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Results for "

whitening

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (1) Autophagy (1) Bacterial (2) Biochemical Assay Reagents (3) CDK (1) DNA/RNA Synthesis (1) Drug Derivative (1) Endogenous Metabolite (1) Fluorescent Dye (2) Glycosidase (1) GSK-3 (1) Heme Oxygenase (HO) (1) Interleukin Related (2) JAK (2) Melanocortin Receptor (1) MMP (1) NF-κB (2) p38 MAPK (1) Parasite (1) PKA (1) Prostaglandin Receptor (1) Reference Standards (3) STAT (2) Thymidylate Synthase (1) Tyrosinase (18) β-catenin (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Endocrinology (1) Infection (3) Inflammation/Immunology (8) Metabolic Disease (3)

By Targets:

Akt (1)

Apoptosis (1)

Autophagy (1)

Bacterial (2)

Biochemical Assay Reagents (3)

CDK (1)

DNA/RNA Synthesis (1)

Drug Derivative (1)

Endogenous Metabolite (1)

Fluorescent Dye (2)

Glycosidase (1)

GSK-3 (1)

Heme Oxygenase (HO) (1)

Interleukin Related (2)

JAK (2)

Melanocortin Receptor (1)

MMP (1)

NF-κB (2)

p38 MAPK (1)

Parasite (1)

PKA (1)

Prostaglandin Receptor (1)

Reference Standards (3)

STAT (2)

Thymidylate Synthase (1)

Tyrosinase (18)

β-catenin (1)

By Research Areas:

Cancer (6)

Cardiovascular Disease (1)

Endocrinology (1)

Infection (3)

Inflammation/Immunology (8)

Metabolic Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-143449

Tyrosinase-IN-2	Tyrosinase	Others
Tyrosinase-IN-2 (compound 67) is a potent inhibitor of tyrosinase. Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-2 has the potential for the research of skin whitening agents and food preservatives .

HY-N1780

3,4-Dimethoxyphenol	Tyrosinase Bacterial	Infection
3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound and can use as a whitening agent in cosmetics. 3,4-Dimethoxyphenol exhibits broad-spectrum antimicrobial activity. 3,4-Dimethoxyphenol has tyrosinase-inhibiting activity. 3,4-Dimethoxyphenol has potent antioxidant effect isolated from the bacterial fermentation broth. 3,4-Dimethoxyphenol can be used for the study of infection .

HY-N2278

Kushenol A 3 Publications Verification Leachianone E	Tyrosinase Glycosidase	Cancer
Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC₅₀ and K_ivalues of 1.1 μM and 0.4 μM, respectively . Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC₅₀: 45 μM; K_i: 6.8 μM) and β-amylase . Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging .

HY-N3091

Persiconin	Tyrosinase	Others
Persiconin is a tyrosinase Inhibitor. Persiconin can be isolated from Prunus persica. Persiconin has tyrosinase inhibitory activity of 46% at 500 μM. Persiconin can be used in whitening research .

HY-121322

Neoagarobiose	Others	Others
Neoagarobiose has both a moisturizing effect on skin and a whitening effect on melanoma cells. RagaA11 is an endo-type beta-agarase hydrolysing not only agarose, but also neoagarotetraose, to yield neoagarobiose as the final main product .

HY-143448

Tyrosinase-IN-1	Tyrosinase	Others
Tyrosinase-IN-1 (compound 90) is a potent inhibitor of tyrosinase. Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-1 has the potential for the research of skin whitening agents and food preservatives .

HY-143450

Tyrosinase-IN-3	Tyrosinase	Others
Tyrosinase-IN-3 (compound 54) is a potent inhibitor of tyrosinase. Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-3 has the potential for the research of skin whitening agents and food preservatives .

HY-143451

Tyrosinase-IN-4	Tyrosinase	Others
Tyrosinase-IN-4 (compound 34) is a potent inhibitor of tyrosinase. Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-4 has the potential for the research of skin whitening agents and food preservatives .

HY-N10337

Norjuziphine (-)-Norjuziphine	Drug Derivative	Cancer
Norjuziphine ((-)-Norjuziphine) is an alkaloid found in the lotus flower (Nelumbo nucifera). Norjuziphine inhibits the melanogenesis of murine B16 melanoma 4A5 cells stimulated by Theophylline (HY-B0809) (IC₅₀=14.4 μM). Norjuziphine is promising for research of skin whitening and related skin pigmentation diseases .

HY-N1780R

3,4-Dimethoxyphenol (Standard)	Reference Standards Tyrosinase Bacterial	Infection
3,4-Dimethoxyphenol (Standard) is the analytical standard of Lithocholic acid. This product is intended for research and analytical applications. 3,4-Dimethoxyphenol is a plant-derived phenylpropanoid compound and can use as a whitening agent in cosmetics. 3,4-Dimethoxyphenol exhibits broad-spectrum antimicrobial activity. 3,4-Dimethoxyphenol has tyrosinase-inhibiting activity. 3,4-Dimethoxyphenol has potent antioxidant effect isolated from the bacterial fermentation broth. 3,4-Dimethoxyphenol can be used for the study of infection .

HY-B1461

Deoxyarbutin	Tyrosinase Apoptosis	Cancer
Deoxyarbutin is an orally active tyrosinase inhibitor that can promote apoptosis of melanoma cells, enhance the vitality of mouse acinar cells, and has skin whitening and anti-tumor activity ^[1][2][3].

HY-169764

Pseudane V	Endogenous Metabolite	Others
Pseudane V is the secondary metabolite that can be isolated from the marine bacterium Pseudoalteromonas sp. M2. Pseudane V inhibits the melanin synthesis in cell Melan-A, and can be used as a potential skin whitening agent .

HY-W015782

4-Ethylresorcinol	Tyrosinase PKA	Metabolic Disease Inflammation/Immunology
4-Ethylresorcinol is a derivative of resorcinol and can serve as a substrate for tyrosinase. 4-Ethylresorcinol has anti-hyperpigmentation and antioxidant effects and can inhibit melanin synthesis. 4-Ethylresorcinol has potential whitening value .

HY-78700

4-Bromobenzoic acid	Tyrosinase	Metabolic Disease
4-Bromobenzoic acid is a tyrosinase inhibitor (IC₅₀ range 0-0.3 mg/mL). 4-Bromobenzoic acid can be metabolized through the protocatechuic acid (PCA) pathway. 4-Bromobenzoic acid can be used for research on cosmetic whitening or pigmentation conditions .

HY-W127738

6-O-Stearoyl-L-ascorbic acid Vitamin C stearate; Ascorbic acid 6-stearate; Ascorbyl stearate	Biochemical Assay Reagents	Others
6-O-Staroyl-L-ascorbic acid is an organic compound commonly used in cosmetics and skin care products. It can be used as an antioxidant and whitening agent, and is widely used in anti-aging, moisturizing and skin repairing. In addition, this compound is used as a catalyst or buffer in certain chemical reactions.

HY-W003607

3-O-Ethyl-L-ascorbic acid	Tyrosinase	Inflammation/Immunology
3-O-Ethyl-L-ascorbic acid is a stable derivative of vitamin C and a cosmetic tyrosinase inhibitor. 3-O-Ethyl-L-ascorbic acid has antioxidant, anti-aging, and skin-whitening activities. 3-O-Ethyl-L-ascorbic acid is often used in the study of cosmetic .

HY-W009938

Anthrone 1 Publications Verification Anthracen-9(10H)-one	Biochemical Assay Reagents	Others
Anthrone is an organic compound commonly used as a dye and intermediate. It can be used to make products such as pigments, dyes and fluorescent whitening agents, and is widely used in certain industrial production fields such as textile manufacturing, soap making and paper making. In addition, this compound is also used as a reagent and catalyst in some organic synthesis reactions.

HY-133680

β-Tocopherol	Tyrosinase	Others
β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol .

HY-126618

Aspochalasin I	Tyrosinase	Cancer
Aspochalasin I exhibits cytotoxicity against cancer cells NCIH460, MCF-7 and SF-268, with IC₅₀s of 22.1, 33.4 and 19.9 μM. Aspochalasin I inhibits melanogenesis (IC₅₀ of 22.4 μM) through inhibition of tyrosinase, and can thus be used as whitening agent .

HY-W003607R

3-O-Ethyl-L-ascorbic acid (Standard)	Reference Standards Tyrosinase	Inflammation/Immunology
3-O-Ethyl-L-ascorbic acid (Standard) is the analytical reference standard for 3-O-Ethyl-L-ascorbic acid. 3-O-Ethyl-L-ascorbic acid is a stable derivative of vitamin C and a cosmetic tyrosinase inhibitor. 3-O-Ethyl-L-ascorbic acid has antioxidant, anti-aging, and skin-whitening activities. 3-O-Ethyl-L-ascorbic acid is often used in the study of cosmetic .

HY-N6069

Raspberry ketone glucoside 1 Publications Verification	Interleukin Related JAK STAT	Inflammation/Immunology
Raspberry ketone glucoside is a melanogenesis inhibitor. Raspberry ketone glucoside inhibits melanogenesis by activating the IL6/JAK1/STAT3 pathway, inhibiting the transcriptional activity of MITFa, and its downstream expression levels of the TYR and TYRP1a genes. Raspberry ketone glucoside shows remarkable whitening activity on both B16F10 cells in vitro and zebrafish model in vivo .

HY-N6006

1,3,6-Tri-O-galloyl-beta-D-glucose 1,3,6-Tri-O-galloyl-β-D-glucose	Others	Others
1,3,6-Tri-O-galloyl-beta-D-glucose is a non-covalent inhibitor of tyrosinase (TYR), which can block the rate-limiting step of melanin synthesis and inhibit melanin deposition. 1,3,6-Tri-O-galloyl-beta-D-glucose has antioxidant and anti-inflammatory activities and can be used as a natural active ingredient to develop anti-freckle and whitening skin care products .

HY-W721119

7-Methylsulfinylheptyl isothiocyanate	p38 MAPK Autophagy	Inflammation/Immunology Cancer
7-Methylsulfinylheptyl isothiocyanate is an activator for MAPK signaling pathway, which downregulates the melanogenesis related proteins and suppresses the melanin synthesis in B16-F1 cells. 7-Methylsulfinylheptyl isothiocyanate induces autophagy. 7-Methylsulfinylheptyl isothiocyanate is an inducer for phase II enzyme, which exhibits chemoprotective effect against carcinogen. 7-Methylsulfinylheptyl isothiocyanate can be used as cosmetic ingredient for skin whitening and anti-inflammation .

HY-W750459

Fluorescent brightener 28 (Technical Grade)	Fluorescent Dye	Others
Fluorescent brightener 28 (Technical Grade) is a fluorescent whitening agent commonly used in the padding process of the textile industry. Fluorescent brightener 28 is capable of staining polysaccharides such as cellulose, and when the plasma membrane ruptures, it also weakly stains the cytoplasm and strongly stains the cell nucleus. Additionally, Fluorescent brightener 28 can be utilized to detect intracellular chitin in living cells. Fluorescent Brightener 28 also is a visible light emitting diode (LED)-light sensitive photoinitiator for free radical photopolymerizations .

HY-N1002

Cadin-1(14)-ene-7a,11-diol	Melanocortin Receptor	Metabolic Disease
Cadin-1(14)-ene-7a,11-diol is a sesquiterpene alcohol with melanogenesis inhibitory activity. Cadin-1(14)-ene-7a,11-diol inhibits the melanogenesis in B16 melanoma cells induced with α-MSH (HY-P0252). Cadin-1(14)-ene-7a,11-diol can be used as a potential skin-whitening agent .

HY-D0367

Fluorescent Brightener 28 Calcofluor White M2R	Fluorescent Dye	Others
Fluorescent brightener 28 is a fluorescent whitening agent commonly used in the padding process of the textile industry. Fluorescent brightener 28 is capable of staining polysaccharides such as cellulose, and when the plasma membrane ruptures, it also weakly stains the cytoplasm and strongly stains the cell nucleus. Additionally, Fluorescent brightener 28 can be utilized to detect intracellular chitin in living cells. Fluorescent Brightener 28 also is a visible light emitting diode (LED)-light sensitive photoinitiator for free radical photopolymerizations .

HY-P5250

Palmitoyl tripeptide-5	MMP	Others
Palmitoyl tripeptide-5 is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

HY-N6069R

Raspberry ketone glucoside (Standard)	Interleukin Related JAK STAT	Inflammation/Immunology
Raspberry ketone glucoside (Standard) is the analytical standard of Raspberry ketone glucoside (HY-N6069). Raspberry ketone glucoside is a melanogenesis inhibitor. Raspberry ketone glucoside inhibits melanogenesis by activating the IL6/JAK1/STAT3 pathway, inhibiting the transcriptional activity of MITFa, and its downstream expression levels of the TYR and TYRP1a genes. Raspberry ketone glucoside shows remarkable whitening activity on both B16F10 cells in vitro and zebrafish model in vivo .

HY-W013812

Ethyl linoleate Linoleic Acid ethyl ester; Mandenol	Tyrosinase Akt GSK-3 β-catenin Biochemical Assay Reagents NF-κB Heme Oxygenase (HO)	Cardiovascular Disease Inflammation/Immunology
Ethyl linoleate (Linoleic Acid ethyl ester) is an orally active unsaturated fatty acid. Ethyl linoleate inhibits the Akt/GSK3β/β-catenin signaling pathway and the activation of NF-κB. Ethyl linoleate induces heme oxygenase-1 and inhibits tyrosinase. Ethyl linoleate has whitening and anti-inflammatory effects. Ethyl linoleate promotes compound absorption. Ethyl linoleate has a significant influence on atherosclerosis. Ethyl linoleate is used in the research of inflammatory diseases. Ethyl linoleate can be used in cosmetics

HY-133079

Ascorbyl tetra-2-hexyldecanoate tetra-isopalmitoyl Ascorbic acid; IPAA; Tetrahexyldecyl Ascorbate	Prostaglandin Receptor	Endocrinology
Ascorbyl tetra-2-hexyldecanoate (tetra-isopalmitoyl Ascorbic acid; IPAA) is a lipophilic derivative of vitamin C (L-ascorbic acid). Ascorbyl tetra-2-hexyldecanoate (100 μM ) can prevent the decrease in viability of HaCaT keratinocytes induced by UVB, hydrogen peroxide, or tert-butyl hydroperoxide, and reduce the production of IL-1α and prostaglandin E2 (PGE2). Topical application of ascorbyl tetra-2-hexyldecanoate (1%) increases epidermal viability thickness, stratum corneum water content, and skin smoothness, and reduces skin roughness in hairless mice. Ascorbyl tetra-2-hexyldecanoate can be used to develop skin whitening agents in the beauty industry.

HY-W050154R

Kojic acid (Standard)	Reference Standards Parasite Tyrosinase NF-κB CDK	Infection Inflammation/Immunology Cancer
Kojic acid (Standard) is the analytical standard of Kojic acid. This product is intended for research and analytical applications. Kojic acid is a substance produced by Aspergillus oryzae, with various biological activities including antitumor, insecticidal, antibacterial, antioxidant, and radioprotective effects. Kojic acid exhibits tyrosinase inhibition activity by capturing copper ions that bind to the active site of tyrosinase, preventing its activation. Tyrosinase is a key enzyme in the biosynthesis of melanin, so kojic acid can block melanin production. Additionally, kojic acid shows potential inhibition of NF-κB activity in human keratinocytes, which may also be related to the anti-melanogenic effect induced by kojic acid. Kojic acid is effective when administered orally and can also be absorbed transdermally. Nano-carrier systems prepared with kojic acid demonstrate effective delivery of anticancer drugs. Kojic acid holds promise for research in cancer, infectious diseases, and skin whitening among other fields .

HY-W129441

N-Acetyl-4-S-cysteaminylphenol N-Ac-4-S-CAP	DNA/RNA Synthesis Tyrosinase Thymidylate Synthase	Others
N-Acetyl-4-S-mercaptoaminophenol (N-Ac-4-S-CAP) is a compound that is selectively cytotoxic to melanocytes of black mouse hair follicles. It can cause 98% depigmentation of black mouse hair follicles. N-Ac-4-S-CAP can produce visible changes in hair follicle melanocytes 4 hours after intraperitoneal injection, including aggregation of melanin granules and nuclear condensation. Electron microscopy observations showed that it caused progressive destruction of melanocytes, including swelling of membranous organelles, nuclear condensation, and cytoplasmic vacuolation, ultimately leading to complete cell necrosis. N-Ac-4-S-CAP has a specific cytotoxic effect on melanocytes that actively produce eumelanin, but may not affect precursor or dormant melanocytes. These properties suggest that N-Ac-4-S-CAP may have potential application value in the treatment of melanoma or skin whitening.

Cat. No.	Product Name	Type

HY-D0367

Fluorescent Brightener 28 Calcofluor White M2R	Fluorescent Dyes/Probes
Fluorescent brightener 28 is a fluorescent whitening agent commonly used in the padding process of the textile industry. Fluorescent brightener 28 is capable of staining polysaccharides such as cellulose, and when the plasma membrane ruptures, it also weakly stains the cytoplasm and strongly stains the cell nucleus. Additionally, Fluorescent brightener 28 can be utilized to detect intracellular chitin in living cells. Fluorescent Brightener 28 also is a visible light emitting diode (LED)-light sensitive photoinitiator for free radical photopolymerizations .

Fluorescent Brightener 28

Calcofluor White M2R

Fluorescent Dyes/Probes

Fluorescent brightener 28 is a fluorescent whitening agent commonly used in the padding process of the textile industry. Fluorescent brightener 28 is capable of staining polysaccharides such as cellulose, and when the plasma membrane ruptures, it also weakly stains the cytoplasm and strongly stains the cell nucleus. Additionally, Fluorescent brightener 28 can be utilized to detect intracellular chitin in living cells. Fluorescent Brightener 28 also is a visible light emitting diode (LED)-light sensitive photoinitiator for free radical photopolymerizations .

Cat. No.	Product Name	Type