6'-Sialyllactose sodium

Name: 6'-Sialyllactose sodium
Brand: MedChemExpress
SKU: HY-137335
Rating: 4.5 (1 reviews)

Cat. No.: HY-137335 Purity: ≥98.0%: Data Sheet
COA

SDS
Handling Instructions
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6'-Sialyllactose sodium promotes the growth of beneficial bacteria (such as Bifidobacterium and lactobacillus) and inhibits the proliferation of harmful bacteria. 6'-Sialyllactose sodium exhibits anti-inflammatory and anti-angiogenic activities. 6'-Sialyllactose sodium promotes the muscle health.

For research use only. We do not sell to patients.

6'-Sialyllactose sodium Chemical Structure

CAS No. : 157574-76-0

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 6'-Sialyllactose sodium:

6'-Sialyllactose In-stock

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ERK ERK1 ERK2 ERK5 ERK8

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

6'-Sialyllactose sodium (0-50 μM, 24 h) inhibits Dihydrotestosterone-induced proliferation of HUVECs, suppresses tubular structure formation, inhibits the activation of VEGFR-2-related Akt-ERK signaling pathway^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[4]

Cell Line:	HUVEC
Concentration:	0-50 μM
Incubation Time:	24 h
Result:	Downregulated levels of p-Akt and p-ERK.

In Vivo

6'-Sialyllactose sodium (5% added to mouse diet, 2 weeks) alleviates the anxiety-like behavior of mice, regulates the flora composition in social disruption (SDR)-stressed mouse model^[2].
6'-Sialyllactose sodium (100 mg/kg, po, once daily, 5 times a week for 12 weeks) increases the muscle mass and strength, thereby improving the exercise endurance of mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	SDR-stressed mouse model^[2]
Dosage:	5% added to mouse diet
Administration:	po, 2 weeks
Result:	Reduced the anxiety-like behavior in open field tests. Maintained the number of DCX-positive cells in the hippocampus.

Animal Model:	C57BL/6J mouse models^[3]
Dosage:	100 mg/kg
Administration:	po, once daily, 5 times a week for 12 weeks
Result:	Increased the mouse running distance. Increased the absolute weight of gastrocnemius and soleus muscles.

Molecular Weight

655.53

Formula

C₂₃H₃₈NNaO₁₉

CAS No.

157574-76-0

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@](O[C@@]([C@@H]1NC(C)=O)([H])[C@H](O)[C@H](O)CO)(C[C@@H]1O)OC[C@H]([C@@H]([C@@H]2O)O)O[C@H]([C@@H]2O)O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (152.55 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5255 mL	7.6274 mL	15.2548 mL
5 mM	0.3051 mL	1.5255 mL	3.0510 mL
10 mM	0.1525 mL	0.7627 mL	1.5255 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 12.5 mg/mL (19.07 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (280 KB) SDS (393 KB)

COA (257 KB) HNMR (147 KB) MS (174 KB)

Handling Instructions (2659 KB)

References

[1]. MariarosariaMarotta, et al. The predominant milk oligosaccharide 6′-sialyllactose reduces the internalisation of Pseudomonas aeruginosa in human pneumocytes. Journal of Functional Foods Volume 6, January 2014, Pages 367-373.

[2]. Tarr AJ, et al., The prebiotics 3'Sialyllactose and 6'Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut-brain axis. Brain Behav Immun. 2015 Nov;50:166-177. [Content Brief]

[3]. Park EJ, et al., 6'-Sialyllactose Enhances Exercise Performance via Increased Muscle Mass and Strength. Nutrients. 2024 Aug 7;16(16):2600. [Content Brief]

[4]. Kim EY, et al., 6-sialyllactose ameliorates dihydrotestosterone-induced benign prostatic hyperplasia through suppressing VEGF-mediated angiogenesis. BMB Rep. 2019 Sep;52(9):560-565. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.5255 mL	7.6274 mL	15.2548 mL	38.1371 mL
	5 mM	0.3051 mL	1.5255 mL	3.0510 mL	7.6274 mL
	10 mM	0.1525 mL	0.7627 mL	1.5255 mL	3.8137 mL
	15 mM	0.1017 mL	0.5085 mL	1.0170 mL	2.5425 mL
	20 mM	0.0763 mL	0.3814 mL	0.7627 mL	1.9069 mL
	25 mM	0.0610 mL	0.3051 mL	0.6102 mL	1.5255 mL
	30 mM	0.0508 mL	0.2542 mL	0.5085 mL	1.2712 mL
	40 mM	0.0381 mL	0.1907 mL	0.3814 mL	0.9534 mL
	50 mM	0.0305 mL	0.1525 mL	0.3051 mL	0.7627 mL
	60 mM	0.0254 mL	0.1271 mL	0.2542 mL	0.6356 mL
	80 mM	0.0191 mL	0.0953 mL	0.1907 mL	0.4767 mL
	100 mM	0.0153 mL	0.0763 mL	0.1525 mL	0.3814 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.