2. Endocrinology

Endocrinology

Endocrinology

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Found in most species of the animal kingdom, the endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones. In response to environmental stimuli, the endocrine system secretes hormones and uses them as chemical messengers to orchestrate physiological, developmental and reproductive changes that affect the entire body for a long period of time. In order to maintain the proper functioning of the body through its entire life cycle, the endocrine system utilizes a complex feedback mechanism to fine-tune the balance of hormones in the bloodstream. Even a slight disruption to endocrine system’s function can throw off the delicate balance of hormones in the human body and lead to an endocrine disorder, or endocrine disease, such as diabetes, adrenal insufficiency, hyper- or hypothyroidism, and polycystic ovary syndrome (PCOS).

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-100607
    Landiolol 133242-30-5 98%
    Landiolol (ONO1101) is a highly selective, ultra-short-acting competitive inhibitor of β1 adrenergic receptors. Landiolol specifically blocks cardiac β1 receptors, reducing heart rate and myocardial oxygen consumption. Landiolol inhibits TNF-α-induced excessive mitochondrial oxygen consumption and reactive oxygen species production in a sepsis model, alleviating renal injury. Landiolol has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current) and has a weak negative inotropic effect. Landiolol can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury.
    Landiolol
  • HY-100661
    Cetirizine Impurity D 346451-15-8 98%
    Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response.
    Cetirizine Impurity D
  • HY-100934
    SC-9 102649-78-5 98%
    SC-9 is a PKC activator in the presence of Ca2+.
    SC-9
  • HY-100940
    6-Chloromelatonin 63762-74-3 98%
    6-Chloromelatonin is a potent melatonin receptor agonist with greater metabolic stability than melatonin. 6-Chloromelatonin compete for [3H]-melatonin and 2-[125I]-iodomelatonin binding to MT1 receptors (pKi=8.9 and 9.1, respectively). 6-Chloromelatonin compete for [3H]-melatonin binding to MT2 receptors (pKi=9.77).
    6-Chloromelatonin
  • HY-101038
    ZK 756326 874911-96-3 98%
    ZK756326 is a nonpeptide chemokine receptor agonist for the CC chemokine receptor CCR8.
    ZK 756326
  • HY-101236
    ICI 192605 117621-64-4 98%
    ICI 192605 is a potent TXA2R (thromboxane A2 receptor) antagonist as cell signaling prostaglandin. ICI 192605 blocks contraction of isolated guinea pig trachea induced by U-46619.
    ICI 192605
  • HY-101320
    ZD-7114 129689-30-1 98%
    ZD-7114 is a potent and selective agonist of β3-adrenergic. ZD-7114 is a selective thermogenic agent in vivo. ZD-7114 can be used in study obesity and diabetes.
    ZD-7114
  • HY-101602
    Aligeron 70713-45-0 98%
    Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties.
    Aligeron
  • HY-101606
    Etersalate 62992-61-4 98%
    Etersalate inhibits platelet function and decreases thromboxane A2 (TXA2) levels.
    Etersalate
  • HY-101692
    AZ-1355 75451-07-9 98.19%
    AZ-1355 is an orally active and effctive lipid-lowering agent. AZ-1355 inhibits platelet aggregation in vivo and elevates the prostaglandin I2/thromboxane A2 ratio in vitro.
    AZ-1355
  • HY-101752
    (±)-Befunolol 39552-01-7 98%
    (±)-Befunolol is a β-adrenoceptor blocking agent.
    (±)-Befunolol
  • HY-101822
    Naminterol 93047-40-6 98%
    Naminterol is a phenethanolamine derivative, is a β2 adrenoceptor agonist with bronchodilatory properties. Naminterol is used for treatment of asthma.
    Naminterol
  • HY-103209
    Rec 15/2615 hydrochloride 173059-17-1 98%
    Rec 15/2615 hydrochloride is a potent and selective α-1B adrenoceptor antagonist with Ki values of 1.9 nM, 0.3 nM, 2.6 nM for α1A, α1B, α1D, respectively. Rec 15/2615 hydrochloride modulates vaginal smooth muscle contractility and genital engorgement.
    Rec 15/2615 hydrochloride
  • HY-103296
    Bombinakinin M 509151-65-9 98%
    Bombinakinin M is a bradykinin receptor agonist with contractile activity in the guinea pig ileum.
    Bombinakinin M
  • HY-103379
    CP 376395 hydrochloride 1013933-37-3 98%
    CP 376395 hydrochloride is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist.
    CP 376395 hydrochloride
  • HY-103446
    FERb 033 1111084-78-6 98%
    FERb 033 is a selective and potent ERβ agonist (Ki=7.1 nM, EC50=4.8 nM). FERb 033 shows 62-fold selectivity over ERα.
    FERb 033
  • HY-103452
    RU58668 151555-47-4 98%
    RU58668 is a steroidal antiestrogen that can be used as a potent antiproliferative agent on MCF-7 cells. RU58668 has the potential for the breast cancer research.
    RU58668
  • HY-103453
    (R)-DPN 524047-78-7 98%
    (R)-DPN (compound 3) is a selective ERβ ligand with EC50s of 2.9, 0.8 nM for ERα and ERβ, respectively. (R)-DPN shows a very high affinity and potency preference for ERβ over ERα. (R)-DPN shows cytoxicity for HEC-1 and U2OS cells with EC50s of 286, 205 nM, respectively.
    (R)-DPN
  • HY-103540
    Tabimorelin hemifumarate 242143-80-2 98%
    Tabimorelin (NN703) hemifumarate is an orally active growth hormone (GH) secretagogue. Tabimorelin hemifumarate is also a potent inhibitor of CYP3A4 activity.
    Tabimorelin hemifumarate
  • HY-103649
    OT antagonist 3 925703-75-9 98%
    OT antagonist 3 is an oxytocin (OT) antagonist extracted from patent WO2007017752A1.
    OT antagonist 3
Cat. No. Product Name / Synonyms Application Reactivity