2. Natural Products
  3. Plants
  4. Polygalaceae
  5. Polygala senega L.

Polygala senega L.

Polygala senega L. (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N2099A
    (Z)-Onjisaponin B 162681-53-0
    (Z)-Onjisaponin B ((Z)-Senegin III) is a derivative of Onjisaponin B (HY-N2099). Onjisaponin B is an orally active natural product derived from Polygala tenuifolia. Onjisaponin B inhibits NF-κB p65. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin. Onjisaponin B reduces β-amyloid (Aβ) production. Onjisaponin B reduces radiation-induced cell apoptosis. Onjisaponin B has anti-oxidant and anti-inflammatory activities. Onjisaponin B can be used for neurological disease and radiation injury study, and its metabolite tenuifolin (TF) can enter the brain through the BBB.
    (Z)-Onjisaponin B