2. Endocrinology

Endocrinology

Endocrinology

Related Products

PDF 21.44 MB

Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-137414
    20-Hydroxy Prostaglandin E2 57930-95-7 98%
    20-Hydroxy Prostaglandin E2 (20-Hydroxy-PGE2) is a metabolite of Prostaglandin E2 (HY-101952) that can be metabolized by cytochrome P450.
    20-Hydroxy Prostaglandin E2
  • HY-137444
    Ludaterone 124548-08-9 98%
    Ludaterone is an antiandrogen agent, with potent antiandrogenic activity.
    Ludaterone
  • HY-137483
    Prostaglandin D2 serinol amide 851761-42-7 98%
    Prostaglandin D2 serinol amide is a weak inhibitor of the hydrolysis of [3H]2-oleoylglycerol.
    Prostaglandin D2 serinol amide
  • HY-137585
    17-Trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α 294856-01-2 98%
    17-Trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α is a derivative of Bimatoprost acid (HY-125774).
    17-Trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
  • HY-137591
    13,14-Dihydro-15-keto-PGE1 5094-14-4 98%
    13,14-Dihydro-15-keto-PGE1 is an inactive metabolite of PGE1. 13, 14-Dihydro-15-Keto-pGE1 inhibited platelet aggregation in ADP-induced human isolated platelet-rich plasma with IC50 14.8 μg/mL.
    13,14-Dihydro-15-keto-PGE1
  • HY-138151
    3'-Hydroxy stanozolol 125709-39-9 98%
    3'-Hydroxy stanozolol is a major metabolite of the anabolic androgenic steroid Stanozolol.
    3'-Hydroxy stanozolol
  • HY-138211
    BE-26263 147716-81-2 98%
    BE-26263, an antiosteoporotic agent that can be isolated from Scedosporium apiospermum, possesses estrogenic effect.
    BE-26263
  • HY-138690
    Estrogen receptor modulator 6 787621-78-7 98%
    Estrogen receptor modulator 6 (compound 3a) is a selective estrogen receptor (ER) β agonist (Ki=0.44 nM). Estrogen receptor modulator 6 displays 19-fold selectivity for ERβ over ERα(Ki=8.4 nM).
    Estrogen receptor modulator 6
  • HY-139121
    15(R)-17-Phenyl trinor Prostaglandin F2α 41639-71-8 98%
    15(R)-17-Phenyl trinor Prostaglandin F2α (15-epi Bimatoprost free acid) is a prostaglandin F (FP) analog that acts as an ocular hypotensive agent. The free acid 17-Phenyl trinor Prostaglandin F2α is a potent FP receptor agonist. 15(R)-17-Phenyl trinor Prostaglandin F2α is the 15-epi or "unnatural" isomer of this active free acid metabolite and has reduced FP receptor agonist activity.
    15(R)-17-Phenyl trinor Prostaglandin F2α
  • HY-13955R
    Telmisartan (Standard) 144701-48-4
    Telmisartan (Standard) is the analytical standard of Telmisartan. This product is intended for research and analytical applications. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
    Telmisartan (Standard)
  • HY-139888
    Plasma kallikrein-IN-1 2691030-28-9 98%
    Plasma kallikrein-IN-1 is a PKK inhibitor with an IC50 value of 0.5 nM.
    Plasma kallikrein-IN-1
  • HY-139970
    VPC-13789 2761146-51-2 98%
    VPC-13789 is a potent, selective, and orally bioavailable antiandrogen. VPC-13789 can be used for the research of castration-resistant prostate cancer (CRPC) therapeutics. VPC-13789 inhibits androgen receptor (AR) transcriptional activity in LNCaP cells (IC50=0.19 μM).
    VPC-13789
  • HY-142069
    KB-R7785 168158-16-5 98%
    KB-R7785 is a novel matrix metalloproteinase (MMP) inhibitor, which improves insulin sensitivity by inhibiting TNF-α production. KB-R7785 can be used for diabetes research. KB-R7785 has a protective efficacy against focal cerebral ischemia.
    KB-R7785
  • HY-142129
    Pyrocholecalciferol 10346-43-7 98%
    Pyrocholecalciferol, a vitamin D analogue, produced by photochemical transformation of 7-dehydrocholesterol (7-DHC).
    Pyrocholecalciferol
  • HY-142853
    Carbonic anhydrase inhibitor 3 2758231-56-8 98%
    Carbonic anhydrase inhibitor 3 (compound 11g) is a carbonic anhydrase II inhibitor. Carbonic anhydrase inhibitor 3 reduces the intraocular pressure in glaucomatous rabbits.
    Carbonic anhydrase inhibitor 3
  • HY-14299D
    Indacaterol acetate 1000160-96-2 98%
    Indacaterol acetate is an orally active ultra-long-acting β2 adrenergic receptor (ADRB2) agonist. Indacaterol acetate inhibits NF-κB activity in a β-arrestin2-dependent manner, preventing further lung damage and improving lung function in COPD (chronic obstructive pulmonary disorder). Indacaterol acetate can also be used in cardiovascular disease research.
    Indacaterol acetate
  • HY-14299S
    Indacaterol-d3 2699828-16-3 98%
    Indacaterol-d3 is deuterium labeled Indacaterol.
    Indacaterol-d3
  • HY-143656
    SH379 2338793-00-1 98%
    SH379 is the derivative of 2-methylpyrimidine-fused tricyclic diterpene. SH379 is a potent and orally active anti-late-onset hypogonadism agent. SH379 significantly promotes the expression of the key testosterone synthesis-related enzymes StAR and 3β-HSD. SH379 stimulates autophagy through regulating AMPK/mTOR signaling pathway.
    SH379
  • HY-14369S
    Elagolix-13C,d3 sodium 98%
    Elagolix-13C,d3 (sodium) is the 13C- and deuterium labeled Elagolix sodium. Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively.
    Elagolix-13C,d3 sodium
  • HY-144204
    Estrogen receptor antagonist 5 2136600-69-4 98%
    Estrogen receptor antagonist 5 is a potent antagonist of Estrogen receptor. The estrogen receptor is a ligand-activated transcriptional regulatory protein that mediates induction of a variety of biological effects through its interaction with endogenous estrogens. Estrogen receptor antagonist 5 has the potential for the research of metastatic disease (extracted from patent WO2017174757A1, compound 165).
    Estrogen receptor antagonist 5
Cat. No. Product Name / Synonyms Application Reactivity