2. Cell Cycle/DNA Damage
  3. Checkpoint Kinase (Chk)
  4. VRX0466617

VRX0466617 is a selective and ATP-competitive Chk2 inhibitor with an IC50 of 120 nM and a Ki of 11 nM. VRX0466617 does not inhibit the related Chk1 activity. VRX0466617 can be used in the study of cancer.

For research use only. We do not sell to patients.

VRX0466617 Chemical Structure

VRX0466617 Chemical Structure

CAS No. : 926906-64-1

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Based on 1 publication(s) in Google Scholar

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Description

VRX0466617 is a selective and ATP-competitive Chk2 inhibitor with an IC50 of 120 nM and a Ki of 11 nM. VRX0466617 does not inhibit the related Chk1 activity. VRX0466617 can be used in the study of cancer.

IC50 & Target[1]

Chk1

120 nM (IC50)

Chk1

11 nM (Ki)

In Vitro

VRX0466617 (10-30 μM) inhibits both the autophosphorylation of Chk2 and the phosphorylation of Cdc25C substrate in vitro kinase reactions[1].
VRX0466617 (0.05-10 μM; 30-180 min) inhibits the phosphorylation of Chk2 Ser19 and Ser33-35, but not of Chk2 Thr68 in ionizing radiation (IR)-induced cells[1].
VRX0466617 induces the phosphorylation of Chk2 Thr68 in the absence of DNA damage[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VRX0466617 Related Antibodies

Cell Viability Assay[1]

Cell Line: LCL-N cells treated with ionizing radiation (IR).
Concentration: 0.05 μM, 0.5 μM, 5 μM, 10 μM
Incubation Time: 30 min, 180 min
Result: Markedly inhibited the phosphorylation of Ser33-35 and, to a less extent, of Ser19, but not of Thr68.
Molecular Weight

462.36

Formula

C19H20BrN5O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OCC(C)NC(C(C(NS1)=O)=C1NC2=CC=C(NC3=CC=C(Br)C=C3)C=C2)=N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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VRX0466617 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VRX0466617926906-64-1VRX 0466617VRX-0466617Checkpoint Kinase (Chk)cancerChk2 Ser19Chk2 Ser33-35Inhibitorinhibitorinhibit

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