2. Apoptosis Metabolic Enzyme/Protease
  3. MDM-2/p53 E1/E2/E3 Enzyme
  4. AM-6761

AM-6761 is a potent MDM2 inhibitor with an IC50 of 0.1 nM.

For research use only. We do not sell to patients.

AM-6761

AM-6761 Chemical Structure

CAS No. : 1584732-36-4

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AM-6761 Related Antibodies

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Description

AM-6761 is a potent MDM2 inhibitor with an IC50 of 0.1 nM.

IC50 & Target

IC50: 0.1 nM (MDM2)[1]
In Vitro

AM-6761 is a potent inhibitor with remarkable biochemical (IC50=0.1 nM) and cellular potency (IC50=16 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AM-6761 Related Antibodies
In Vivo

AM-6761 has favorable pharmacokinetic properties.AM-6761 shows excellent antitumor activity in the SJSA-1 osteosarcoma xenograft model with an ED50 of 11 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

695.69

Formula

C33H37Cl2FN2O5S2
CAS No.
SMILES

O=C(O)CC1=CN=C(C[C@]2(C)C(N([C@@H](C3CC3)CS(=O)(C(C)(C)C)=O)[C@H](C4=CC=C(Cl)C(F)=C4)[C@@H](C5=CC=CC(Cl)=C5)C2)=O)S1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Cell Assay
[1]

HCT116 cells are treated with AM-6761 (0.001-10 μM). The potency of MDM2 inhibitors is determined byBrdU proliferation assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[1]

Mice[1]

SJSA-1 cells (5 × 106) are implanted subcutaneously into female athymic nude mice. Treatment with vehicle or 4 at 5, 12.5, 25, or 50 mg/kg QD AM-6761 by oral gavage begins on day 9 when tumors reach 200 mm3. Tumor sizes and body weights are measured twice per week[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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AM-6761 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM-67611584732-36-4AM6761AM 6761MDM-2/p53E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseInhibitorinhibitorinhibit

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