2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-121594
    GSK-269984B 892664-17-4 98%
    GSK-269984B is a potent EP1 antagonist. GSK-269984B has the potential for inflammatory pain research.
    GSK-269984B
  • HY-121611
    HI-236 233271-65-3 98%
    HI-236 is a potent non-nucleoside inhibitor of HIV-1 reverse transcriptase.? HI-236 inhibits HIV activity (wild type HTLVIIB IC50p24 < 0.001 μM).
    HI-236
  • HY-121621
    RO5101576 1123155-95-2 98%
    RO5101576 is a potent LTB4 receptor antagonist with activity to inhibit LTB4-induced calcium mobilization and chemotaxis of human neutrophils. RO5101576 significantly attenuated LTB4-induced pulmonary eosinophilia in guinea pigs. RO5101576 inhibited allergen- and ozone-induced pulmonary neutrophilia in nonhuman primates with efficacy comparable to that of budesonide. RO5101576 had no effect on LPS-induced neutrophilia in guinea pigs and cigarette smoke-induced neutrophilia in mice and rats. RO5101576 performed well in toxicology studies and was well tolerated.
    RO5101576
  • HY-121662
    Lenaldekar 418800-15-4 98%
    Lenaldekar (LDK) inhibits human and murine T-cell expansiomn. Lenaldekar inhibits autoimmune T cell response. Lenaldekar also induces cancer cell apoptosis. Lenaldekar can be used for T-cell mediated autoimmune diseases research.
    Lenaldekar
  • HY-121678
    Tetridamine 17289-49-5 98%
    Tetridamine ((POLI-67) ) is a non-steroidal anti-inflammatory agent and shows a marked reduction of paw swelling and pain sensibility.
    Tetridamine
  • HY-121681
    K 308 36774-74-0 98%
    K 308 is a non-steroid antiinflammatory agent.
    K 308
  • HY-121711
    5-OH-HxMF 1176-88-1 98%
    5-OH-HxMF is a hydroxylated polymethoxyflavone that has anti-inflammatory, anticancer, neurotrophic and neuroprotective activities.
    5-OH-HxMF
  • HY-121743
    Ro26-4550 193744-04-6 98%
    Ro26-4550 is a low micromolar antagonist of IL-2/IL-2Rα binding with an IC50 value of 3 μM.
    Ro26-4550
  • HY-121856
    Flumizole 36740-73-5 98%
    Flumizole, a derivative of substituted 5,6-diaryl-2,3-dihydroimidazo[2,1-b]thiazoles, was synthesized and evaluated for its immunoregulatory and anti-inflammatory properties in animal models such as rat adjuvant-induced arthritis and mouse oxazolone-induced contact sensitivity assays. This compound class combines structural elements from flumizole and levamisole, aiming to enhance therapeutic efficacy. Symmetrically substituted 5,6-diaryl compounds with specific alkyl heteroatom or halogen substitutions showed optimal potency in the arthritis model. However, variations in activity were less consistent in the contact sensitivity assay. Flumizole and related compounds demonstrate potential as dual-action agents, targeting inflammation and immune modulation, offering promise for therapeutic development in immune-related disorders.
    Flumizole
  • HY-121917
    Ro 31-7837 120280-33-3 98%
    APTO-253 (LOR-253) hydrochloride is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 hydrochloride mediates anticancer activity via induction of Kruppel-like factor 4 (KLF4) tumor suppressor. APTO-253 hydrochloride exhibits antiarthritic activity.
    Ro 31-7837
  • HY-121927
    Mobiletrex 238074-89-0 98%
    Mobiletrex is an anti folate and dihydrofolate reductase inhibitor that can be used in research on rheumatoid arthritis.
    Mobiletrex
  • HY-121975
    N-Cyclohexanecarbonylpentadecylamine 702638-84-4 98%
    N-Cyclohexanecarbonylpentadecylamine (Compound 1) is an inhibitor of N-Acylethanolamine hydrolyzing acid amidase (NAAA) with an IC50 of 4.5 μM. N-Cyclohexanecarbonylpentadecylamine can be used in the research of inflammation and pain.
    N-Cyclohexanecarbonylpentadecylamine
  • HY-121987
    15(S)-HEDE 92693-04-4 98%
    15(S)-HEDE (Compound 8) is an analogue of 15-HEDE (HY-121987A) that inhibits 5-lipoxygenase with an IC50 value of 26 μM. 15(S)-HEDE is promising for research of inflammatory disease.
    15(S)-HEDE
  • HY-121996
    Prostaglandin E2 Ethanolamide 194935-38-1 98%
    Prostaglandin E2 Ethanolamide (PGE2-EA), an analog of PGE2, can be formed enzymatically following COX-2 oxygenation of endocannabinoids. Prostaglandin E2 Ethanolamide (PGE2-EA) could modulate the production of the proinflammatory cytokine TNF-α in human blood and human monocytic cells.
    Prostaglandin E2 Ethanolamide
  • HY-122049
    ENMD-1068 hydrobromide 644961-61-5 98%
    ENMD-1068 hydrobromide is a potent PAR2 antagonist. ENMD-1068 hydrobromide attenuates joint inflammation in a dose-dependent manner. ENMD-1068 hydrobromide can be used in research of joint inflammation.
    ENMD-1068 hydrobromide
  • HY-122082
    Methopterin 2410-93-7 98%
    Methopterin inhibits osteoclasts proliferation. Methopterin inhibits the activation and bone resorption function of osteoclasts, and induced osteoclasts apoptosis.
    Methopterin
  • HY-122154
    FR234938 256461-79-7 98%
    FR234938 is a non-nucleoside adenosine deaminase inhibitor with an IC50 of 17 nM for recombinant human adenosine deaminase enzyme. FR234938 has anti-rheumatic and anti-inflammatory effects.
    FR234938
  • HY-122167
    L-869298 362718-73-8 98%
    L-869298 is a potent and selective PDE4 inhibitor with an IC50 of 0.5 nM for PDE4A. L-869298 shows less active against hERG potassium channel.
    L-869298
  • HY-122179
    NUCC-555 1060469-90-0 98%
    NUCC-555 is an activin antagonist. NUCC-555 interacts with Trp25, Trp28, Phe55, Tyr93, Lys103, and Asn107 in the Activin A binding pocket. NUCC-555 blocks Activin A-mediated hepatic stellate cells (HSCs) activation. NUCC-555 promotes liver regeneration and halts fibrosis progression in chronic liver disease models. NUCC-555 inhibits Activin A-mediated ovarian cell proliferation. NUCC-555 decreases FSH levels in ovariectomized mice.
    NUCC-555
  • HY-122192
    ICAM-1988 444169-80-6 98%
    ICAM-1988 is a small molecule lymphocyte function-associated antigen-1 (LFA-1) antagonist that disrupts the LFA-1/ICAM-1 interaction and has anti-inflammatory activity.
    ICAM-1988
Cat. No. Product Name / Synonyms Application Reactivity