2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W779504
    b-Cortolone 667-66-3
    b-Cortolone is the metabolite of Cortisol (HY-N0583), that reveals relatively low biological activity.
    b-Cortolone
  • HY-W780779
    (Z)-12-Nonadecen-9-one 63408-45-7
    (Z)-12-Nonadecen-9-one is a sex pheromone attractive to male raspberry bud moths (Heterocrossa rubophaga).
    (Z)-12-Nonadecen-9-one
  • HY-W780784
    (Z,Z)-3,13-Octadecadien-1-ol 66410-24-0
    (Z,Z)-3,13-Octadecadien-1-ol is an insect sex pheromone used for trapping redwood resin borers (Synanthedon sequoiae (Edwards)).
    (Z,Z)-3,13-Octadecadien-1-ol
  • HY-W780787
    (E,Z)-3,13-Octadecadienyl acetate 53120-26-6
    (E,Z)-3,13-Octadecadienyl acetate (E3,Z13-18:Ac) is an insect sex pheromone that elicits attraction in male lesser peachtree borers (Lesser Peachtree Borer), which can be isolated from female lesser peachtree borers.
    (E,Z)-3,13-Octadecadienyl acetate
  • HY-W780803
    (Z,E)-9,12-Tetradecadienol 42521-46-0
    (Z,E)-9,12-Tetradecadienol is a synthetic enhancer of male Ephestia cautella attraction.
    (Z,E)-9,12-Tetradecadienol
  • HY-W780808
    (E)-10-Dodecenol 35237-63-9
    (E)-10-Dodecenol is a sex pheromone capable of eliciting electroantennographic responses in male pea moths.
    (E)-10-Dodecenol
  • HY-W780813
    (Z)-3-Decenol 10340-22-4
    (Z)-3-Decenol is an insect sex pheromone that specifically attracts male beetles.
    (Z)-3-Decenol
  • HY-100607AR
    Landiolol hydrochloride (Standard) 144481-98-1
    Landiolol (ONO1101) hydrochloride (Standard) is the analytical standard of Landiolol hydrochloride (HY-100607A). This product is intended for research and analytical applications. Landiolol (ONO1101) hydrochloride is a highly selective, ultra-short-acting competitive inhibitor of β1 adrenergic receptors. Landiolol hydrochloride specifically blocks cardiac β1 receptors, reducing heart rate and myocardial oxygen consumption. Landiolol hydrochloride inhibits TNF-α-induced excessive mitochondrial oxygen consumption and reactive oxygen species production in a sepsis model, alleviating renal injury. Landiolol hydrochloride has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current) and has a weak negative inotropic effect. Landiolol hydrochloride can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury.
    Landiolol hydrochloride (Standard)
  • HY-100973AR
    Adenosine 5′-diphosphoribose sodium (Standard) 68414-18-6
    Adenosine 5′-diphosphoribose (sodium) (Standard) is the analytical standard of Adenosine 5′-diphosphoribose (sodium). This product is intended for research and analytical applications. Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy.
    Adenosine 5′-diphosphoribose sodium (Standard)
  • HY-101355AR
    CGP 20712 dihydrochloride (Standard) 1216905-73-5
    CGP 20712 (dihydrochloride) (Standard) is the analytical standard of CGP 20712 (dihydrochloride). This product is intended for research and analytical applications. CGP 20712 dihydrochloride is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 dihydrochloride exhibits ~10,000-fold selectivity over β2-adrenoceptors.
    CGP 20712 dihydrochloride (Standard)
  • HY-105124AR
    Bufuralol hydrochloride (Standard) 60398-91-6
    Bufuralol (hydrochloride) (Standard) is the analytical standard of Bufuralol (hydrochloride). This product is intended for research and analytical applications. Bufuralol (Ro 3-4787) hydrochloride is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate.
    Bufuralol hydrochloride (Standard)
  • HY-105634AR
    Nomegestrol acetate (Standard) 58652-20-3
    Nomegestrol acetate (Standard) is the analytical standard of Nomegestrol acetate. This product is intended for research and analytical applications. Nomegestrol acetate is an orally active, highly selective progestogen and a progesterone receptor complete agonist. Nomegestrol acetate inhibits ovulation. Nomegestrol acetate is also effective in inhibiting the proliferation of human endometrial cancer RL95-2 cells in vitro and in vivo. Nomegestrol acetate can be used in cancer (especially endometrial cancer) and contraceptive studies.
    Nomegestrol acetate (Standard)
  • HY-106827S1
    Trimegestone-13C,d3
    Trimegestone-13C,d3 is 13C and deuterated labeled Trimegestone (HY-106827). Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes.
    Trimegestone-13C,d3
  • HY-118830S1
    13,14-Dihydro-15-keto prostaglandin D2-d9 2738376-77-5
    13,14-Dihydro-15-keto prostaglandin D2-d9 (DK-PGD2-d9) is deuterium labeled 13,14-Dihydro-15-keto prostaglandin D2. 13, 14-Dihydro-15-keto prostaglandin D2 (DK-PGD2) is a PGD2 metabolite formed by the 15-hydroxyl PGDH pathway. 13, 14-Dihydro-15-keto prostaglandin D2 is a selective agonist for the DP2 receptor. 13, 14-Dihydro-15-keto prostaglandin D2 can inhibit ion flux in canine colonic mucosa preparation.
    13,14-Dihydro-15-keto prostaglandin D2-d9
  • HY-136435S1
    Mapenterol-d6 hydrochloride 1246816-02-3
    Mapenterol-d6 (hydrochloride) is the deuterium labeled Mapenterol hydrochloride. Mapenterol hydrochloride is a type of β2-adrenoceptor agonist[1][2].
    Mapenterol-d6 hydrochloride
  • HY-17503AS1
    Metoprolol-d6 succinate
    Metoprolol-d6 (succinate) is deuterium labeled Metoprolol (succinate). Metoprolol succinate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties.
    Metoprolol-d6 succinate
  • HY-A0070AS3
    Liothyronine-d3
    Liothyronine-d3 is deuterated labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
    Liothyronine-d3
  • HY-B0192S3A
    Alfuzosin hydrochloride-d6 1006717-24-3
    Alfuzosin (hydrochloride)-d6 (SL 77499-10-d6) is deuterium labeled Alfuzosin (hydrochloride). Alfuzosin (SL 77499-10) hydrochloride is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin hydrochloride relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin hydrochloride can be used in study of benign prostatic hyperplasia (BPH).
    Alfuzosin hydrochloride-d6
  • HY-B0203BS1
    (rac)-Nebivolol-d4 1219407-55-2
    (rac)-Nebivolol-d4 is a labelled racemic Nebivolol. Nebivolol selectively inhibits β1- adrenergic receptor with IC50 of 0.8 nM[1][2].
    (rac)-Nebivolol-d4
  • HY-B1617AS2
    Zuclomiphene d10 Citrate salt
    Zuclomiphene d10 Citrate salt is deuterium labeled Zuclomiphene (citrate). Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent.
    Zuclomiphene d10 Citrate salt
Cat. No. Product Name / Synonyms Application Reactivity