2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-160021
    RORγt agonist 4 2241769-59-3 98%
    RORγt agonist 4 (compound 14) is a potent and selective agonist of RORγt. RORγt agonist 4 significantly enhances metabolic stability. RORγt agonist 4 improves the situation of tumor models of mouse B16F10 melanoma and LLC lung adenocarcinoma.
    RORγt agonist 4
  • HY-160026
    IL-17 modulator 8 1608097-49-9 98%
    IL-17 modulator 8 (compound 286) is an orally active modulator of IL-17. IL-17 modulator 8 significantly reduces IL-6, IFN-γ, and edema. IL-17 modulator 8 can used in study arthritis.
    IL-17 modulator 8
  • HY-160027
    TNF-alpha-IN-1 98%
    TNF-alpha-IN-1 (compound 202) is an orally active inhibitor of TNF-alpha. TNF-alpha-IN-1 has anti-inflammatory activity which can used in study rheumatoid arthritis, psoriasis, and asthma.
    TNF-alpha-IN-1
  • HY-160028
    IL-17 modulator 9 1449211-26-0 98%
    IL-17 modulator 9 (compound 453) is an orally active modulator of IL-17. IL-17 modulator 9 significantly reduces IL-6, IFN-γ, and edema. IL-17 modulator 9 can used in study inflammation.
    IL-17 modulator 9
  • HY-160040
    Cobitolimod 1226822-98-5
    Cobitolimod is a DNA oligonucleotide agonist of TLR-9 with anti-inflammatory activity. Cobitolimod suppresses Th17 cells and induces anti-inflammatory FoxP3 and IL-10 expression, inhibiting the IL-17 signaling pathway.
    Cobitolimod
  • HY-160073
    Florensocatib 2762114-61-2 98%
    Florensocatib (compound 1) is a potent inhibitor of DPP1. Florensocatib can used in study bronchiectasis.
    Florensocatib
  • HY-160167
    Birelentinib 2662512-15-2 98%
    Birelentinib (compound cpd15) is an inhibitor of Bruton's tyrosine kinase (BTK) and mutant BTK with IC50 values of 6.72 and 6.11 nM, respectively.
    Birelentinib
  • HY-160169
    Necrosis inhibitor 2 2258671-03-1 98%
    Necrosis inhibitor 2 (Compound B19) is a cell necrosis inhibitor. Necrosis inhibitor 2 can be used to study diseases related to the necrosis pathway, including inflammation, tumors, metabolic diseases and neurodegenerative diseases.
    Necrosis inhibitor 2
  • HY-160180
    Glucocorticoid receptor agonist-4 Ala-Ala-Mal 3014393-37-1 98%
    Glucocorticoid receptor agonist-4 Ala-Ala-Mal (Compound Preparation 9) is an anti-human TNFα antibody-glucocorticoid receptor agonist (GC) conjugate. Glucocorticoid receptor agonist-4 Ala-Ala-Mal can be used in the study of autoimmune and inflammatory diseases.
    Glucocorticoid receptor agonist-4 Ala-Ala-Mal
  • HY-160181
    INX-SM-3 2734877-96-2 98%
    INX-SM-3 is a novel glucocorticosteroid . INX-SM-3 can be used as a glucocorticosteroid-linker connected to ADCs.
    INX-SM-3
  • HY-160182
    INX-P 2734878-02-3 98%
    INX-P is glucocorticosteroid-target antibody drug conjugate (ADC).
    INX-P
  • HY-160216
    RIPK1-IN-18 2682889-01-4 98%
    RIPK1-IN-18 (compound i) is a potent inhibitor of RIPK1. RIPK1-IN-18 can be used in autoimmune diseases research.
    RIPK1-IN-18
  • HY-160222
    HSV-60mer sodium
    HSV-60mer sodium is a 60 bp double-stranded oligonucleotide containing viral DNA motifs that derive from the herpes simplex virus 1 (HSV-1) genome. Transfected HSV-60 has been shown to potently induce IFN-β in a Toll-like receptor (TLR)-, DNA-dependent activator of IRFs (DAI)-, and RNA polymerase III (Pol III)-independent, but STING-, TBK1- and IFN regulatory factor 3 (IRF3)-dependent manner.
    HSV-60mer sodium
  • HY-160223
    ssVACV-70mer sodium
    ssVACV-70mer sodium is a 70 bp single-stranded oligonucleotide containing viral DNA motifs that derive from the vaccinia virus DNA. Unlike its double-stranded counterpart dsVACV 70mer, ssVACV 70mer is not IFN-inducer.
    ssVACV-70mer sodium
  • HY-160224
    dsVACV-70mer sodium
    dsVACV-70mer sodium is a 70 bp double-stranded oligonucleotide containing viral DNA motifs derived from vaccinia virus DNA. dsVACV-70mer sodium has potently induces IFN-β via a STING-dependent manner.
    dsVACV-70mer sodium
  • HY-160227
    ORN 06 1116698-32-8
    ORN 06 (Compound R-0006), a U-rich single-stranded RNA (containing 6 repeats of the UUG sequence motif), is a TLR7/8 agonist. ORN 06 stimulates human TLR7/8-mediated or murine TLR7-mediated immunity.
    ORN 06
  • HY-160228
    ORN 02 937769-72-7
    ORN 02 is a synthetic single-stranded U-rich RNA and contains 6 repeats of UUAU sequence motif. The AU-rich oligoribonucleotides (ORNs) are able to stimulate TLR8.
    ORN 02
  • HY-160433
    TNF-α-IN-12 364039-56-5 98%
    TNF-α-IN-12 is a TNF-α inhibitor with IC50 of 0.1 μM. TNF-α-IN-12 can decrease the TNF-α blood levels.
    TNF-α-IN-12
  • HY-160434
    TNF-α-IN-13 364039-48-5 98%
    TNF-α-IN-13 is a potent TNFα inhibitor with an IC50 of <0.6 μM. TNF-α-IN-13 has antiinflammatory properties (WO2001072735A2; example 6).
    TNF-α-IN-13
  • HY-160435
    TNF-α-IN-14 364039-54-3 98%
    TNF-α-IN-14 is a potent and selective TNFα inhibitor with an IC50 value of 1.1 µM. TNF-α-IN-14 shows antiinflammatory properties (WO2001072735A2; compound 12).
    TNF-α-IN-14
Cat. No. Product Name / Synonyms Application Reactivity