2. Endocrinology

Endocrinology

Endocrinology

Related Products

PDF 21.44 MB

Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-136818
    DA 4643 dihydrochloride 95833-19-5 98%
    DA 4643 (hydrochloride) is an H2 receptor antagonist with the chemical name 2-guanidino-4 (3-methylaminomethyleneiminophenyl) thiazole dihydrochloride. It has a weak interaction with cytochrome P-450 and has a less inhibitory effect on P-450 than cimetidine and tiotidine. DA 4643 (hydrochloride) is able to inhibit both enzymatic and non-enzymatic lipid peroxidation reactions. This inhibition may not be achieved by inhibiting agent metabolizing enzymes, but rather due to the antioxidant properties of the compound itself. Compared with other H2 receptor antagonists such as cimetidine, ranitidine and tiotidine, DA 4643 (hydrochloride) shows a unique effect in lipid peroxidation inhibition. These properties make DA 4643 (hydrochloride) a potential H2 receptor antagonist with multiple mechanisms of action.
    DA 4643 dihydrochloride
  • HY-136935
    Alloyohimbine 522-94-1 98%
    Alloyohimbine, an alkaloid, is a selective α2-adrenoceptor antagonist with K Dα1, K Dα2 of 0.28 μM and 0.006 μM, respectively.
    Alloyohimbine
  • HY-13713A
    LY-377604 hydrochloride 204592-97-2 98%
    LY377604 hydrochloride is a human β3-adrenergic receptor agonist with an EC50 of 2.4 nM and also a β1- and β2-adrenergic receptor antagonist.
    LY-377604 hydrochloride
  • HY-137270
    16,16-Dimethyl PGA2 41691-92-3 98%
    16,16-Dimethyl PGA2 is an orally active prostaglandin analog with a prolonged in vivo half-life. 16,16-Dimethyl PGA2 can be used to study hypertension.
    16,16-Dimethyl PGA2
  • HY-137412
    PGF2α 1,15-lactone 55314-49-3 98%
    PGF2α 1,15-lactone (Prostaglandin F2α 1,15-lactone) is a lipid-soluble internal ester of PGF2α. PGF2α 1,15-lactone decreases menstrual cycle lengths in non-pregnant rhesus monkeys. PGF2α 1,15-lactone terminates early pregnancy in the monkey.
    PGF2α 1,15-lactone
  • HY-137414
    20-Hydroxy Prostaglandin E2 57930-95-7 98%
    20-Hydroxy Prostaglandin E2 (20-Hydroxy-PGE2) is a metabolite of Prostaglandin E2 (HY-101952) that can be metabolized by cytochrome P450.
    20-Hydroxy Prostaglandin E2
  • HY-137444
    Ludaterone 124548-08-9 98%
    Ludaterone is an antiandrogen agent, with potent antiandrogenic activity.
    Ludaterone
  • HY-137483
    Prostaglandin D2 serinol amide 851761-42-7 98%
    Prostaglandin D2 serinol amide is a weak inhibitor of the hydrolysis of [3H]2-oleoylglycerol.
    Prostaglandin D2 serinol amide
  • HY-137585
    17-Trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α 294856-01-2 98%
    17-Trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α is a derivative of Bimatoprost acid (HY-125774).
    17-Trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
  • HY-137591
    13,14-Dihydro-15-keto-PGE1 5094-14-4 98%
    13,14-Dihydro-15-keto-PGE1 is an inactive metabolite of PGE1. 13, 14-Dihydro-15-Keto-pGE1 inhibited platelet aggregation in ADP-induced human isolated platelet-rich plasma with IC50 14.8 μg/mL.
    13,14-Dihydro-15-keto-PGE1
  • HY-138151
    3'-Hydroxy stanozolol 125709-39-9 98%
    3'-Hydroxy stanozolol is a major metabolite of the anabolic androgenic steroid Stanozolol.
    3'-Hydroxy stanozolol
  • HY-138211
    BE-26263 147716-81-2 98%
    BE-26263, an antiosteoporotic agent that can be isolated from Scedosporium apiospermum, possesses estrogenic effect.
    BE-26263
  • HY-138690
    Estrogen receptor modulator 6 787621-78-7 98%
    Estrogen receptor modulator 6 (compound 3a) is a selective estrogen receptor (ER) β agonist (Ki=0.44 nM). Estrogen receptor modulator 6 displays 19-fold selectivity for ERβ over ERα(Ki=8.4 nM).
    Estrogen receptor modulator 6
  • HY-139121
    15(R)-17-Phenyl trinor Prostaglandin F2α 41639-71-8 98%
    15(R)-17-Phenyl trinor Prostaglandin F2α (15-epi Bimatoprost free acid) is a prostaglandin F (FP) analog that acts as an ocular hypotensive agent. The free acid 17-Phenyl trinor Prostaglandin F2α is a potent FP receptor agonist. 15(R)-17-Phenyl trinor Prostaglandin F2α is the 15-epi or "unnatural" isomer of this active free acid metabolite and has reduced FP receptor agonist activity.
    15(R)-17-Phenyl trinor Prostaglandin F2α
  • HY-13955R
    Telmisartan (Standard) 144701-48-4
    Telmisartan (Standard) is the analytical standard of Telmisartan. This product is intended for research and analytical applications. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
    Telmisartan (Standard)
  • HY-139888
    Plasma kallikrein-IN-1 2691030-28-9 98%
    Plasma kallikrein-IN-1 is a PKK inhibitor with an IC50 value of 0.5 nM.
    Plasma kallikrein-IN-1
  • HY-139970
    VPC-13789 2761146-51-2 98%
    VPC-13789 is a potent, selective, and orally bioavailable antiandrogen. VPC-13789 can be used for the research of castration-resistant prostate cancer (CRPC) therapeutics. VPC-13789 inhibits androgen receptor (AR) transcriptional activity in LNCaP cells (IC50=0.19 μM).
    VPC-13789
  • HY-142129
    Pyrocholecalciferol 10346-43-7 98%
    Pyrocholecalciferol, a vitamin D analogue, produced by photochemical transformation of 7-dehydrocholesterol (7-DHC).
    Pyrocholecalciferol
  • HY-142853
    Carbonic anhydrase inhibitor 3 2758231-56-8 98%
    Carbonic anhydrase inhibitor 3 (compound 11g) is a carbonic anhydrase II inhibitor. Carbonic anhydrase inhibitor 3 reduces the intraocular pressure in glaucomatous rabbits.
    Carbonic anhydrase inhibitor 3
  • HY-14299D
    Indacaterol acetate 1000160-96-2 98%
    Indacaterol acetate is an orally active ultra-long-acting β2 adrenergic receptor (ADRB2) agonist. Indacaterol acetate inhibits NF-κB activity in a β-arrestin2-dependent manner, preventing further lung damage and improving lung function in COPD (chronic obstructive pulmonary disorder). Indacaterol acetate can also be used in cardiovascular disease research.
    Indacaterol acetate
Cat. No. Product Name / Synonyms Application Reactivity