2. Metabolic Enzyme/Protease Apoptosis
  3. Oxidative Phosphorylation Mitochondrial Metabolism Apoptosis
  4. TPP-IOA

TPP-IOA is a cytochrome c peroxidase inhibitor. TPP-IOA inhibits apoptosis by preventing cardiolipin oxidation and cytochrome c release to the cytosol. TPP-IOA disrupts oxidative phosphorylation in isolated mitochondria. TPP-IOA inhibits cell death in SH-SY5Y cells grown in glucose, but not galactose. TPP-IOA causes mitochondrial depolarization and network fragmentation. TPP-lOA mitigates radiation induced death in mice.

For research use only. We do not sell to patients.

TPP-IOA

TPP-IOA Chemical Structure

CAS No. : 1423018-61-4

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

TPP-IOA Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TPP-IOA is a cytochrome c peroxidase inhibitor. TPP-IOA inhibits apoptosis by preventing cardiolipin oxidation and cytochrome c release to the cytosol. TPP-IOA disrupts oxidative phosphorylation in isolated mitochondria. TPP-IOA inhibits cell death in SH-SY5Y cells grown in glucose, but not galactose. TPP-IOA causes mitochondrial depolarization and network fragmentation. TPP-lOA mitigates radiation induced death in mice[1].

In Vitro

TPP-IOA (0-10 μM) physically interacts with cytochrome c, dose-dependently inhibiting both ascorbate-mediated cytochrome c reduction and the rate of resorufin formation in cytochrome c/cardiolipin solution[1].
TPP-IOA (0.5-10 μM) suppresses resorufin formation in isolated mitochondria, with significant inhibition at 5 μM, which is due to its imidazole-containing oleic acid moiety[1].
TPP-IOA (0-10 μM) exhibits IC50 values of 0.65 nmol per nmol cytochrome c for peroxidase activity and 5.28 nmol per nmol cytochrome c for reduction activity[1].
TPP-IOA (0.5-10 μM) dose-dependently reduces the respiratory control ratio and oxidative phosphorylation coupling efficiency in rat liver mitochondria[1].
TPP-IOA (1 μM, 3 h) reduces mitochondrial membrane potential, disrupts mitochondrial reticulum morphology, decreases mitochondrial content, and inhibits FCCP-uncoupled respiration while maintaining basal oxygen consumption in SH-SY5Y cells[1].
TPP-IOA (0.25-5 μM) inhibits H2O2-induced total death & caspase-3 activity in SH-SY5Y cells in glucose but not galactose medium[1][2].
TPP-IOA (2.5-5 μM, 48 h) shows radiation mitigating effects on mouse embryonic cells in a model of intrinsic apoptosis induced in mouse embryonic cells by γirradiation as evidenced by PS externalization, caspase 3/7 activation and cyt c release[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TPP-IOA Related Antibodies

Immunofluorescence[1]

Cell Line: SH-SY5Y cells
Concentration: 1 μM
Incubation Time: 3 h
Result: Showed a less interconnected, more fragmented mitochondrial reticulum.
Increased the absolute number of individual mitochondrial network-like structures in cells.
In Vivo

TPP-IOA (5 mg/kg, i.p., daily, 52 days) demonstrates significant radiomitigative effects in female C57BL/6NTac mice following 9.25 Gy total body irradiation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6NTac female mice were exposed to total body irradiation to a dose of 9.25 Gy using a cesium source[2].
Dosage: 5 mg/kg
Administration: i.p. daily for 52 days (10 min, 1 h before irradiation or 10 min, 1 h, 5 h 24 h after irradiation)
Result: Showed a strong radiomitigative effect.
Molecular Weight

731.78

Formula

C42H56BrN2O2P
CAS No.
SMILES

CCCCCC[C@H](N1C=CN=C1)C/C=C\CCCCCCCC(OCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=O.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

TPP-IOA Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TPP-IOA1423018-61-4Oxidative PhosphorylationMitochondrial MetabolismApoptosisOxidative phosphorylationCytochrome cPeroxidaseTriphenylphosphoniumInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TPP-IOA
Cat. No.:
HY-176775
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.