide shows anti-inflammatory activity.
    N-Acetyl-2-carboxybenzenesulfonamide
  • HY-135089
    Autotaxin-IN-5 2156655-99-9 98%
    Autotaxin-IN-5 (compound 63), extracted from patent WO2018212534A1, is an Autotaxin inhibitor. Autotaxin-IN-5 has the potential to treat idiopathic pulmonary fibrosis.
    Autotaxin-IN-5
  • HY-13511S
    Rupatadine-d6 D-tartrate 98%
    Rupatadine-d6 (D-tartrate) is deuterated labeled Rupatadine (HY-13511). Rupatadine (UR-12592) is a potent, orally active and long-lasting dual PAF/H1 antagonist, with Kis of 0.55 μM and 0.1 μM, respectively. Rupatadine can be used for the research of allergic rhinitis and urticaria.
    Rupatadine-d6 D-tartrate
  • HY-135181
    Daunosamnyl-daunorubicin 28008-54-0 98%
    Daunosamnyl-daunorubic, an antibiotic, can bind calf thymus DNA.
    Daunosamnyl-daunorubicin
  • HY-135284
    FTY720-Mitoxy 1604816-11-6 98%
    FTY720-Mitoxy is a fingolimod hydrochloride (HY-12005) derivative with neuroprotective and PP2A activating activities. FTY720-Mitoxy has the property of targeting mitochondria. In addition, FTY720-Mitoxy protects neurons by reducing inflammatory responses and is used in the study of neurodegenerative diseases such as Parkinson's disease.
    FTY720-Mitoxy
  • HY-135288
    L-649923 114370-57-9 98%
    L-649923 is an orally active CysLT1 antagonist. L-649923 reduced the incidence of gastritis in an animal model of acute gastric mucosal injury. L-649923 can be used in research on diseases such as asthma and gastritis.
    L-649923
  • HY-135301
    Flavanone hydrazone 1692-46-2 98%
    Flavanone hydrazine is a potent non-steroidal anti-inflammatory agent. Flavanone hydrazine effectively inhibits lens protein-induced ocular inflammation.
    Flavanone hydrazone
  • HY-135373
    Desfluoro-atorvastatin 433289-84-0 98%
    Desfluoro-atorvastatin is an impurity of Atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids.
    Desfluoro-atorvastatin
  • HY-135374
    (3R,5S)-Atorvastatin sodium 131275-93-9 98%
    (3R,5S)-Atorvastatin sodium is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
    (3R,5S)-Atorvastatin sodium
  • HY-135375
    O-Methyl Atorvastatin calcium 887196-29-4 98%
    O-Methyl Atorvastatin (hemicalcium) is an impurity of Atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids.
    O-Methyl Atorvastatin calcium
  • HY-135378
    Atorvastatin ethyl ester 1146977-93-6 98.16%
    Atorvastatin ethyl ester is a derivative of Atorvastatin and displays strong inhibition of the 9-cis-RA-induced Gal4 reporter activity.
    Atorvastatin ethyl ester
  • HY-135382
    PROTAC IRAK4 degrader-2 2374122-27-5 98%
    PROTAC IRAK4 degrader-2 (Compound 9) is a PROTAC-based IRAK4 degrader that affords potent IRAK4 degradation with a DC50 in peripheral blood mononuclear cells (PBMCs) cells of 151 nM. PROTAC IRAK4 degrader-2 induce a reduction of IRAK4 protein levels with a DC50 of 36 nM in PBMC cells. PROTAC IRAK4 degrader-2 also leads to the inhibition of multiple cytokines in PBMCs.
    PROTAC IRAK4 degrader-2
  • HY-135386
    5β-​Dutasteride 957229-52-6 98%
    5β-Dutasteride is the S configuration of Dutasteride. 5β-Dutasteride is a potent inhibitor of both 5 alpha-reductase isozymes.
    5β-​Dutasteride
  • HY-135408
    Trimetazidine-N-oxide 1644530-89-1 98%
    Trimetazidine-N-oxide is the major active metabolite of Trimetazidine. Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM. Trimetazidine is an effective antianginal agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties.
    Trimetazidine-N-oxide
  • HY-135413
    MeCY5-NHS ester 937739-58-7
    MeCY5-NHS estera is a reactive dye. MeCY5-NHS estera can be used for the labeling of proteins and nucleic acids.
    MeCY5-NHS ester
  • HY-135495
    AM-0466 1642113-59-4 98%
    AM-0466 is a sodium channel inhibitor with nanomolar levels of NaV1.7 inhibitory activity. AM-0466 exhibits potent pharmacodynamic activity in a NaV1.7-dependent histamine-induced itch model. AM-0466 also showed significant analgesic effects in capsaicin-induced pain models. After optimizing its pharmacokinetic properties, AM-0466 was advanced into in vivo targeting and efficacy models for testing.
    AM-0466
  • HY-135511
    Nor-Cerpegin 145887-88-3 98%
    Nor-Cerpegin is an analog of Cerpegin. Cerpegin, a pyridinone-fused c-lactone, is an inhibitor of 20S proteasome. Cerpegin can be used as a tranquillizer, anti-inflammatory, analgesic and antiulcer.
    Nor-Cerpegin
  • HY-135562
    Ascofuranone 38462-04-3 98%
    Ascofuranone, a prenylphenol antibiotic, is a potent and selective trypanosome alternative oxidase (TAO) inhibitor. Ascofuranone has inhibitory activity against human dihydroorotate dehydrogenase (DHODH). Ascofuranone has diverse physiological activities, including antibiotic, hypolipidemic, anti-inflammatory, and anti-cancer.
    Ascofuranone
  • HY-13557R
    Ascomycin (Standard) 104987-12-4
    Ascomycin (Standard) is the analytical standard of Ascomycin. This product is intended for research and analytical applications. Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research[1][2].
    Ascomycin (Standard)
  • HY-13559A
    Atiprimod dimaleate 183063-72-1 98%
    Atiprimod (Azaspirane) (dimaleate) is a STAT3 inhibitor with antitumor, anti-inflammatory, and anti-angiogenic activities. Atiprimod blocks the signaling pathways of IL-6 and VEGF by inhibiting the phosphorylation of signal transducer and activator of STAT3. Atiprimod blocks the JAK-STAT signaling pathway by inhibiting the phosphorylation of JAK2 and JAK3. Atiprimod also inhibits cell proliferation, induces cell cycle arrest, and induces autophagy and apoptosis. Atiprimod triggers persistent ER stress-mediated apoptosis in breast cancer cells by activating the PERK/eIF2α/ATF4/CHOP axis and inhibiting the nuclear translocation of STAT3/NF-κB. Atiprimod shows great anti-tumor activities in tumor xenograft mouse models. Atiprimod can be used for the study of pituitary adenoma, breast cancer, multiple myeloma and acute myeloid leukemia (AML).
    Atiprimod dimaleate
Cat. No. Product Name / Synonyms Application Reactivity