2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-13004R
    Maraviroc (Standard) 376348-65-1 98%
    Maraviroc (Standard) is the analytical standard of Maraviroc. This product is intended for research and analytical applications. Maraviroc (UK-427857) is a selective CCR5 antagonist with activity against human HIV.
    Maraviroc (Standard)
  • HY-13004S
    Maraviroc-d6 1033699-22-7 98%
    Maraviroc-d6 (UK-427857-d6) is the deuterium labeled Maraviroc. Maraviroc (UK-427857) is a selective CCR5 antagonist with activity against human HIV.
    Maraviroc-d6
  • HY-130139
    11,12-DiHETE 867350-92-3 98%
    11,12-DiHETE is an orally active metabolite produced by cytochrome p450 mediated epoxide formation and subsequent epoxide hydrolase production.
    11,12-DiHETE
  • HY-130226
    11-epi-PGE1 24570-01-2 98%
    11-epi-PGE1 (11β-Prostaglandin E1) is a less potent isomer of Prostaglandin E1 (HY-B0131). Prostaglandin E1 is a prostanoid receptor ligand.
    11-epi-PGE1
  • HY-130395
    15-Keto latanoprost 135646-98-9 98%
    15-Keto latanoprost is a metabolite of Latanoprost, which is an ocular hypotensive agent.
    15-Keto latanoprost
  • HY-131206
    DS37571084 2460353-87-9 98%
    DS37571084 is an orally active and potent antagonist of the parathyroid hormone type 1 receptor (PTHR1), with an IC50 value of 0.17 μM. DS37571084 can be used for the study of hyperparathyroidism.
    DS37571084
  • HY-131283
    8-Demethyl Ivabradine 304464-97-9 98%
    8-Demethyl Ivabradine is a metabolite of Ivabradine. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker.
    8-Demethyl Ivabradine
  • HY-131586
    3,7-Dihydroxyflavone 492-00-2 98.04%
    3,7-Dihydroxyflavone (Resogalangin) is a flavonoid phytoestrogen, which can be isolated from Adenophora species. 3,7-Dihydroxyflavone is a modulator of estrogen receptors and an inhibitor of human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase and a redox inhibitor (IC50=0.6 and 6.0 μM, respectively). 3,7-Dihydroxyflavone is a fluorescent binding substrate for human serum albumin (HSA) with excitation wavelengths of 370 nm (pH 7.4) and 350 nm (pH 3.5), respectively, and emission wavelength of 515 nm.
    3,7-Dihydroxyflavone
  • HY-131921
    DL-Glyceraldehyde 3-phosphate diethyl acetal barium 93965-35-6 98%
    DL-Glyceraldehyde 3-phosphate diethyl acetal barium is an Aspartate Aminotransferase isozyme inhibitor.
    DL-Glyceraldehyde 3-phosphate diethyl acetal barium
  • HY-131946
    Menotropin 61489-71-2 98%
    Menotropin (Menotrophin) is a hormone that can be extracted from the urine of postmenopausal women and has both follicle stimulating hormone (FSH) and luteinizing hormone (LH) activity.
    Menotropin
  • HY-132277
    15-Keto Bimatoprost 1163135-96-3 98%
    15-Keto Bimatoprost is a prostaglandin F2α (PGF2α) analog that can be used for the research of ocular hypotensive.
    15-Keto Bimatoprost
  • HY-13245A
    (s)-PF-4136309 1372407-07-2 98.93%
    (s)-PF-4136309 is the isomer of PF-4136309 (HY-13245), and can be used as an experimental control. PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.
    (s)-PF-4136309
  • HY-13284S
    7-α-Methylthio Spironolactone-d3 98%
    7-α-Methylthio Spironolactone-d3 is the deuterium labeled 7-α-Methylthio Spironolactone.
    7-α-Methylthio Spironolactone-d3
  • HY-133189
    Bis-propargyl-PEG9 1351373-47-1
    Bis-propargyl-PEG9 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG9 can be used to synthesize the bivalent estrogen receptor ligands. Bis-propargyl-PEG9 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG9
  • HY-133949
    8,11-Eicosadiynoic acid 82073-91-4 98%
    8,11-Eicosadiynoic acid, an unsaturated fatty acid, is a steroid 5α-reductase inhibitor. 8,11-Eicosadiynoic acid can be used for the research of acne.
    8,11-Eicosadiynoic acid
  • HY-134462
    RJW103 1276664-14-2 98%
    RJW103 is a selective steroidogenic factor-1 (SF-1, NR5A1) agonist with a pEC50 of 6.5. RJW103 shows a pEC50 of 5.9 for liver receptor homologue-1 (LRH-1, NR5A2). RJW103 can be used for the researches of cancer, endocrinology and metabolic disease, such as adrenal cortex neoplasms.
    RJW103
  • HY-135242
    LY87130 free base 72877-72-6 98%
    LY87130 free base is an octopamine-N-methyltransferase inhibitor with epinephrine-inhibiting activity. LY87130 free base can significantly reduce the basal level of epinephrine in the hypothalamus after administration. LY87130 free base has no significant effect on the basal levels of norepinephrine, 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) in the hypothalamus.
    LY87130 free base
  • HY-135446
    BQ-610 141595-53-1 98%
    BQ-610 is a selective antagonist of the endothelin A receptor (ETA receptor). BQ-610 specifically blocks the ETA receptor, competitively inhibiting the binding of endothelin-1 (ET-1) (a vasoconstrictive peptide) to the receptor, thereby blocking the effects of ET-1 such as vascular smooth muscle contraction, cell mitosis, and inhibition of hormone secretion. BQ-610 significantly alleviates cerebral vasospasm in rabbits. BQ-610 blocks the bronchial epithelial and pulmonary vascular cell proliferation caused by cigarette smoke in rat models. BQ-610 can delay the natural luteal regression in the cow's uterus. BQ-610 can be used for research on vasospasm, abnormal cell proliferation, and reproductive endocrine disorders.
    BQ-610
  • HY-135473
    Chlormadinone 1961-77-9 98.09%
    Chlormadinone is an antiandrogen agent. Chlormadinone can be used for the study of benign prostatic hyperplasia (BPH).
    Chlormadinone
  • HY-135500
    ACT-373898 1433875-14-9 98%
    ACT-373898 is an inactive carboxylic acid metabolite of Macitentan. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin receptor) antagonist.
    ACT-373898
Cat. No. Product Name / Synonyms Application Reactivity