1. GPCR/G Protein
  2. CRFR
  3. α-Helical CRF(9-41) TFA

α-Helical CRF(9-41) TFA is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) TFA is also a partial agonist of CRF1 receptor with an EC50 of 140 nM.

For research use only. We do not sell to patients.

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α-Helical CRF(9-41) TFA Chemical Structure

α-Helical CRF(9-41) TFA Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Description

α-Helical CRF(9-41) TFA is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) TFA is also a partial agonist of CRF1 receptor with an EC50 of 140 nM[1][2].

IC50 & Target

CRFR1

 

CRFR2

 

Molecular Weight

3940.42

Formula

C168H275F3N46O55S2

Appearance

Solid

Color

White to off-white

Sequence

Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2

Sequence Shortening

DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 1.82 mg/mL (0.46 mM; ultrasonic and adjust pH to 3 with HCl)

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Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
α-Helical CRF(9-41) TFA
Cat. No.:
HY-P1294A
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