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TK-112690 is a UPP1 inhibitor. TK-112690 inhibits murine small intestinal uridine phosphorylase (UPase) with an IC50 of 12.5 μM and human small intestinal UPase with an IC50 of 20.0 μM in vitro. TK-112690 increases plasma uridine concentration in mice. TK-112690 can be used for the study of cancer and pulmonary fibrosis.

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TK-112690

TK-112690 Chemical Structure

CAS No. : 22423-26-3

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Description

TK-112690 is a UPP1 inhibitor. TK-112690 inhibits murine small intestinal uridine phosphorylase (UPase) with an IC50 of 12.5 μM and human small intestinal UPase with an IC50 of 20.0 μM in vitro. TK-112690 increases plasma uridine concentration in mice. TK-112690 can be used for the study of cancer and pulmonary fibrosis[1][2][3].

In Vivo

TK-112690 (10-30 mg/kg, i.p., 3 h before and after methotrexate (HY-14519) on Days 2-3, 4 weeks) mitigates methotrexate (MTX) (HY-14519)-induced weight loss in LPS (HY-D1056)-treated C57BL/6 mice[2].
TK-112690 (60 mg/kg, i.p., 3 h before and after MTX on Days 2-4, 7 days) reduces MTX-induced mucosal permeability loss in C57BL/6 female mice[2].
TK-112690 (120 mg/kg, i.p., detected at 0.08-12 h post-dose) increases plasma uridine concentration in CD-1 female mice[2].
TK-112690 (667-3000 mg/kg/day, continuous s.c. infusion via osmotic pumps for 24-72 h) elevates plasma uridine (UR) concentration in a linear manner in BDF-1 mice[3].
TK-112690 (60 mg/kg, i.p., twice daily with 6-8 h interval on Days 7-20) reduces pulmonary fibrosis in C57BL/6 mice with Bleomycin (HY-108345)-induced fibrosis[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice[2]
Dosage: 10, 30 mg/kg
Administration: i.p., 3 h before and after methotrexate (HY-14519) on Days 2-3, 4 weeks
Result: Mitigated MTX-induced weight loss in LPS-treated C57BL/6 mice.
Animal Model: C57BL/6 mice[2]
Dosage: 120 mg/kg
Administration: i.p., detected at 0.08-12 h post-dose
Result: Reduced MTX-induced mucosal permeability loss in C57BL/6 female mice.
Animal Model: CD-1 female mice[2]
Dosage: 120 mg/kg
Administration: i.p., detected at 0.08-12 h post-dose
Result: Increased plasma uridine concentration in CD-1 female mice.
Animal Model: BDF-1 mice[3]
Dosage: 667, 833, 3000 mg/kg/day
Administration: s.c. infusion via osmotic pumps for 24-72 h
Result: Elevated plasma uridine (UR) concentration in a linear manner in BDF-1 mice.
Animal Model: C57BL/6 mice[3]
Dosage: 60 mg/kg
Administration: i.p., twice daily with 6-8 h interval on Days 7-20
Result: Reduced pulmonary fibrosis in C57BL/6 mice with Bleomycin (HY-108345)-induced fibrosis.
Molecular Weight

240.21

Formula

C10H12N2O5
CAS No.
SMILES

CC(C1=O)=CN(C2=N1)[C@@]3([H])[C@](O2)([H])[C@@](O)([H])[C@@](O3)([H])CO
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Please store the product under the recommended conditions in the Certificate of Analysis.
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TK-11269022423-26-3TK112690TK 112690OthersUPP1UPasecancerpulmonary fibrosisInhibitorinhibitorinhibit

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