2. Anti-infection Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR MAPK/ERK Pathway Stem Cell/Wnt
  3. Bacterial VEGFR Akt ERK
  4. 6'-Sialyllactose

6'-Sialyllactose promotes the growth of beneficial bacteria (such as Bifidobacterium and lactobacillus) and inhibits the proliferation of harmful bacteria. 6'-Sialyllactose exhibits anti-inflammatory and anti-angiogenic activities. 6'-Sialyllactose promotes the muscle health.

For research use only. We do not sell to patients.

6'-Sialyllactose Chemical Structure

6'-Sialyllactose Chemical Structure

CAS No. : 35890-39-2

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Based on 1 publication(s) in Google Scholar

Other Forms of 6'-Sialyllactose:

6'-Sialyllactose Related Antibodies

Top Publications Citing Use of Products

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Akt Akt1 Akt2 Akt3

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ERK ERK1 ERK2 ERK5 ERK8

  • Biological Activity

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Description

6'-Sialyllactose promotes the growth of beneficial bacteria (such as Bifidobacterium and lactobacillus) and inhibits the proliferation of harmful bacteria. 6'-Sialyllactose exhibits anti-inflammatory and anti-angiogenic activities. 6'-Sialyllactose promotes the muscle health[1][2][3][4].

In Vitro

6'-Sialyllactose (0-50 μM, 24 h) inhibits Dihydrotestosterone-induced proliferation of HUVECs, suppresses tubular structure formation, inhibits the activation of VEGFR-2-related Akt-ERK signaling pathway[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6'-Sialyllactose Related Antibodies

Western Blot Analysis[4]

Cell Line: HUVEC
Concentration: 0-50 μM
Incubation Time: 24 h
Result: Downregulated levels of p-Akt and p-ERK.
In Vivo

6'-Sialyllactose (5% added to mouse diet, 2 weeks) alleviates the anxiety-like behavior of mice, regulates the flora composition in social disruption (SDR)-stressed mouse model[2].
6'-Sialyllactose (100 mg/kg, po, once daily, 5 times a week for 12 weeks) increases the muscle mass and strength, thereby improving the exercise endurance of mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SDR-stressed mouse model[2]
Dosage: 5% added to mouse diet
Administration: po, 2 weeks
Result: Reduced the anxiety-like behavior in open field tests.
Maintained the number of DCX-positive cells in the hippocampus.
Animal Model: C57BL/6J mouse models[3]
Dosage: 100 mg/kg
Administration: po, once daily, 5 times a week for 12 weeks
Result: Increased the mouse running distance.
Increased the absolute weight of gastrocnemius and soleus muscles.
Molecular Weight

633.55

Formula

C23H39NO19
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]([C@@H]([C@H]([C@H]1O)O)O)O[C@@H]1CO[C@]2(O[C@@]([C@@H]([C@H](C2)O)NC(C)=O)([H])[C@H](O)[C@H](O)CO)C(O)=O
Structure Classification
Initial Source

Clostridium perfringens
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (78.92 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5784 mL 7.8920 mL 15.7841 mL
5 mM 0.3157 mL 1.5784 mL 3.1568 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.5784 mL 7.8920 mL 15.7841 mL 39.4602 mL
5 mM 0.3157 mL 1.5784 mL 3.1568 mL 7.8920 mL
10 mM 0.1578 mL 0.7892 mL 1.5784 mL 3.9460 mL
15 mM 0.1052 mL 0.5261 mL 1.0523 mL 2.6307 mL
20 mM 0.0789 mL 0.3946 mL 0.7892 mL 1.9730 mL
25 mM 0.0631 mL 0.3157 mL 0.6314 mL 1.5784 mL
30 mM 0.0526 mL 0.2631 mL 0.5261 mL 1.3153 mL
40 mM 0.0395 mL 0.1973 mL 0.3946 mL 0.9865 mL
50 mM 0.0316 mL 0.1578 mL 0.3157 mL 0.7892 mL
60 mM 0.0263 mL 0.1315 mL 0.2631 mL 0.6577 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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6'-Sialyllactose Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6'-Sialyllactose35890-39-2BacterialVEGFRAktERKVascular endothelial growth factor receptorPKBProtein kinase BExtracellular signal regulated kinasessialylatedhuman milk oligosaccharidebifidobacteriagut microbiotanecrotizing enterocolitisInhibitorinhibitorinhibit

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