2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. Ziv-aflibercept

Ziv-aflibercept is a soluble inhibitor of vascular endothelial growth factor (VEGF). Ziv-aflibercept is an adaptive variant of Aflibercept (HY-108801), Ziv-aflibercept has a low PH value and high osmotic pressure when compared to Aflibercept. Ziv-aflibercept has potential applications in metastatic colorectal carcinoma and retinal diseases.

For research use only. We do not sell to patients.

Ziv-aflibercept Chemical Structure

Ziv-aflibercept Chemical Structure

CAS No. : 1609655-49-3

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Ziv-aflibercept Related Antibodies

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Description

Ziv-aflibercept is a soluble inhibitor of vascular endothelial growth factor (VEGF). Ziv-aflibercept is an adaptive variant of Aflibercept (HY-108801), Ziv-aflibercept has a low PH value and high osmotic pressure when compared to Aflibercept. Ziv-aflibercept has potential applications in metastatic colorectal carcinoma and retinal diseases[1][2].

In Vitro

Ziv-aflibercept (0.25, 0.5, 1.0 and 5 mg/mL; 24 h) reduces mitochondrial membrane potential in ARPE-19 cells with dose dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ziv-aflibercept Related Antibodies

Cell Viability Assay[1]

Cell Line: ARPE-19 cells.
Concentration: 0.25, 0.5, 1.0 and 5 mg/mL.
Incubation Time: 24 h.
Result: Insignificantly affected cell viability (below 1 mg/mL).
In Vivo

Ziv-aflibercept (25 mg/mL; intravitreal injection; single dose) insignificantly causes cataract, retinal detachment and other related complications in the right eye of the rabbit[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

96.9 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ziv-aflibercept]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ziv-aflibercept Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ziv-aflibercept1609655-49-3VEGFRVascular endothelial growth factor receptorARPE-19 cellsRabbitInhibitorinhibitorinhibit

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