1. Endocrinology

Endocrinology

Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-U00283
    Falintolol, (Z)- 106401-52-9
    Falintolol, (Z)-, a new β-adrenergic antagonist, is characterized by the presence of an oxime function.
    Falintolol, (Z)-
  • HY-U00289
    Opigolix 912587-25-8
    Opigolix (ASP-1707) is a Gonadotropin-releasing hormone (GnRH) receptor antagonist, used for the research of endometriosis and rheumatoid arthritis.
    Opigolix
  • HY-U00293
    ZK-90055 hydrochloride 84638-81-3
    ZK-90055 hydrochloride is a β2 adrenergic receptor agonist.
    ZK-90055 hydrochloride
  • HY-U00313
    Tropodifene 15790-02-0
    Tropodifene (Tropaphen) is an α-Adrenergic receptor inhibitor.
    Tropodifene
  • HY-U00320
    Neurokinin antagonist 1 214487-45-3
    Neurokinin antagonist 1 is a Neurokinin antagonist extracted from patent WO1998045262A1.
    Neurokinin antagonist 1
  • HY-U00323
    Carbazole derivative 1 164914-28-7
    Carbazole derivative 1 is a carbazole derivative which can be used to reduce androgen or oestrogen levels in mammals, including humans.
    Carbazole derivative 1
  • HY-U00333
    α1 adrenoceptor-MO-1 161905-64-2
    α1 adrenoceptor-MO-1, an S enantiomer, has affinity at alpha 1 adrenergic receptor, shows alphalytic activity, and possesses analgesic action; more active than R enantiomer.
    α1 adrenoceptor-MO-1
  • HY-U00335
    FR252384 447405-11-0
    FR252384 is a neuropeptide Y-Y5 receptor antagonist, with an IC50 of 2.3 nM.
    FR252384
  • HY-U00339
    H3 receptor-MO-1 1240914-03-7
    H3 receptor-MO-1 is a modulator of histamine H3 receptor.
    H3 receptor-MO-1
  • HY-U00353
    MCHR1 antagonist 1 391610-37-0
    MCHR1 antagonist 1 is a selective antagonist of melanin concentrating hormone-1 (MCH1) receptor, with a Kb of 1 nM and a Ki of 4 nM at human MCH1, and may be used to reduce the body mass.
    MCHR1 antagonist 1
  • HY-U00355
    YM158 free base 179102-65-9
    YM158 free base is a potent and selective LTD4 and TXA2 receptor antagonist with pA2 values of about 8.87 and 8.81, respectively.
    YM158 free base
  • HY-U00356
    Tertatolol 83688-84-0
    Tertatolol is a potent antagonist of beta-adrenoceptor and 5-HT receptor, with unique renal vasodilatatory effects.
    Tertatolol
  • HY-U00364
    CI-949 104961-19-5
    CI-949 is an allergic mediator release inhibitor, which inhibits histamine, leukotriene C4/D4 (LTC4/LTD4), and thromboxane B2 (TXB2) release with IC50s of 11.4 μM, 0.5 μM and 0.1 μM, respectively.
    CI-949
  • HY-U00365
    5-HT2 antagonist 1 191592-09-3
    5-HT2 antagonist 1 is a potent antagonist of 5-HT2 receptor, with weak α1 adrenoceptor blocking activity.
    5-HT2 antagonist 1
  • HY-U00367
    (4E)-SUN9221 222318-55-0
    (4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.
    (4E)-SUN9221
  • HY-U00371
    AR-08 226081-74-9
    AR-​08 is an agonist of α2-adrenergic receptor, used for the treatment of attention deficit hyperactivety disorder (ADHD).
    AR-08
  • HY-U00375
    Gastrin/CCK antagonist 1 162271-52-5
    Gastrin/CCK antagonist 1 is an antagonist of gastrin/CCK, used for the research of gastrointestinal disorders.
    Gastrin/CCK antagonist 1
  • HY-U00386
    Bometolol Hydrochloride 65023-16-7
    Bometolol Hydrochloride is a beta-adrenergic blocking agent, used for the research of cardiovascular disease.
    Bometolol Hydrochloride
  • HY-U00387
    CCK-A receptor inhibitor 1 137004-80-9
    CCK-A receptor inhibitor 1 is a cholecystokinin A (CCK-A) receptor inhibitor with a binging IC50 of 340 nM.
    CCK-A receptor inhibitor 1
  • HY-U00391
    β3-AR agonist 2 340757-05-3
    β3-AR agonist 2 is a potent and selective β3-adrenergic receptor (β3-AR) agonist with an EC50 of 8 nM.
    β3-AR agonist 2
Cat. No. Product Name / Synonyms Application Reactivity