2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P2034
    Cargutocin 33605-67-3 98%
    Cargutocin, an oxytocin analogue, targets the oxytocin receptor and acts as a uterine contraction agent.
    Cargutocin
  • HY-P2039
    Retrobradykinin 5991-13-9 98%
    Retrobradykinin has the reverse sequence of Bradykinin (HY-P0206). Retrobradykinin exhibits no kinin activity and can be used as a negative control for Bradykinin.
    Retrobradykinin
  • HY-P2067
    Argtide 138111-66-7 98%
    Argtide is a luteinizing hormone-releasing hormone (LHRH) antagonist. Argtide is used in endometriosis and cancer-related research.
    Argtide
  • HY-P2075
    EMD 55068 126784-34-7 98%
    EMD 55068 is a renin antagonist. EMD 55068 inhibits the uptake of taurocholate.
    EMD 55068
  • HY-P2110
    RS-18286 109458-76-6 98%
    RS-18286 is a potent luteinizing-hormone (LH)-releasing hormone (LHRH) antagonist. RS-18286 blocks the pituitary LHRH receptor and suppresses pituitary luteinizing-hormone (LH) secretion and reduce serum concentrations of gonadal steroids.
    RS-18286
  • HY-P2168
    Demoxytocin 113-78-0 98.34%
    Demoxytocin, a heterodetic cyclic peptide, is an analog of oxytocin. Demoxytocin affects the permeability of the cell membrane, increasing the content of calcium ions in smooth muscle cells, increasing its contraction. Demoxytocin also stimulates the contraction of smooth muscles of the uterus. Demoxytocin has the function of oxytocin. Demoxytocin can be used to research stimulation of labor in cases of premature rupture.
    Demoxytocin
  • HY-P2191
    KISS1-305 872717-97-0 98%
    KISS1-305, the Metastin/Kisspeptin analog, is a prototype peptide and a chemical probe. KISS1-305 has suboptimal KISS1R agonistic activity, and resists plasma protease degradation.
    KISS1-305
  • HY-P2419
    [Ala6]-LHRH 51278-35-4 98%
    [Ala6]-LHRH is a synthetic luteinizing hormone-releasing hormone agonist, demonstrating effective stimulation of pituitary luteinizing hormone secretion. [Ala6]-LHRH enhances reproductive hormone regulation, contributing to fertility treatments. [Ala6]-LHRH plays a crucial role in managing conditions related to hormone imbalances.
    [Ala6]-LHRH
  • HY-P2446
    ORG 30276 83539-08-6 98%
    ORG 30276 (APTAA-LHRH) is a potent GnRH antagonist that effectively reduces serum LH and FSH levels in male rats. ORG 30276 significantly decreases unoccupied pituitary GnRH receptors, leading to suppressed gonadotropin secretion. ORG 30276 treatment results in a considerable reduction in mRNA levels of gonadotropin beta-subunits in the pituitary gland. ORG 30276's effects on gonadotropin dynamics can be selectively reversed by the replacement of specific sex steroids, with androgens being particularly effective for the FSH beta-subunit mRNA levels.
    ORG 30276
  • HY-P2703
    Peptide YY (pig) 81858-94-8 98%
    Peptide YY (pig) is a 36 amino acid gastrointestinal peptide, can be isolated from porcine duodenum. Peptide YY (pig) decreases appetite and food-intake by activation of the Y2 receptor. Peptide YY (pig) is present mainly in pancreatic endocrine cells with effect on both intestinal motility and the cardiovascular system.
    Peptide YY (pig)
  • HY-P2706
    Granuliberin R 64704-41-2 98%
    Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. Granuliberin R is a dodecapeptide, can act on rat peritoneal mast cell to liberate granules and release histamine.
    Granuliberin R
  • HY-P3019
    Urocortin III (human) 357952-09-1 98%
    Urocortin III (human) is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III (human) preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III (human) selectively binds to type 2 CRF receptors with Ki values of 13.5, 21.7, and >100 nM for mCRF2β, rCRF2α, and hCRF1, respectively. Urocortin III (human) mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion.
    Urocortin III (human)
  • HY-P3041
    Chromostatin (bovine) 133633-11-1 98%
    Chromostatin bovine is a chromogranin A (CGA) derivative peptide, which inhibits postassium or carbamoylcholine induced catecholamine release with an ID50 of 5 nM. Chromostatin bovine reduces calcium flux, enhances the desensitization process of the cholinergic-evoked secretory response and modulates the endocrine response associated with catecholamine.
    Chromostatin (bovine)
  • HY-P3056
    GHRF, ovine 94948-82-0 98%
    GHRF, ovine is a growth hormone-releasing factor. GHRF is a specific mediator for the effects of hypoglycemia upon the release of pituitary growth hormone (GH).
    GHRF, ovine
  • HY-P3084
    Human follicular gonadotropin releasing peptide 107873-08-5 98%
    Human follicular gonadotropin releasing peptide (hF-GRP) is a hormone peptide. Human follicular gonadotropin releasing peptide can stimulate pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion in vitro.
    Human follicular gonadotropin releasing peptide
  • HY-P3206
    Serum thymic factor 63958-90-7 98.09%
    Serum thymic factor (Thymulin) is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases.
    Serum thymic factor
  • HY-P3216
    Oxytocin free acid 4248-64-0 98%
    Oxytocin free acid (9-Deamidooxytocin) is an analog of oxytocin in which the glycinamide residue at position 9 in oxytocin has been replaced by a glycine residue. Oxytocin is a pleiotropic, peptide hormone with broad implications for general health, adaptation, development, reproduction, and social behavior.
    Oxytocin free acid
  • HY-P3220
    [D-Asn5]-Oxytocin 5754-53-0 98%
    [D-Asn5]-Oxytocin possesses very low specific oxytocic and vasodepressor activities. By cumulative dose-response studies for oxytocic activity, [D-Asn5]-Oxytocin has similar intrinsic activity to oxytocin.
    [D-Asn5]-Oxytocin
  • HY-P3232
    B 9430 180981-09-3 98%
    B 9430 is a potent bradykinin B1/B2 receptor antagonist.
    B 9430
  • HY-P3489
    β-Corticotropin (swine) 12427-33-7 98%
    β-Corticotropin (swine) is a synthetic form of the peptide hormone corticotropin (ACTH). β-Corticotropin stimulates steroid release.
    β-Corticotropin (swine)
Cat. No. Product Name / Synonyms Application Reactivity