2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-118772
    17-Phenyl trinor prostaglandin A2 38315-51-4 98%
    17-Phenyl trinor prostaglandin A2 is a synthetic prostaglandin analog.
    17-Phenyl trinor prostaglandin A2
  • HY-118950
    J 628 65323-80-0 98%
    J 628 is an estrogen derivative used to study antifertility effects after sexual intercourse in mice, rats, and rabbits.
    J 628
  • HY-118978
    PF-00277343 332926-04-2 98%
    PF-00277343 is a selective and skin-penetrable THR-β (Ki: 0.51 nM for THR-β, 8.0 nM for THR-α) agonist. PF-00277343 is effective against androgenetic alopecia in animal models.
    PF-00277343
  • HY-119006
    L-640,033 115326-36-8 98%
    L-640,033 is a potent agonist of β-adrenergic. L-640,033 play an important role in lipid metabolism, and growth.
    L-640,033
  • HY-119095
    L-741671 187724-85-2 98%
    L-741671 is a selective and brain-permeable antagonist of neurokininl (hNKI) receptor, with Kis of 64 nM, 0.03 nM and 0.7 nM in rat, human and ferret, respectively.
    L-741671
  • HY-119262
    ABT-866 258526-74-8 98%
    ABT-866 is an α1A-adrenoceptor agonist and an antagonist at the α1B- and α1D-adrenoceptor subtypes. ABT-866 has an EC50 of 0.60 μM for the α1A in the rabbit urethra. ABT-866 has a pA2 value of 5.4 for the α1B in the rat spleen. ABT-866 has a pA2 value of 6.2 for the α1D in the rat aorta. ABT-866 exhibits good urethral selectivity and lower cardiovascular side effects in stress urinary incontinence models. ABT-866 can be used for the research of diseases such as stress urinary incontinence.
    ABT-866
  • HY-119332
    3-Keto petromyzonol 359436-56-9 98%
    3-Keto petromyzonol, a main component of Sea lamprey male sex pheromones, modulates both synthesis and release of gonadotropin releasing hormone (GnRH), and subsequently, hypothalamic-pituitary-gonadal (HPG) output in immature sea lamprey.
    3-Keto petromyzonol
  • HY-119539
    Limocitrin 489-33-8 98%
    Limocitrin is a natural product that can be isolated from the buds of P. acerifolia and P. orientalis. Limocitrin suppresses estradiol-dependent proliferation of MCF7 cells weakly but estradiol-induced AlkP (alkaline phosphatase) expression only marginally.
    Limocitrin
  • HY-119611
    Thioquinapiperifil 220060-39-9 98%
    Thioquinapiperifil (KF31327 free base), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study.
    Thioquinapiperifil
  • HY-119615
    Mezilamine 50335-55-2 98%
    Mezilamine is a potent antidopaminergic agent. Mezilamine induces a concentration dependent increase in the electrically stimulated overflow of 3H-noradrenaline from rat cortical slices, without affecting the basal overflow. Mezilamine acts as a presynaptic α-adrenoceptor antagonist and a postsynaptic α-adrenoceptor agonist.
    Mezilamine
  • HY-120029
    Org-9935 129425-83-8 98%
    Org-9935 is a selective inhibitor of PDE3 with an IC50 of 50 nM. Org-9935 inhibits maturation of oocyte in naturally selected dominant follicle in rhesus macaques. Org-9935 can augment glucose-induced insulin release in isolated rat islets with an EC50 of 20 μM.
    Org-9935
  • HY-120067
    YM116 183012-13-7 98%
    YM116 is an orally active and competitive CYP17A1 (17,20-lyase) inhibitor (Ki: 0.38 nM). YM116 reduces the synthesis of adrenal androgens by preferentially inhibiting C17-20 lyase activity. YM116 decreases the serum testosterone concentration, reduces dehydroepiandrosterone sulfate levels and decreases prostatic weights.
    YM116
  • HY-120197
    17-Phenyl trinor prostaglandin F2α methyl amide 155206-01-2 98%
    17-Phenyl trinor prostaglandin F2α methyl amide is a prostaglandin F 2α (PGF 2α) analog that competes with native PGF 2α for receptor binding.
    17-Phenyl trinor prostaglandin F2α methyl amide
  • HY-120285
    M-0002 hydrochloride 285559-03-7 98%
    M-0002 hydrochloride (RWJ-351647 hydrochloride) is a biologically active compound that acts as an antagonist of the vasopressin V2 receptor. M-0002 hydrochloride is potentially useful for inhibiting ascites. M-0002 hydrochloride shows excellent properties that are favorable for clinical development.
    M-0002 hydrochloride
  • HY-120287
    L-054522 214348-67-1 98%
    L-054522 is an agonist for somatostatin receptor subtype 2 with Kd of 0.01 nM. L-054522 inhibits growth hormone release from rat primary pituitary cell (IC50=0.05 nM) and glucagon and insulin release from isolated mouse pancreatic islet cell (IC50=0.05 nM and 12 nM).
    L-054522
  • HY-120301
    L-366682 127819-96-9 98%
    L-366682, a cyclic hexapeptide, possesses antagonism of oxytocin.
    L-366682
  • HY-120398
    CH5447240 1253919-92-4 98%
    CH5447240 is an agonist for parathyroid hormone receptor 1 (PTHR1), that inhibits human PTHR1 with an EC50 of 12 μM. CH5447240 exhibits good metabolic stability in human liver microsomes. CH5447240 increases serum calcium levels in rats. CH5447240 can be used in research about hypoparathyroidism.
    CH5447240
  • HY-120473
    TAK-259 1192348-73-4 98%
    TAK-259 is an orally active and selective α1D adrenoceptor (α1D-AR) antagonist with a Ki value of 1.1 nM. TAK-259 inhibits excessive contraction of bladder smooth muscle and prolongs voiding intervals. TAK-259 is promising for research of urinary system diseases.
    TAK-259
  • HY-120665
    Prostaglandin B1 13345-51-2 98%
    Prostaglandin B1 (PGB1) is a metabolite of Prostaglandin E1 (HY-B0131). Prostaglandin E1 is a prostanoid receptor ligand.
    Prostaglandin B1
  • HY-120703
    RU 58642 143782-63-2 98%
    RU 58642 is an orally active non-steroidal antiandrogen, which displays a strong and selective affinity for androgen receptor.
    RU 58642
Cat. No. Product Name / Synonyms Application Reactivity