Search Result

Results for "

uncoupler

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) AMPK (1) Anion Exchangers (1) Antibiotic (7) Apoptosis (10) ATP Synthase (1) Autophagy (8) Bacterial (20) Biochemical Assay Reagents (1) Calcium Channel (1) Cytochrome P450 (1) Endogenous Metabolite (6) Fungal (10) Gap Junction Protein (3) HIV (1) HSP (1) IFNAR (2) iGluR (2) Influenza Virus (1) Interleukin Related (1) Isotope-Labeled Compounds (8) Mitochondrial Metabolism (24) Mitophagy (1) mTOR (1) NO Synthase (3) Orthopoxvirus (1) Oxidative Phosphorylation (21) P-glycoprotein (1) p38 MAPK (3) Parasite (5) PINK1/Parkin (4) PKC (1) Potassium Channel (1) RABV (1) Raf (2) Reactive Oxygen Species (2) Reference Standards (3) SOD (1) STING (2) Transferrin Receptor (1) URAT1 (1)
By Research Areas:	Cancer (17) Cardiovascular Disease (3) Infection (22) Inflammation/Immunology (8) Metabolic Disease (20) Neurological Disease (7)

By Targets:

11β-HSD (1)

AMPK (1)

Anion Exchangers (1)

Antibiotic (7)

Apoptosis (10)

ATP Synthase (1)

Autophagy (8)

Bacterial (20)

Biochemical Assay Reagents (1)

Calcium Channel (1)

Cytochrome P450 (1)

Endogenous Metabolite (6)

Fungal (10)

Gap Junction Protein (3)

HIV (1)

HSP (1)

IFNAR (2)

iGluR (2)

Influenza Virus (1)

Interleukin Related (1)

Isotope-Labeled Compounds (8)

Mitochondrial Metabolism (24)

Mitophagy (1)

mTOR (1)

NO Synthase (3)

Orthopoxvirus (1)

Oxidative Phosphorylation (21)

P-glycoprotein (1)

p38 MAPK (3)

Parasite (5)

PINK1/Parkin (4)

PKC (1)

Potassium Channel (1)

RABV (1)

Raf (2)

Reactive Oxygen Species (2)

Reference Standards (3)

SOD (1)

STING (2)

Transferrin Receptor (1)

URAT1 (1)

By Research Areas:

Cancer (17)

Cardiovascular Disease (3)

Infection (22)

Inflammation/Immunology (8)

Metabolic Disease (20)

Neurological Disease (7)

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113371

2-Methylcitric acid Methylcitric acid	Endogenous Metabolite	Metabolic Disease
2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate .

HY-B1729

Phenoxyethanol	Oxidative Phosphorylation Bacterial Fungal	Infection
Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al .

HY-129051

Amoscanate CGP4540	Parasite Oxidative Phosphorylation	Others
Amoscanate (cgp4540) is phenyl isothiocyanate in which the hydrogen at the para-position has been replaced by a 4-nitroanilinyl group. Amoscanate is an anti-schistosomal agent. Amoscanate, as an isothiocyanate compound and uncoupler of oxidative phosphorylation, potently injures rodent ependyma .

HY-110284

BAM 15 5+ Cited Publications	Oxidative Phosphorylation Mitochondrial Metabolism	Others
BAM 15 is a mitochondrial protonophore uncoupler. BAM 15 is an oxidative phosphorylation (OXPHOS) uncoupler .

HY-162302

NMY1009	Others	Metabolic Disease
NMY1009 is a lipophilic C8-hydrocarbon chain conjugated analog that links mitochondrial uncouplers via ether linkages. NMY1009 can be released and enter the mitochondrial matrix and intermembrane space, thereby targeting mitochondrial uncoupler to adipose tissue and increasing energy expenditure in brown and white adipose tissue .

HY-176148

ZGL-18	Mitochondrial Metabolism	Metabolic Disease
ZGL-18 is an uncoupling protein 1 (UCP1)-inspired mitochondrial uncoupler. ZGL-18 activates brown adipocytes and reduces mitochondrial membrane potential .

HY-168639

AMPK activator 15	Mitochondrial Metabolism AMPK	Metabolic Disease
AP39 prodrug 1 (Compound M1) is a mitochondria-targeted H2S prodrug. AP39 prodrug 1 induces ROS-dependent mild mitochondrial uncoupling, activating mitochondria-associated AMPK to suppress Palmitic acid (PA) (HY-N0830)-induced lipid deposition in hepatocytes .

HY-117843

Ppc-1	Mitochondrial Metabolism Interleukin Related Bacterial	Infection Metabolic Disease Inflammation/Immunology
Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen *Porphyromonas gingivalis*. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities .

HY-153812

AST 7062601 AST070	Anion Exchangers	Metabolic Disease
AST 7062601 (AST070) is a Ucp1 inducer that strongly induces endogenous Ucp1 expression in primary mouse brown adipocytes. Ucp1 refers to uncoupling protein, found in brown and beige fat cells. In mammals, UCP1 oxidizes fatty acids and uncouples ATP production in mitochondria to promote energy dissipation as heat. AST 7062601 can be used to study thermogenic, uncoupled respiration .

HY-169926

AK-4	Mitochondrial Metabolism	Cancer
AK-4 is a glucose-lowering agent, acting function as a mitochondrial uncoupler .

HY-17598

Rafoxanide 5 Publications Verification	Oxidative Phosphorylation Parasite p38 MAPK Raf Apoptosis	Infection Cancer
Rafoxanide is a poent, orally active halogenated salicylaniline agent with antiparasitic activity. Rafoxanide interferes with energy metabolism in trematodes by uncoupling oxidative phosphorylation. Rafoxanide is also found to be a potent inhibitor of the BRAF V600E mutant protein, which is important in colorectal cancer. Rafoxanide can be used for the control of infestation with Hemonchus species or Fasciola species in sheep and cattle as well as Oestrus ovis in sheep. Rafoxanide can also be used for cancer research .

HY-100941

CCCP Maximum Cited Publications 109 Publications Verification Carbonyl cyanide 3-chlorophenylhydrazone; Carbonyl Cyanide m-Chlorophenylhydrazone	Oxidative Phosphorylation PINK1/Parkin STING IFNAR Mitochondrial Metabolism Bacterial Apoptosis	Inflammation/Immunology Cancer
CCCP is an oxidative phosphorylation (OXPHOS) uncoupler. CCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation .

HY-106472

Tioxaprofen EMD 26644	Bacterial	Infection
Tioxaprofen is a new anti-mycotic drug against Trichophyton mentagrophytes and T. rubrum, and is a potent uncoupling agent of mitochondrial respiration .

HY-121292

Clidanac	Oxidative Phosphorylation Mitochondrial Metabolism	Infection
Clidanac is a potent anti-inflammatory agent. Clidanac can uncouple the oxidative phosphorylation and can be used for the research of rheumatoid arthritis .

HY-100410

FCCP 60+ Cited Publications Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone	Oxidative Phosphorylation PINK1/Parkin Mitochondrial Metabolism	Cancer
FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation .

HY-136855

MitoPBN	Endogenous Metabolite	Metabolic Disease
MitoPBN is a mitochondria-targeted antioxidant. It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP. MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC₅₀=~77 μM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria.

HY-137922

SHS4121705	Mitochondrial Metabolism	Metabolic Disease
SHS4121705 is an orally effective mitochondrial uncoupling agent with an IC₅₀ of 4.3 μM in L6 myoblasts. SHS4121705 can be used in the study of non-alcoholic steatohepatitis (NASH) .

HY-W032022

1-Hexanol	Biochemical Assay Reagents Mitochondrial Metabolism	Others
1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties . 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism .

HY-158421

MS-L6	Oxidative Phosphorylation Mitochondrial Metabolism	Cancer
MS-L6 is a potent inhibitor of oxidative phosphorylation (OXPHOS) that can acts as electron transport chain complexes I (ETC-I) combining inhibition of NADH oxidation and uncoupling effect .

HY-N10094

Maculosidine	Others	Others
Maculosidine is a furoquinoline alkaloid that can be isolated from Balfourodendron riedelianum. Maculosidine inhibits ATP synthesis, basal, phosphorylating and uncoupled electron transport in plants. Maculosidine inhibits Hill reaction on spinach chloroplasts .

HY-148973

ZW290	ATP Synthase	Metabolic Disease
ZW290 is a compound to activate brown adipose tissue (BAT) thermogenic function. ZW290 increases the expression of uncoupling Protein 1 (UCP1) protein and inhibits ATP synthesis in BAT .

HY-17594

Oxyclozanide 2 Publications Verification	Oxidative Phosphorylation Parasite Bacterial Fungal	Infection
Oxyclozanide is an orally active salicylanilide anthelmintic agent that mainly acts by uncoupling oxidative phosphorylation in flukes. Oxyclozanide shows good anti-adenovirus, anti-biofilm, antifungal, and antibacterial activity .

HY-100941R

CCCP (Standard) Carbonyl cyanide 3-chlorophenylhydrazone (Standard); Carbonyl Cyanide m-Chlorophenylhydrazone (Standard)	Oxidative Phosphorylation PINK1/Parkin Reference Standards STING IFNAR Mitochondrial Metabolism Bacterial Apoptosis	Inflammation/Immunology Cancer
CCCP (Standard) is the analytical standard of CCCP. This product is intended for research and analytical applications. CCCP is an oxidative phosphorylation (OXPHOS) uncoupler. CCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation .

HY-100410R

FCCP (Standard) Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (Standard)	Oxidative Phosphorylation PINK1/Parkin Reference Standards Mitochondrial Metabolism	Cancer
FCCP (Standard) is the analytical standard of FCCP. This product is intended for research and analytical applications. FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation .

HY-P5315

eNOS pT495 decoy peptide	NO Synthase	Others
eNOS pT495 decoy peptide is a specific decoy peptide to prevent T495 phosphorylation reduced eNOS uncoupling and mitochondrial redistribution. eNOS pT495 decoy peptide is used in ventilator-induced lung injury research .

HY-159881

SHS206	Mitophagy	Metabolic Disease
SHS206 (compound 6n) is an orally active mitochondrial uncoupler that reduces hepatic triglyceride levels. SHS206 exhibits in vivo efficacy in the GAN mouse model and shows inhibitory effects on metabolic dysfunction-associated steatohepatitis (MASH) .

HY-B1729S1

Phenoxyethanol-d4	Isotope-Labeled Compounds Oxidative Phosphorylation Bacterial Fungal	Infection
Phenoxyethanol-d₄ is the deuterium labeled Phenoxyethanol. Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al .

HY-B1729S

Phenoxyethanol-d2	Isotope-Labeled Compounds Oxidative Phosphorylation Bacterial Fungal	Infection
Phenoxyethanol-d₂ is the deuterium labeled Phenoxyethanol . Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al .

HY-113371R

2-Methylcitric acid (Standard)	Endogenous Metabolite	Metabolic Disease
Omeprazole (sodium) (Standard) is the analytical standard of Omeprazole (sodium). This product is intended for research and analytical applications. Omeprazole sodium (H 16868 sodium), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole sodium shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM . Omeprazole sodium also inhibits growth of Gram-positive and Gram-negative bacteria . Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) .

HY-N9608

6-Ketocholestanol 3β-Hydroxy-5α-cholestan-6-one	Cytochrome P450	Others
6-Ketocholestanol is a recoupler for mitochondria, chromatophores and cytochrome oxidase proteoliposomes. 6-Ketocholestanol increases the membrane dipole potential .

HY-14881

Bedaquiline 35+ Cited Publications TMC207; R207910	Bacterial Antibiotic	Infection
Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-17594R

Oxyclozanide (Standard)	Oxidative Phosphorylation Parasite Bacterial Fungal	Infection
Oxyclozanide (Standard) is the analytical standard of Oxyclozanide. This product is intended for research and analytical applications. Oxyclozanide is an orally active salicylanilide anthelmintic agent that mainly acts by uncoupling oxidative phosphorylation in flukes. Oxyclozanide shows good anti-adenovirus, anti-biofilm, antifungal, and antibacterial activity .

HY-W032022S

1-Hexanol-d13	Isotope-Labeled Compounds Mitochondrial Metabolism	Others
1-Hexanol-d₁₃ is the deuterium labeled 1-Hexanol . 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties . 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism .

HY-W032022S3

1-Hexanol-d5	Mitochondrial Metabolism	Others
1-Hexanol-d₅ is the deuterium labeled 1-Hexanol . 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties . 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism .

HY-W032022S1

1-Hexanol-d11	Isotope-Labeled Compounds Mitochondrial Metabolism	Others
1-Hexanol-d₁₁ is the deuterium labeled 1-Hexanol . 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties . 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism .

HY-B1729R

Phenoxyethanol (Standard)	Oxidative Phosphorylation Reference Standards Bacterial Fungal	Infection
Phenoxyethanol (Standard) is the analytical standard of Phenoxyethanol. This product is intended for research and analytical applications. Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al .

HY-W032022S2

1-Hexanol-d3	Isotope-Labeled Compounds Mitochondrial Metabolism	Others
1-Hexanol-d₃ is the deuterium labeled 1-Hexanol . 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties . 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism .

HY-164803

CBD3063	Calcium Channel	Inflammation/Immunology
CBD3063 is a selective modulator of collapsin response mediator protein 2 (CRMP2). CBD3063 uncouples Cav2.2 from CRMP2. CBD3063 reverses neuropathic and inflammatory pain by reducing membrane expression of CaV2.2 .

HY-113371A

2-Methylcitric acid trisodium Methylcitric acid trisodium	Endogenous Metabolite	Metabolic Disease
2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate .

HY-153813

Z16078526	p38 MAPK Mitochondrial Metabolism	Others
Z16078526 induces endogenous Ucp1 expression, promotes p38 MAPK phosphorylation and lipolysis in primary mouse brown adipocytes. Z16078526 activates thermogenic gene expression and mitochondrial activity (uncoupled respiration) in mouse brown adipocytes. Z16078526 also stimulates thermogenesis in the mouse .

HY-134769

OPC-163493	Mitochondrial Metabolism Reactive Oxygen Species	Cardiovascular Disease Metabolic Disease
OPC-163493 is an orally active and liver-targeted mitochondrial uncoupling agent. OPC-163493 reduces the production of mitochondrial Δψ and ROS. OPC-163493 has anti-diabetic and lipid-lowering effects. In addition, OPC-163493 has a protective effect on cardiovascular disease .

HY-14881B

(Rac)-Bedaquiline (Rac)-TMC207; (Rac)-R207910	Bacterial	Infection
(Rac)-Bedaquiline is the racemate of Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting both the c- and the ε-subunit. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-W032022R

1-Hexanol (Standard)	Mitochondrial Metabolism	Others
1-Hexanol (Standard) is the analytical standard of 1-Hexanol. This product is intended for research and analytical applications. 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties . 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism .

HY-W032022S4

1-Hexanol-d2	Isotope-Labeled Compounds Mitochondrial Metabolism	Others
1-Hexanol-d₂ is deuterated labeled 1-Hexanol (HY-W032022). 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties . 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism .

HY-157933

SF-C5-TPP	Mitochondrial Metabolism	Infection
SF-C5-TPP is an potent mitochondria-targeted protonophoric uncoupler. SF-C5-TPP has significant proton transfer activity on model planar bilayer lipid membranes. SF-C5-TPP inhibits the growth of Bacillus subtilis with a MIC of 2 μM ^>[1].

HY-W011711

Benzarone Fragivix	URAT1 Oxidative Phosphorylation Apoptosis	Metabolic Disease
Benzarone (Fragivix) is an oral inhibitor of human urate transporter 1 (hURAT1) with an IC₅₀ value of 2.8 μM, and it also acts as an uncoupler of oxidative phosphorylation. Benzarone can cause liver damage and promote cell apoptosis and necrosis. Benzarone can be used to lower serum uric acid levels and for research in vascular diseases .

HY-17389

Genipin 10+ Cited Publications (+)-Genipin	Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research .

HY-113371S

2-Methylcitric acid-d3 Methylcitric acid-d₃	Endogenous Metabolite	Metabolic Disease
2-Methylcitric acid-d₃ is the deuterium labeled 2-Methylcitric acid. 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate .

HY-170369

SHO1122147	Mitochondrial Metabolism	Metabolic Disease
SHO1122147 (Compound 7m) affects the mitochondrial electron transport chain, exhibits mitochondrial uncoupling activity (EC₅₀=3.6 μM), and increases the oxygen consumption rate (OCR=69%) and promotes cellular respiration. SHO1122147 is orally active, and can be used in reaearch of obesity and metabolic dysfunction-associated steatohepatitis (MASH) .

HY-N7133

Diphenylamine hydrochloride N-Phenylaniline hydrochloride	Fungal Bacterial	Metabolic Disease
Diphenylamine hydrochloride (N-Phenylaniline hydrochloride) is an antihyperglycemic agent with oral activity and a common structure in non-steroidal anti-inflammatory drugs (NSAIDs) that uncouples oxidative phosphorylation in mitochondria, leading to a decrease in hepatic cell ATP levels and causing liver cell damage. Diphenylamine hydrochloride is also an industrial antioxidant, a dyeing mordant, and is used in agriculture as an antifungal and antibacterial agent .

Cat. No.	Product Name

HY-L046

Anti-Cardiovascular Disease Compound Library

1,913 compounds

Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels which include coronary heart disease, cerebrovascular disease, peripheral arterial disease, rheumatic heart disease, etc. CVDs are the number 1 cause of death globally. Smoking, unhealthy nutrition, aging population, lack of physical activity, arterial hypertension, or diabetes can promote cardiovascular disease like myocardial infarction or stroke. It is multifactorial and encompasses a multitude of mechanisms, such as eNOS uncoupling, reactive oxygen species formation, chronic inflammatory disorders and abnormal calcium homeostasis. Antioxidant, anti-inflammatory and anti-diabetes agents may reduce the cardiovascular disease risk.

MCE supplies a unique collection of 1,913 compounds with confirmed anti-cardiovascular activity. These compounds mainly target metabolic enzyme, membrane transporter, ion channel, inflammation related signaling pathways. MCE Anti-Cardiovascular Disease Compound Library can be used for cardiovascular diseases related research and high throughput and high content screening for new drugs.

HY-L089

Mitochondria-Targeted Compound Library

1,274 compounds

Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca²⁺ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation.

MCE supplies a unique collection of 1,274 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

Cat. No.	Product Name	Target	Research Area

HY-P2307

Tat-NR2Baa	iGluR NO Synthase	Neurological Disease
Tat-NR2BAA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95 .

HY-P5315

eNOS pT495 decoy peptide	NO Synthase	Others
eNOS pT495 decoy peptide is a specific decoy peptide to prevent T495 phosphorylation reduced eNOS uncoupling and mitochondrial redistribution. eNOS pT495 decoy peptide is used in ventilator-induced lung injury research .

HY-P2307A

Tat-NR2Baa TFA	iGluR NO Synthase	Neurological Disease
Tat-NR2BAA TFA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA TFA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95 .

Cat. No.	Product Name	Target	Research Area

HY-P991047

Anti-CD71/TfR1 Antibody JR-141 antibody (uncoupled from iduronate 2-sulfatase)	Transferrin Receptor	Neurological Disease Cancer
Anti-CD71/TfR1 Antibody (JR-141 antibody (uncoupled from iduronate 2-sulfatase)) is a humanized anti-human transferrin receptor (CD71; TfR) antibody. Anti-CD71/TfR1 Antibody is the antibody part of the fusion protein Pabinafusp alfa (HY-P99797). The recommend isotype control of Anti-CD71/TfR1 Antibody: Human IgG1 kappa, Isotype Control (HY-P99001) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113371

2-Methylcitric acid Methylcitric acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate .

HY-B1729

Phenoxyethanol	Microorganisms Source classification	Oxidative Phosphorylation Bacterial Fungal
Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al .

HY-W032022

1-Hexanol	Structural Classification Natural Products Microorganisms Animals Classification of Application Fields Source classification Other Diseases Disease Research Fields	Biochemical Assay Reagents Mitochondrial Metabolism
1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties . 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism .

HY-N9608

6-Ketocholestanol 3β-Hydroxy-5α-cholestan-6-one	Apocynaceae Diospyros virginiana L. Source classification Plants Steroids	Cytochrome P450
6-Ketocholestanol is a recoupler for mitochondria, chromatophores and cytochrome oxidase proteoliposomes. 6-Ketocholestanol increases the membrane dipole potential .

HY-B1729R

Phenoxyethanol (Standard)	Microorganisms Source classification	Oxidative Phosphorylation Reference Standards Bacterial Fungal
Phenoxyethanol (Standard) is the analytical standard of Phenoxyethanol. This product is intended for research and analytical applications. Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al .

HY-113371A

2-Methylcitric acid trisodium Methylcitric acid trisodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate .

HY-17389

Genipin Maximum Cited Publications 15 Publications Verification (+)-Genipin	Structural Classification Neurological Disease Classification of Application Fields Source classification Metabolic Disease Plants Endogenous metabolite Human Gut Microbiota Metabolites Iridoids Terpenoids Rubiaceae Gardenia jasminoides Ellis Inflammation/Immunology Disease Research Fields	Autophagy
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research .

HY-N10094

Maculosidine	Structural Classification Alkaloids Source classification Rutaceae Quinoline Alkaloids Plants Balfourodendron riedelianum (Engl.) Engl.	Others
Maculosidine is a furoquinoline alkaloid that can be isolated from Balfourodendron riedelianum. Maculosidine inhibits ATP synthesis, basal, phosphorylating and uncoupled electron transport in plants. Maculosidine inhibits Hill reaction on spinach chloroplasts .

HY-113371R

2-Methylcitric acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Endogenous metabolite	Endogenous Metabolite
Omeprazole (sodium) (Standard) is the analytical standard of Omeprazole (sodium). This product is intended for research and analytical applications. Omeprazole sodium (H 16868 sodium), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole sodium shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM . Omeprazole sodium also inhibits growth of Gram-positive and Gram-negative bacteria . Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor) .

HY-W032022R

1-Hexanol (Standard)	Structural Classification Natural Products Microorganisms Animals Source classification	Mitochondrial Metabolism
1-Hexanol (Standard) is the analytical standard of 1-Hexanol. This product is intended for research and analytical applications. 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties . 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism .

HY-N7133

Diphenylamine hydrochloride N-Phenylaniline hydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Amberboa moschata (L.) DC. Umbelliferae Plants Disease Research Fields	Fungal Bacterial
Diphenylamine hydrochloride (N-Phenylaniline hydrochloride) is an antihyperglycemic agent with oral activity and a common structure in non-steroidal anti-inflammatory drugs (NSAIDs) that uncouples oxidative phosphorylation in mitochondria, leading to a decrease in hepatic cell ATP levels and causing liver cell damage. Diphenylamine hydrochloride is also an industrial antioxidant, a dyeing mordant, and is used in agriculture as an antifungal and antibacterial agent .

HY-N6790

Nonactin Ammonium ionophore I	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields	Oxidative Phosphorylation Potassium Channel Mitochondrial Metabolism Bacterial Influenza Virus Apoptosis Antibiotic HSP
Nonactin is a macrotetrolide antibiotic and mitochondrial uncoupler with antibacterial, insecticidal, and acaricidal activities. Nonactin acts as an ionophore for monovalent cations, including K ⁺, and NH₄ ⁺, and it can also inhibit the surface expression of endogenous HSP60. In addition, Nonactin can induce apoptosis in β-catenin mutant tumor cells and has anti-tumor activity .

HY-N6687

Calcimycin 5+ Cited Publications A-23187; Antibiotic A-23187	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Polyether Antibiotics	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis .

HY-17389R

Genipin (Standard)	Structural Classification Human Gut Microbiota Metabolites Iridoids Terpenoids Source classification Rubiaceae Plants Gardenia jasminoides Ellis Endogenous metabolite	Autophagy
Genipin (Standard) is the analytical standard of Genipin. This product is intended for research and analytical applications. Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research .

HY-N6687A

Calcimycin hemicalcium salt A-23187 hemicalcium salt; Antibiotic A-23187 hemicalcium salt	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Polyether Antibiotics	Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic
Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca ²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis .

HY-18980

Rottlerin 10+ Cited Publications Mallotoxin; NSC 56346; NSC 94525	Structural Classification Chalcones Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Euphorbiaceae Plants Disease Research Fields Mallotus philippensis Cancer	PKC Autophagy Apoptosis HIV RABV
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC₅₀ values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation . Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection .

HY-W012722

4-Methyl-2-oxopentanoic acid 1 Publications Verification α-Ketoisocaproic acid	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite	Endogenous Metabolite Autophagy mTOR SOD
4-Methyl-2-oxopentanoic acid (α-Ketoisocaproic acid) is a metabolite of L-leucine and is involved in energy metabolism. 4-Methyl-2-oxopentanoic acid increases endoplasmic reticulum stress, promotes lipid accumulation in preadipocytes and insulin resistance by impairing mTOR and autophagy signaling pathways. 4-Methyl-2-oxopentanoic acid also causes oxidative damage, leading to cognitive deficits, inhibits α-ketoglutarate dehydrogenase activity, acts as an oxidative phosphorylation uncoupler and metabolic inhibitor. 4-Methyl-2-oxopentanoic acid acts as a nutrient signal and stimulates skeletal muscle protein synthesis. 4-Methyl-2-oxopentanoic acid can be used in the study of maple syrup urine disease .

Cat. No.	Product Name	Chemical Structure

HY-W032022S1

1-Hexanol-d11
1-Hexanol-d₁₁ is the deuterium labeled 1-Hexanol . 1-Hexanol, a primary alcohol, is a surfactant that can be employed in industrial processes to enhance interfacial properties . 1-Hexanol uncouples mitochondrial respiration by a non-protonophoric mechanism .

HY-113371S

2-Methylcitric acid-d3

2-Methylcitric acid-d₃ is the deuterium labeled 2-Methylcitric acid. 2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate .

HY-14881S1

(Rac)-Bedaquiline-d6
(Rac)-Bedaquiline-d₆ is the deuterium labeled Bedaquiline (HY-14881) . Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .