2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-158264
    SNRI-IN-1 887766-95-2 98%
    SNRI-IN-1 (Compound 7a) is a dual serotonin and noradrenaline monoamine reuptake inhibitor, P-glycoprotein Efflux Ratio is 20.
    SNRI-IN-1
  • HY-158311
    Anti-osteoporosis agent-8 3036050-96-8 98%
    Anti-osteoporosis agent-8 (Compound 4aa) is an inhibitor for RANKL, which inhibits RANKL-induced osteoclastogenesis and osteoclast differentiation (IC50 is 2.41 μM) in cells RAW264.7. Anti-osteoporosis agent-8 ameliorates bone loss in an ovariectomized (OVX) mice model.
    Anti-osteoporosis agent-8
  • HY-159621
    Endosidine 5 364361-68-2 98%
    Endosidine 5 (ES5) inhibits EPS (extracellular polymeric substance) secretion and cell wall expansion. Endosidine 5 alters secretion of ECM (extracellular matrix) material in Penium margaritaceum by affecting the Golgi apparatus. Endosidine 5 interferes with recycling endosomes through Annexin A6, thereby promoting the release and expression of mRNA into the cytoplasm.
    Endosidine 5
  • HY-160659
    Androgen receptor antagonist 10 876759-87-4 98%
    Androgen receptor antagonist 10 (compound 6h) is a androgen receptor antagonist. Androgen receptor antagonist 10 reduces the wax esters in the golden syrian hamster model.
    Androgen receptor antagonist 10
  • HY-160680
    AR antagonist 6 876760-08-6 98%
    AR antagonist 6 (compound 6i) is a diphenyl ether androgen receptor (AR) antagonist that binds AR at a concentration of 120 nM. AR antagonist 6 exhibits low toxicity and in vitro activity against the golden Syrian hamster ear model.
    AR antagonist 6
  • HY-160856
    TOP5300 1848981-48-5 98%
    TOP5300 is an orally active follicle-stimulating hormone receptor allosteric agonist. TOP5300 can induce the production of testosterone in stromal cells and promote follicular genesis and superovulation in rats.
    TOP5300
  • HY-160857
    TOP5668 1850256-71-1 98%
    TOP5668 is an orally active follicle-stimulating hormone receptor allosteric agonist. TOP5668 can induce the production of testosterone in stromal cells and promote follicular genesis and superovulation in rats.
    TOP5668
  • HY-160979
    Bisfentidine 96153-56-9 98%
    Bisfentidine is an H2 receptor antagonist, Bisfentidine can block the H2 receptor on the cells of the stomach wall, and reduce the secretion of stomach acid. Bisfentidine binds to cytochrome P-450 in liver microsomes and affects drug metabolism. Bisfentidine can be used in the study of metabolic processes of drugs, lipid peroxidation processes and peptic ulcers diseases.
    Bisfentidine
  • HY-160984
    Rotraxate 92071-51-7 98%
    Rotraxate (TEI 5103) is an orally active anti-ulcer compound. Rotraxate can increase blood flow to the gastric mucosa and promote the integrity of the gastric mucosa. Rotraxate can be used to study the protective effects of drugs on the gastric mucosa, especially in investigating how drugs can prevent or treat gastric ulcers by acting directly on the gastric mucosa.
    Rotraxate
  • HY-161522
    α-Glucosidase-IN-63 2375866-82-1 98%
    α-Glucosidase-IN-63 (Compound 4d) is an inhibitor of α-Glucosidase (IC50=0.44 μM). α-Glucosidase-IN-63 inhibits hCA II with an activity of Ki= 7.0 nM. α-Glucosidase-IN-63 is orally effective..
    α-Glucosidase-IN-63
  • HY-16171R
    Diphenmanil methylsulfate (Standard) 62-97-5
    Diphenmanil (methylsulfate) (Standard) is the analytical standard of Diphenmanil (methylsulfate). This product is intended for research and analytical applications. 0
    Diphenmanil methylsulfate (Standard)
  • HY-162105
    Aromatase-IN-3 98%
    Aromatase-IN-3 (compound 7d) is an aromatase inhibitor with an IC50 of 54 nM. Through suppressing the conversion of androstenedione to oestrogen caused by aromatase, Aromatase-IN-3 exerts an appreciable tumor growth inhibitory activities against breast cancer cell lines, suggesting its usage for ER+ cancer research.
    Aromatase-IN-3
  • HY-162390
    α-Amylase/α-Glucosidase-IN-11 98%
    α-Amylase/α-Glucosidase-IN-11 (Compound 5d) is a isoxazolidine-isatin hybrid with significant antidiabetic activity. α-Amylase/α-Glucosidase-IN-11 competitively inhibits α-amylase (IC50 = 30.39 μM) and α-glucosidase (IC50 = 65.1 μM), two key digestive enzymes. α-Amylase/α-Glucosidase-IN-11 does not cross the blood-brain barrier.
    α-Amylase/α-Glucosidase-IN-11
  • HY-162427
    NMS-0963 2765304-82-1 98%
    NMS-0963 (compound 1) is an inhibitor of spleen tyrosine kinase (SYK) with an oral activity and IC50 value of 3 nM. NMS-0963 inhibits BaF3-TEL/SYK cell line proliferative at 27 nM.
    NMS-0963
  • HY-162480
    PTP1B-IN-27 98%
    PTP1B-IN-27 (Compound 7i) is an inhibitor of protein tyrosine phosphatase 1-B (PTP‐1B)(IC50=8.2 µM). PTP1B-IN-27 also inhibits α-Glucosidase (IC50=120 µM) and shows competitive inhibition (Ki=118 µM).
    PTP1B-IN-27
  • HY-162547
    Oxogestone phenpropionate 16915-80-3 98%
    Oxogestone phenpropionate is a progesterone that can be used in studies to regulate hormone levels.
    Oxogestone phenpropionate
  • HY-163373
    13,14-Dihydro-15-keto prostaglandin D1 1392219-79-2 98%
    13,14-Dihydro-15-keto prostaglandin D1 is a derivative of prostaglandin D1.
    13,14-Dihydro-15-keto prostaglandin D1
  • HY-163485
    AR antagonist 8 98%
    AR antagonist 8 (compound 16), an unnatural entestrane, is a potent Lupeol-inspired androgen receptor (AR) antagonist with an IC50 of 0.76 μM.
    AR antagonist 8
  • HY-164034
    Ganglefene 299-61-6 98%
    Ganglefene is a blocker for n-choline receptor, which leads to the sexual dysfunction in the offspring in adulthood, when administrated to pregnant rats.
    Ganglefene
  • HY-16474S
    Relugolix-d6 98%
    Relugolix-d6 is deuterium labeled Relugolix. Relugolix (TAK-385)?is a potent, orally active, nonpeptidic gonadotropin-releasing hormone (GnRH) antagonist. Relugolix possesses high affinity and potent antagonistic activity for human receptor (binding IC50=0.33 nM) and monkey receptor (IC50=0.32 nM) compared with TAK-013 (HY-100209). Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al.
    Relugolix-d6
Cat. No. Product Name / Synonyms Application Reactivity